Research Article

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12/30/2004
Computational data mining; Database; Homology modeling; HORDE; Olfactory receptor; Sequence analysis

Olfactory receptors (ORs) constitute the largest gene-family in the vertebrate genome. We have attempted to provide a comprehensive view of the OR universe through diverse tools of bioinformatics and computational biology. Among others, we have constructed the Human Olfactory Receptor Data Exploratorium (HORDE, http:// ... more

T. Olender; E. Feldmesser; T. Atarot; M. Eisenstein; D. Lancet
08/28/2014
Database; Foxtail millet; Gene clusters; Nucleotide-binding site; Phylogenetic tree

The nucleotide-binding site (NBS) disease-resistance genes are the largest category of plant disease-resistance gene analogs. The complete set of disease-resistant candidate genes, which encode the NBS sequence, was filtered in the genomes of two varieties of foxtail millet (Yugu1 and ‘Zhang gu’). This study investigated a number of characteristics of the putative NBS genes, such as ... more

Y.B. Zhu; X.Q. Xie; Z.Y. Li; H. Bai; L. Dong; Z.P. Dong; J.G. Dong
11/08/2011
MicroRNA; Non-invasive prenatal diagnosis; Preeclampsia

Preeclampsia continues to be a mortal disease of pregnant women throughout the world. Recently, geneticists, allied with obstetricians, have opened new frontiers. MicroRNAs (miRNAs) are members of a class of small, noncoding RNA molecules. They are critical posttranscriptional regulators of gene expression. We extracted circulating miRNA from maternal plasma and quantified mir-152 and mir ... more

T. Gunel; Y.G. Zeybek; P. Akçakaya; I. Kalelioglu; A. Benian; H. Ermis; K. Aydinli
12/02/2013
Gene expression microarray; MicroRNA; Prediction program; Target genes

MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides in length, which play important roles in regulating gene expression post-transcriptionally. Several computational methods and algorithms have been developed to predict miRNA targets. In this study, we described a method that can be used to integrate miRNA target prediction data from multiple sources and gene ... more

B. Cao; T. Ji; B. Zhou; J. Zou; G.Q. Jiao
11/07/2013
3T3-L1 preadipocyte; Adipocyte differentiation; AP-1; FABP4; MicroRNA

We examined the effect of microRNAs on 3T3-L1 adipocyte differentiation and expression of adipocyte-specific gene fatty acid-binding protein 4 (FABP4). We screened and identified adipo-related microRNAs during 3T3-L1 adipocyte differentiation with a microRNA microarray. High expression plasmids of miR-24 and miR-21 were constructed and transfected into 3T3-L1 preadipocytes by ... more

M. Kang; L.M. Yan; Y.M. Li; W.Y. Zhang; H. Wang; A.Z. Tang; H.S. Ou
10/30/2013
Bronchopulmonary dysplasia; Meta-analysis; MicroRNA; Profiling

Over the past several years, several microRNA (miRNA) expression profiling studies have been carried out on bronchopulmonary dysplasia (BPD) in mammalian lung tissues. The most effective way to identify these important miRNAs is to systematically search for similar signatures identified in multiple independent studies. Accordingly, a meta-analysis was conducted to review published miRNA ... more

Y. Yang; J. Qiu; Q. Kan; X.G. Zhou; X.Y. Zhou
10/07/2013
MicroRNA; Northern blot; UV-B radiation; Wheat

MicroRNAs (miRNAs) play critical roles in post-transcriptional gene regulation and act as important endogenous regulators to various stressors. Ultraviolet-B (UV-B) radiation is a major factor influencing crop growth and development. In this study, we isolated a novel wheat miRNA, named Tae-miR6000, and confirmed its expression diversity after UV-B treatments. Additionally, using the ... more

B. Wang; Y.F. Sun; N. Song; X.J. Wang; H. Feng; L.L. Huang; Z.S. Kang
12/04/2014
Alzheimer’s disease; Meta-analysis; MicroRNA; Oxidized low density lipoprotein receptor 1; Polymorphism

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that contributes to dementia in the elderly population. Genome-wide linkage analysis has identified chromosome 12p as the AD-susceptible region, which includes lectin-like oxidized low-density lipoprotein receptor 1 (OLR1). The OLR1 +1073 C/T single-nucleotide polymorphism is located in the 3'- ... more

Y. Kong; J.B. Wu; X. Wang; J.F. Zhao; H. Song; L.D. Yuan
10/20/2014
Interaction network; MicroRNA; Trefoil factor 2 knock-out

Trefoil factors, which bear a unique 3-loop trefoil domain, are a family of small secretory protease-resistant peptides (7-12 kDa) discovered in the 1980s. Trefoil factor 2 (TFF2) is a unique member of trefoil factors family that plays important roles in gastrointestinal mucosal defense and repair. However, few studies have characterized the miRNA expression patterns in TFF2 knock-out ... more

Y. Yin; H.Q. Shan; W. Huang; Y.M. Wu; H. Lu; Y. Jin
07/04/2014
Hepatocellular carcinoma; MicroRNA; Polymorphisms

We investigate the potential association of miR-149C>T and miR-499A>G polymorphisms and the risk of hepatocellular carcinoma (HCC). A matched case-control study of 152 cases and 304 controls were conducted. The miR-149C>T and miR-499A>G genotypes were analyzed using duplex polymerase chain reaction with restricted fragment length polymorphism. HCC patients were more likely to ... more

X.H. Wang; F.R. Wang; Y.F. Tang; H.Z. Zou; Y.Q. Zhao

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