Research Article

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05/16/2014
Atherosclerosis; Global DNA methylation; Homocysteine; Lectin-like oxidized LDL receptor-1

Homocysteine (Hcy) is an independent risk factor of atherosclerosis through its involvement with the methionine cycle. In this study, we aimed to determine the blood vessel global methylation rate in Hcy-induced atherosclerosis in apolipoprotein-E-deficient (ApoE-/-) mice, and to explore the possible mechanism of this change in endothelial cells. ApoE-/- mice were divided into a ... more

X.L. Yang; J. Tian; Y. Liang; C.J. Ma; A.N. Yang; J. Wang; S.C. Ma; Y. Cheng; X. Hua; Y.D. Jiang
06/01/2015
Angiotensin-1; Atherosclerosis; Endothelial nitric oxide synthase; Endothelin-1; Vascular function

We investigated the therapeutic effect of Xin Mai Jia (XMJ) on atherosclerosis (AS) in rats. Rat models of AS were estab­lished by peritoneally injecting vitamin D, feeding a high-fat diet, and inducing balloon injuries in rats. The stomachs of the rats were irrigated continuously for 10 weeks with XMJ. Blood lipid- and hemorheology-related indices of blood samples were detected. Pathological ... more

P. Li; G.P. Pan; M. Jia; Q.Q. Wang; Z.G. Guo; F.R. Zhao; G.L. Lei; G.R. Wan; G.M. Wan
05/04/2015
Atherosclerosis; Diabetes mellitus; Diabetic foot; High mobility group box 1; Peripheral arterial occlusive disease

The role of high mobility group box 1 (HMGB1) has been demonstrated in stroke and coronary artery disease but not in peripheral arterial occlusive disease (PAOD). The pathogenesis of HMGB1 in acute and chronic vascular injury is also not well understood. We hypothesized that HMGB1 induces inflammatory markers in diabetic PAOD patients. We studied 36 diabetic patients, including 29 ... more

C.F. Tsao; W.T. Huang; T.T. Liu; P.W. Wang; C.W. Liou; T.K. Lin; C.J. Hsieh; S.W. Weng
09/30/2004
Cancer; DmtDNA4977; In situ PCR; Kerns-Sayre syndrome deletion mutation; Mitochondria; Mitochondrial DNA; Real-time PCR

Levels of mtDNA4977 deletions (DmtDNA4977) have been found to be lower in tumors than in adjacent non-tumoral tissues. In 87 cancer patients, DmtDNA4977 was detected by multiplex polymerase chain reaction (PCR) amplification in 43 (49%) of the tumors and in 74 (85%) of the samples of non-tumoral tissues that ... more

M.Angela C. Dani; S.U. Dani; S.P.G. Lima; A. Martinez; B.M. Rossi; F. Soares; M.A. Zago; A.J.G. Simpson
05/09/2007
African Americans; American Caucasians; Brazilians; Mitochondrial DNA; Y-chromosome

We have previously shown evidence of strong sex-biased genetic blending in the founding and ongoing history of the Brazilian population, with the African and Amerindian contribution being highest from maternal lineages (as measured by mitochondrial DNA) and the European contribution foremost from paternal lineages (estimated from Y-chromosome haplogroups). The same phenomenon has been ... more

V.F. Gonçalves; F. Prosdocimi; L.S. Santos; J.M. Ortega; S.D.J. Pena
01/29/2007
Melipona mondury; Melipona rufiventris; Meliponini; Mitochondrial DNA; Polymorphic site; RFLP

Within the Meliponini, a widely distributed group of stingless bees, Melipona rufiventris has been considered as a single, cohesive species. Recently, analysis of morphological characters led to the splitting of this species into two species, M. mondury and M. rufiventris. The former occurs in the Atlantic Rain Forest ranging from Santa Catarina to Bahia ... more

G.S. Barni; R. Strapazzon; J.C.V. Guerra; G. Moretto
03/03/2009
allele-specific polymerase chain reaction; Bovine; maternal inheritance; Mitochondrial DNA

The Canchim (5/8 Charolais + 3/8 Zebu) beef cattle breed was developed at Southeast-Embrapa Cattle to take advantage of hybrid vigor and to combine the higher growth rate and beef quality of Charolais with tropical adaptations of Zebu. The development of three lineages (old, new, and crossbred) has increased its genetic basis. The genotypic origin (Bos taurus or Bos indicus) ... more

S.C. Méo; C.R. Ferreira; M.R. Chiaratti; F.V. Meirelles; L.C.A. Regitano; M.M. Alencar; P.F. Barbosa
12/16/2008
Conservation; Endangered species; Mitochondrial DNA; Oryx; Phylogenetic relationship

The present study reports the application of mitochondrial markers for the molecular phylogeny of Oryx species, including the Arabian oryx (AO), scimitar-horned oryx (SHO) and plains oryx (PO), using the Addax as an outgroup. Sequences of three molecular markers, 16S rRNA, cytochrome b and a control region, for the above four taxa were aligned and the topologies of respective ... more

H.A. Khan; I.A. Arif; A.A.Al Homaidan; A.H.Al Farhan
02/25/2009
Mitochondrial DNA; Polymorphism; Sea turtles; Single strand conformation polymorphism

Marine turtles are increasingly being threatened worldwide by anthropogenic activities. Better understanding of their life cycle, behavior and population structure is imperative for the design of adequate conservation strategies. The mtDNA control region is a fast-evolving matrilineal marker that has been employed in the study of marine turtle populations. We developed and tested a simple ... more

E.C. Reis; R.M. Albano; A.C.V. Bondioli; L.S. Soares; G. Lôbo-Hajdu; G. Lôbo-Hajdu
10/14/2008
A3243G mutation; Mitochondria; Mitochondrial disorders; Mitochondrial DNA; Transmitochondrial; Transmitochondrial mice

The mitochondrial A3243G tRNALeu(UUR) mutation associated with a variety of mitochondrial disorders results in a severe respiratory deficiency, an increase in reactive oxygen species (ROS) production and activities of anti-oxidative enzyme in vitro. However, the phenotypic implications of this mutation have not been described in vivo. Here, mitochondria carrying A3243G ... more

J. Li; K. Zhou; X. Meng; Q. Wu; S. Li; Y. Liu; J. Wang

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