Research Article

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10/25/2012
Cell cycle; Copper stress; Schizosaccharomyces pombe

Because of its specific electrochemical properties, copper is an essential heavy metal for living organisms. As with other heavy metals, high levels can provoke damage. We examined gene expression under copper stress in wild-type fission yeast (Schizosaccharomyces pombe) through differential display. After the EC50 concentration of CuSO4 was ... more

C. Tarhan; A.T. Sarikaya
08/24/2012
Anaphase-promoting complex; Cell cycle; Cell proliferation; siRNA

Anaphase-promoting complex/cyclosome (APC/C) is a key E3 ubiquitin ligase in cell division, which catalyses ubiquitination of cell-cycle regulators. Studying this complex could reveal important information regarding its application in cancer research and therapy. In this study, 4 synthesized small interfering RNAs (siRNAs) were transfected into HEK293T cells to suppress messenger RNA ( ... more

Y.J. Shi; K.K. Huo
08/26/2014
Cell cycle; Endometriosis; Gene polymorphism; p53; TP53

We evaluated the association between TP53 gene polymorphisms and endometriosis in Brazilian women. Genomic DNA was extracted from swabs of buccal cells collected from hospital patients. TP53 gene polymorphisms were investigated at three codons: TP53*11 Glu/Gln or Lys (GAG->CAG or AAG), TP53*72 Arg/Pro (CCG->CCC), and TP53*248 Arg/Thr (CGG ... more

C.M. Camargo-Kosugi; P. D’Amora; J.P.F.O. Kleine; C.V. Carvalho; H. Sato; E. Schor; I.D.C.G. Silva
03/24/2014
Apoptosis; Cell cycle; Gax; Migration; Proliferation; VSMCs

The Gax gene has been implicated in a variety of cell-developmental and biological processes, and aberrant Gax expression is linked to many diseases. In this study, to provide important insights for Gax-based gene therapy in vein graft restenosis and its anti-restenotic mechanism, we used rabbit vascular smooth muscle cells (VSMCs) to investigate the effects of ... more

H. Zheng; S. Xue; Z.L. Hu; J.G. Shan; W.G. Yang
06/18/2015
Cell apoptosis; Cell cycle; Cell proliferation; Cervical cancer; Forkhead box protein 01; Immunohistochemistry

Forkhead box protein O1 (FOXO1) is an important transcriptional regulator of cell proliferation, and is considered essential for tumor growth and progression. However, the function of FOXO1 in human cervical cancer remains unclear. In this study, we investigated the role of FOXO1 in cervical cancer. Our results showed that FOXO1 expression was lower in cervical cancer than in cervical ... more

B. Zhang; L.S. Gui; X.L. Zhao; L.L. Zhu; Q.W. Li
01/15/2015
Apoptosis; BPH-1 cells; Cell cycle; Croton membranaceus; Proliferation

Croton membranaceus aqueous root extract (CMARE) is among the widely used phytotherapeutics in Ghana for the management of benign prostatic hyperplasia (BPH) and prostate cancer. However, the mechanism of action of CMARE remains to be elucidated. This study aimed to establish whether apoptosis is involved in the antiproliferative effect of CMARE on human BPH-1 cells. We ... more

D.K. Afriyie; G.A. Asare; K. Bugyei; J. Lin; J. Peng; Z. Hong
10/05/2007
Genetic polymorphism; Leptin; Leptin receptor; Obesity; β3-adrenergic receptor

Obesity is due to the combined effects of genes, environment, lifestyle, and the interactions of these factors. The adrenergic receptor β3 (β3-AR), leptin (LEP) and leptin receptor (LEPR) genes have been intensively evaluated in the search of variants that could be related to obesity and its cardiometabolic complications. The results of most of these studies have ... more

S.F.P. Duarte; E.A. Francischetti; V.A. Genelhu; P.H. Cabello; M.M.G. Pimentel
09/09/2011
Aging; Apolipoprotein E; Brazilian-Japanese elderly; Cardiovascular risk; Longevity; Obesity

Study of immigrant populations may contribute to a better understanding of the epidemiology of diseases associated with the aging process. We examined the prevalence of cardiovascular risk factors, including apolipoprotein E (ApoE) polymorphism, in elderly subjects who were born in Japan, migrated to South Brazil and have lived in that region for over 40 years, versus a group of elderly, ... more

N. Terra; Y. Moriguchi; L. Bittencourt; R.S. Trois; J.E.C. Piccoli; I.B.M. Cruz
06/07/2011
BMI; Leptin; MC4R gene; Obesity

Mutations in the melanocortin-4 receptor (MC4R) are associated with severe obesity, independent of their effect on cortisol or thyroid-stimulating hormone levels. We examined a morbidly obese male (BMI = 62 kg/m2) with a binge-eating disorder and eight family members for mutations in the MC4R gene and potential differences in leptin levels. Fifty healthy individuals served as ... more

S. Buchbinder; U. Bärtsch; M. Müller; M. Zorn; P.P. Nawroth; T. Schilling
07/20/2010
Adiponectin; Adrenergic receptor; Cardiometabolic risk factor; Obesity; Polymorphism

We determined whether ADRβ3 polymorphism is associated with obesity-related traits in 140 obese patients. Molecular analysis was performed by PCR and RFLP. Individuals carrying the Arg64 allele had a lower waist-to-hip ratio, higher adiponectin and high-density lipoprotein cholesterol levels, and a tendency towards lower blood pressure. In contrast, Trp64/Trp64 carriers ... more

V.A. Genelhu; E.A. Francischetti; S.F.P. Duarte; B.M.J. Celoria; R.C. Oliveira; P.H. Cabello; M.M.G. Pimentel

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