Research Article

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The glutathione S-transferases (GSTs), a family of phase II isozymes, detoxify several carcinogens. Genetic variations in GSTs have been associated with increased risk for cancer due to a heritable deficiency in detoxification pathways for environmental carcinogens. Conflicting findings have been reported about the association between constitutive GST polymorphisms and gliomas in ... more

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Brazilian population; Complement receptor-1; Duffy blood group; Genetic polymorphisms; Malaria; Toll-like receptor

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S.C. Soares; K. Abé-Sandes; V.B.Nascimento Filho; F.M.F. Nunes; W.A. Silva
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The receptor for advanced glycation end products (RAGE or AGER) is a multiligand member of the immunoglobulin superfamily. RAGE is expressed in several tissues, including human myometrium, chorionic villi and placenta. Advanced glycation end products are the best studied ligands of RAGE; they have pro-inflammatory actions in human gestational tissues, ... more

I.C.R. Santos; D.R. Daga; H.R. Frigeri; R.R. Réa; A.C.R. Almeida; E.M. Souza; F.O. Pedrosa; C.M.T. Fadel-Picheth; G. Picheth
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Association study; CYP27B1; EDN1; Genetic polymorphisms; GSTP1; Sarcoidosis

Sarcoidosis is a chronic inflammatory disease, characterized by granulomatous inflammation, prominently involving the respiratory system. The etiology of this disease has not yet been elucidated and the contribution of genetic is not yet completely understood. We searched for novel candidate genes, utilizing a system biology approach, based on data from published transcriptional, ... more

A. Maver; I. Medica; B. Salobir; M. Tercelj; B. Peterlin
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Sickle cell anemia is an affection that causes chronic inflammation, with consequences for vaso-occlusion, oxidative stress and cytokine production. Genetic polymorphisms in markers involved in this process can modulate the inflammatory response, including polymorphisms -308G/A of TNFA (tumor necrosis factor alpha) and -509C/T of TGFB1 (transforming growth factor beta 1), reported to ... more

L.S. Torres; B. Júnior; D.G. Silva; C.L. Lobo; M.A. Ruiz; C.R. Bonini-Domingos
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Asian; Caspase 8; Genetic polymorphisms; Meta-analysis; Neoplasm

Genetic variation in the CASP-8 gene reportedly can increase cancer susceptibility by regulating tumor cell proliferation and apoptosis. Several studies have investigated this possibility; however, the conclusions remain controversial. We made a Human Genome Epidemiology (HuGE) review and did a meta-analysis to explore the association between CASP-8 gene polymorphisms and cancer risk in ... more

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Acenocoumarol; APOE; CYP2C19; CYP2C9; Genetic polymorphisms; PCR-RFLP

Oral anticoagulants of the coumarin type have an inconveniently narrow therapeutic window, making their use difficult. In Mexico, genetic variables that participate in the heterogeneity of the therapeutic response remain poorly investigated. With the focus on warfarin, extensive pharmacogenomic studies have been performed, including those on the CYP450 family and APOE. The ... more

J.A. Nastasi-Catanese; J.R. Padilla-Gutiérrez; Y. Valle; F. Ortega-Gutiérrez; M.P. Gallegos-Arreola; L.E. Figuera
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Evidence is accumulating that chronic inflammation has an important role in prostate cancer. Two common polymorphisms in the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, rs20417 and rs689470, have been found to alter the risk for prostate cancer, but the various studies are not in agreement. To derive a more precise estimation of this association, all available studies were ... more

H.T. Zhang; Y. Xu; Z.H. Zhang; L. Li
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Association study; Brazilian population; Chronic myeloid leukemia; Genetic polymorphisms; Hardy-Weinberg equilibrium

Chronic myeloid leukemia is a hematopoietic stem cell disorder that causes uncontrolled proliferation of white blood cells. Although the clinical and biological aspects are well documented, little is known about individual susceptibility to this disease. We conducted a case-control study analyzing the prevalence of the polymorphisms MTHFR C677T, MTHFR A1298C, del{ ... more

G.S. Lordelo; A.L. Miranda-Vilela; A.K. Akimoto; P.C.Z. Alves; C.O. Hiragi; A. Nonino; M.B. Daldegan; M.N. Klautau-Guimarães; C.K. Grisolia

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