Review

Related GMR Articles

10/20/2014
Chronic intermittent hypoxia; Gender difference; Isobaric tag for relative and absolute quantitation; Obstructive sleep apnea; Proteomics; Vascular injury

Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular diseases such as systemic arterial hypertension, ischemic heart disease, stroke, heart failure, atrial fibrillation, and cardiac sudden death. The pathogenesis of cardiovascular disease in OSA is thought to be induced primarily by chronic intermittent hypoxia (CIH), a specific pattern of change in oxygenation ... more

Q.Y. Li; Y. Feng; Y.N. Lin; M. Li; Q. Guo; S.Y. Gu; J.L. Liu; R.F. Zhang; H.Y. Wan
01/10/2014
Drug target; Gene medicine; Genomics; Proteomics

Gene medicine is making breakthroughs in health questions that have baffled humanity for centuries. To understand and utilize gene medicine, it is necessary to realize its action against targets at the molecular level. Currently, many methods can be used to discover drug targets; among these, genomic and proteomic methods are the two most important. In this study, we introduced how to ... more

H.M. Zhang; Z.R. Nan; G.Q. Hui; X.H. Liu; Y. Sun
06/01/2015
Cyld knockout; iTRAQ; Kidney disease; Proteomics

The aim of this study was to compare the proteomics pattern of the kidneys from Cyld knockout mice with that from normal mouse kidneys and establish a preliminary understanding of the role of Cyld in the kidney. Proteins from the kidneys of knockout Cyld mice and wild-type mice were extracted, isobaric tags for relative and absolute quantitation (iTRAQ) was ... more

Y. Zhao; Y. Zhang; H.B. Song; F. Wu; X.L. Wang; S.C. Sun; T.X. Cui; D.Q. Tang
01/23/2015
Proteomics; Two-dimensional gel electrophoresis; Type III brush hair; Yangtze River Delta white goat

The Yangtze River Delta white goat is a goat breed that can produce high quality brush hair (Type III hair) around the world. This study aimed to compare Type III hair and non-Type III hair goat skin tissues using differentially expressed proteins based on 2-dimensional gel electrophoresis technology. The differentially expressed protein spots were analyzed using the PDquest 8.0 software ... more

B. Yang; M.Y. Cai; Y.J. Li; H. Zhang; G.H. Cheng; J.H. Zhang; G.J. Zhang; W.T. Li; D.J. Ji
01/16/2015
Lipopolysaccharide; Low rumen pH; Proteomics

The aim of this study was to analyze the response of dry goat liver to sub-acute ruminal acidosis induced by a highly concentrated diet. Non-pregnant, non-lactating female Poll-goats (N = 12) were randomly assigned to either a high-concentrate (HG) or a low-concentrate (LG) diet. Low rumen pH was successfully induced with HG (more than 3 h with rumen pH < 5.8). The plasma ... more

Z. Xie; X. Jiang; P. Ye; Y. Zhang; Y. Ni; S. Zhuang; X. Shen
08/13/2012
Alkalinity stress; Microarray; Oryzias latipes; Transcriptomics

Oryzias latipes (Adrianichthyidae), known as Japanese medaka or Japanese killifish, is a small 2-4 cm long fish common in rice paddies in coastal Southeast Asia and is also a popular aquarium fish. It has been widely used as a research model because of its small size and because it is very easy to rear. Alkalinity stress is considered to be one of the major stressors on fish in ... more

Z.L. Yao; H. Wang; L. Chen; K. Zhou; C.Q. Ying; Q.F. Lai

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