Research Article

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12/04/2013
Congenital heart defects; Gene polymorphism; Meta-analysis; Methylenetetrahydrofolate reductase

Numerous studies have evaluated the association between the maternal C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene and congenital heart defect (CHD) risk in the Chinese Han population. However, the specific association is still controversial. Six separate studies with 1089 subjects in the Chinese Han population on the relationship between the C677T ... more

K.H. Chen; L.L. Chen; W.G. Li; Y. Fang; G.Y. Huang
12/10/2013
COMT; Endometrial cancer; Meta-analysis; Polymorphism

Catechol-O-methyltransferase (COMT) is a critical enzyme to detoxify the carcinogenic catechol estrogen and the Val158Met polymorphism of COMT could influence its enzymatic activity. Recent epidemiological studies have investigated the correlation of COMT Val158Met polymorphism with endometrial cancer risk; however, the results are inconsistent. To better evaluate the role of ... more

G. Lin; J. Zhao; J. Wu; A. O; W.H. Zhang; Y. Zhang; L. Yu
10/30/2013
Bronchopulmonary dysplasia; Meta-analysis; MicroRNA; Profiling

Over the past several years, several microRNA (miRNA) expression profiling studies have been carried out on bronchopulmonary dysplasia (BPD) in mammalian lung tissues. The most effective way to identify these important miRNAs is to systematically search for similar signatures identified in multiple independent studies. Accordingly, a meta-analysis was conducted to review published miRNA ... more

Y. Yang; J. Qiu; Q. Kan; X.G. Zhou; X.Y. Zhou
10/24/2013
Chronic obstructive pulmonary disease; Meta-analysis; Polymorphism; Tumor necrosis factor-alpha

Chronic obstructive pulmonary disease (COPD) is a chronic systemic inflammatory disease; increasing evidence indicates that the TNF-α polymorphism is associated with progression of this disease. Few studies have focused upon association between TNF-α -238G/A or -863C/A polymorphism and COPD risk. Reported associations have been controversial because of small sample size and varied study ... more

K. Cui; X.Y. Ge; H.L. Ma
10/18/2013
External apical root resorption; Interleukin-1β; Meta-analysis; Orthodontic; Polymorphism

The purpose of this meta-analysis was to determine whether genetic variants of the interleukin-1β[+3954 C>T (rs1143634)] (IL-1β +3954 C>T) gene polymorphisms were associated with orthodontic external apical root resorption (EARR). A meta-analysis was carried out using data entered into the PubMed and Embase electronic databases before October 5, 2012. A total of 7 studies were ... more

F.L. Wu; L.Y. Wang; Y.Q. Huang; W.B. Guo; C.D. Liu; S.G. Li
10/15/2013
EPHX1 gene; Esophageal cancer; Meta-analysis; Polymorphism

Epoxide hydrolases metabolize exogenous chemicals, including carcinogens such as polycyclic aromatic hydrocarbons. The relationship between microsomal epoxide hydrolase 1 (EPHX1) polymorphisms and esophageal cancer risk has been investigated in various ethnic populations, but the results have been contradictory. We investigated the association of EPHX1 Tyr113His and ... more

J.J. Hu; Z.T. Wang; B. Li
09/23/2013
CTLA-4 gene; Diabetes; Meta-analysis; SNPs

We evaluated association of polymorphisms in the CTLA-4 gene with the risk of type 1 diabetes mellitus. Comprehensive meta-analysis was applied to case-control studies of the association between CTLA-4 and type 1 diabetes mellitus to assess the joint evidence for the association, the influence of individual studies, and evidence for publication bias. We searched PubMed ... more

J. Liu; H.X. Zhang; G.Y. Feng; L. He
09/19/2013
Gene polymorphism; Hepatocellular carcinoma; Interleukin-28B; Liver cirrhosis; Meta-analysis; rs12979860

We examined the association of the interleukin-28B (IL-28B) gene rs12979860 T/C polymorphism with development of hepatitis virus-related hepatocellular carcinoma (HCC) and liver cirrhosis (LC). Two investigators independently searched the PubMed, Elsevier, EMBASE, Web of Science, Wiley Online Library, and Chinese National Knowledge Infrastructure data bases. Pooled odds ratios (ORs) and ... more

G.J. Suo; Z.X. Zhao
09/23/2013
Cancer; Meta-analysis; MiR-499; Polymorphism

An A/G polymorphism (rs3746444) has been identified in the miR-499 gene that can change the conformation of the secondary gene structure and thereby directly affect binding to target mRNAs and the microRNA (miRNA) maturation process, thus altering protein expression and potentially contributing to cancer susceptibility. Numerous studies investigating the associa­tion between the ... more

N. Wang; Z.Q. Tian; Y. Li; R.M. Zhou; G.Y. Wang
09/23/2013
Coronary artery disease; Meta-analysis; Polymorphism

The G403A polymorphism in the RANTES (regulated on activation normal T cell expressed and secreted) gene has a key role in the expression of RANTES, which has been detected in a range of cells in atherosclerotic plaque. However, the association of this polymorphism with the risk of coronary artery disease (CAD) remains controversial. A meta-analysis was performed to assess the association ... more

K. Cui; X.Y. Ge; H.L. Ma

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