Research Article

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03/30/2007

Associations of DNA polymorphisms in growth hormone and its transcriptional regulators with growth and carcass traits in two populations of Brangus bulls

Brangus; Carcass; DNA; Growth; Growth hormone; SNP

Sequence polymorphisms in the growth hormone (GH) gene and its transcriptional regulators, Pit-1 and Prop-1, were evaluated for associations with growth and carcass traits in two populations of Brangus bulls Chihuahuan Desert Rangeland Research Center (CDRRC, N = 248 from 14 sires) and a cooperating breeding program (COOP, N = 186 from 34 sires). Polymorphisms were SNP mutations in intron 4 (C ... more

M.G. Thomas; R.M. Enns; K.L. Shirley; M.D. Garcia; A.J. Garrett; G.A. Silver
07/25/2006

Evaluation of DNA polymorphisms involving growth hormone relative to growth and carcass characteristics in Brahman steers

Brahman; Carcass; DNA; Genetic marker; Growth; Growth hormone

Associations of DNA polymorphisms in growth hormone (GH) relative to growth and carcass characteristics in growing Brahman steers (N = 324 from 68 sires) were evaluated. Polymorphisms were an Msp-I RFLP and a leucine/valine SNP in the GH gene as well as a Hinf-I RFLP and a histidine/arginine SNP in transcriptional regulators of the GH gene, Pit-1 and Prop-1. Genotypic frequencies of ... more

V.R. Beauchemin; M.G. Thomas; D.E. Franke; G.A. Silver
08/26/2011

Single nucleotide polymorphisms in the growth hormone and insulin-like growth factor-1 genes are associated with milk production, body condition score and fertility traits in dairy cows

Dairy cattle; Fertility; Growth hormone; IGF-1; Single nucleotide polymorphism

The somatotrophic axis (GH-IGF) is a key regulator of animal growth and development, affecting performance traits that include milk production, growth rate, body composition, and fertility. The aim of this study was to quantify the association of previously identified SNPs in bovine growth hormone (GH1) and insulin-like growth factor 1 (IGF-1) genes with direct ... more

M.P. Mullen; C.O. Lynch; S.M. Waters; D.J. Howard; P. O’Boyle; D.A. Kenny; F. Buckley; B. Horan; M.G. Diskin
11/09/2010

Sequence analysis of the growth hormone gene of the South American catfish Rhamdia quelen

Bioinformatics; Growth hormone; Primer walking; Rhamdia quelen; Siluriformes

Rhamdia quelen is an important Neotropical catfish species for fisheries and aquaculture in southern Brazil, where it is called Jandia. Like other native Brazilian species of economic importance, R. quelen genetics needs more attention for animal breeding programs. The growth hormone gene is known to be linked to a number of molecular markers and quantitative trait loci ... more

B.S. Vaz; G.M. Cerqueira; J.C. Silva; V.H.B. Manzke; C.G.A. Moreira; H.L.M. Moreira
06/01/2010

Survival of the thriftiest: restricted nurture reveals the thrifty nature of a growth gene in Bos indicus

Bos indicus; Dietary restriction; Growth hormone; Longevity; marker-assisted selection; Thrifty gene

Growth hormone (GH) is a part of the somatotropic axis that controls metabolism, growth, development and aging in a wide range of animals. Mutations that reduce GH signaling have been associated with extended life spans and increased longevity in ways similar to what is observed in dietary restriction (DR) models. However, the mechanism by which DR works is not well understood. Here, we ... more

S.U. Dani; M.A.C. Dani; I.L. Freire; S.P. Gouvea; F.B. Knackfuss; F.P. Lima; M.E.Z. Mercadante; E. Monteiro; S.M.G. Paggiaro; A.G. Razook; H.C. Yehia
05/30/2014

Construction and functional study of pGN, a mammary gland-specific expression plasmid

Bcap-37 cell line; Goat mammary gland; Growth hormone; pGN plasmid

The aim of this study was to construct a mammary gland-specific expression vector, pGN, and to validate its function in expressing growth hormone (GH) both in vitro and in vivo. First, the GH gene was amplified and inserted downstream of the b-casein 5'-arm. Next, the neo gene was cloned downstream of the b-casein 3'-arm as a selection marker. To analyze the ... more

J. Lin; Q.H. Yu; Q. Zhang; Q. Yang