Research Article

Related GMR Articles

Haplogroup; Lung cancer; Mitochondrial DNA; Somatic mutation

Mitochondrial DNA mutations play crucial roles in the pathogenesis and progression of human malignancies. Therefore, to determine whether maternal background or mitochondrial DNA somatic mutations were essential cofactors in the lung cancer of Chinese patients as well, the complete mitochondrial DNA displacement loop of the primary cancerous, matched para-cancerous normal and distant ... more

Y. Fang; H.Y. Yang; Y.H. Shi; J.H. Cui; L.Y. Li; Y.C. Xu; J.L. Shao
Colorectal cancer risk; Genotype; Haplotype; MTHFR

Methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, C677T and A1298C have been associated with several diseases, including cancer. We made a case-control study to analyze a possible association of MTHFR gene polymorphisms C677T and A1298C ... more

H. Li; W.L. Xu; H.L. Shen; Q.Y. Chen; L.L. Hui; L.L. Long; X.L. Zhu
FMF; Haplotype; MDR1; Polymorphism; Turkey

The multidrug resistance (MDR1) gene encodes a P-glycoprotein that plays a key role in drug bioavailability and response to drugs in different human populations. More than 50 SNPs have been described for the MDR1 gene. Familial Mediterranean fever (FMF) is considered an autosomal recessive hereditary disease, associated with a single gene named the Mediterranean fever gene (MEFV). However ... more

A. Rüstemoglu; G. Gümüş-Akay; S. Yigit; T. Tasliyurt
China (CHB); Chinese Han in Beijing; Haplotype; Linkage disequilibrium; Tibetan; UGT1A

As part of a series of pharmacogenomics studies of the Chinese population, we investigated genetic polymorphisms of some UGT1A regions. The three genes that were analyzed were UGT1A9, 1A7, and 1A1; we sequenced their exons, together with promoters, surrounding introns and 3'-untranslated regions (3ꞌUTR) in 100 unrelated-healthy Chinese Tibetan individuals. We compared the data with ... more

W. Yan; Y.W. Wang; F.F. Yang; M. Wang; X.Q. Zhang; J. Dong; E. Chen; J. Yang
Haplotype; Male infertility; Single nucleotide polymorphism; UBE2B

The ubiquitin-conjugating enzyme 2B gene (UBE2B) is involved in the regular and symmetric organization of the fibrous sheath of sperm flagella. This study aimed to examine the relationship between single nucleotide polymorphisms (SNPs) in UBE2B and infertility in Northeast Chinese men. We carried out a polymerase chain reaction-restriction fragment length polymorphism ... more

Y. Hu; W. Wen; J.G. Yu; S.Q. Qu; S.S. Wang; J. Liu; B.S. Li; Y. Luo
Chinese Hui population; Haplotype; Polymorphism; Rheumatoid arthritis; TIM-1

The T-cell immunoglobulin and mucin domain 1 (TIM-1) is known to be associated with susceptibility to rheumatoid arthritis (RA). We investigated the association of four single-nucleotide polymorphisms (SNPs) in the promoter region of the TIM-1 gene with susceptibility to RA in a Chinese Hui ethnic minority group. Using RFLP or sequence specific primer-PCR, 118 RA patients and 118 non- ... more

J.R. Xu; Y. Yang; X.M. Liu; J.Y. Sun; Y.J. Wang
Cattle; Haplotype; Polymorphism; Short tandem repeat; Y-chromosome

The aim of this study is to use Y-chromosome gene polymorphism method to investigate regional differences in genetic variation and population evolution history of the Chinese native cattle breeds. Six Y-chromosome short tandem repeat (Y-STR) loci (UMN0929, UMN0108, UMN0920, INRA124, UMN2404, and UMN0103) were analyzed using 1016 healthy ... more

Y.P. Xin; L.S. Zan; Y.F. Liu; W.Q. Tian; H.B. Wang; G. Cheng; A.N. Li; W.C. Yang
Haplotype; Kazakh; Linkage disequilibrium; Metabolic syndrome; Polymorphism; PPARγ

We investigated the relationship between haplotype and linkage disequilibrium of the PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 and metabolic syndrome (MS) in the Kazakh people of Xinjiang Province. For PPARγ, rs3856806, rs12490265, rs1797912, and rs1175543 genotypes were detected in 489 subjects (including 245 MS patients and 244 controls) using matrix- ... more

S.X. Guo; H. Guo; R.L. Ma; Y.S. Ding; J.Y. Zhang; J.M. Liu; M. Zhang; Q. Niu; N. Qiang; S.G. Li; C.N. Qi
Dopamine; DRD5; Haplotype; Paranoid schizophrenia; SNP

Dopamine (DA) has been implicated in the pathophysiol­ogy of several psychiatric disorders, including schizophrenia. Thus, genes related to the dopaminergic (DAergic) system are good candidate genes for schizophrenia. One of receptors of the DA receptor system is dopa­mine receptor 5 (DRD5). Single nucleotide polymorphisms (SNPs) in the regulatory regions of DRD5 gene may affect ... more

Y. Zhao; M. Ding; H. Pang; X.M. Xu; B.J. Wang
5-HT; Haplotype; Paranoid schizophrenia; Serotonin; SNP; TPH2

In the last years, serotonin (5-HT) has been related with the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the serotonergic (5-HTergic) system are good candidate genes for schizophrenia. The rate-limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2). Single nucleotide polymorphisms (SNPs) in the regulatory regions of TPH2 ... more

X.M. Xu; M. Ding; H. Pang; B.J. Wang