Research Article

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02/19/2008
Breast cancer; Chemotherapy; P-glycoprotein; Polymorphism

Primary chemotherapy is a useful strategy for the treatment of locally advanced breast cancer and therefore allows in vivo evaluation of the action of cytotoxic drugs and the possibility of accomplishing conservative breast surgeries, as well as the early treatment of metastasis. Mechanisms of resistance to the drugs include the action of protein associated with the efflux of drugs from ... more

F.F.O. Rodrigues; R.E. Santos; M.B. Melo; M.A.L.G. Silva; A.L. Oliveira; R.L. Rozenowicz; L.B. Ulson; T. Aoki
12/08/2011
Breast cancer; Chondroitin sulfate; Chondroitinase ABC; Metastasis; Orthotopic tumor

Breast cancer is one of the leading causes of cancer-related deaths amongst women in the USA. The tumor microenvironment has been suggested to be an attractive therapeutic target for treatment of cancers. The glycosaminoglycan chondroitin sulfate, as part of the cellular microenvironment, consists of long linear chains of repeating disaccharide units, which are covalently attached to core ... more

R.D. Prinz; C.M. Willis; A. Viloria-Petit; M. Klüppel
12/08/2011
Breast cancer; CYP2C19; Genetics; Polymorphism

Cytochrome P450 (CYP) 2C19 metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids, which significantly promote proliferation of cancer cells in vitro and in vivo. We looked for a possible association between human CYP2C19*3 gene polymorphism and breast cancer in the Chinese Han population. In a Chinese Han case-control study of breast cancer ... more

C.Q. Gan; X.Y. Wang; Y.D. Cao; W.X. Ye; H. Liu; Y.Y. Sun
08/31/2010
Breast cancer; D‑loop; mtDNA; Polymorphism

A high incidence of somatic mtDNA polymorphisms has been reported in a wide variety of human cancers; some of them have been proposed as markers for the early detection of breast cancer. However, little attention has been paid to the potential of germline mitochondrial sequence variations as genetic risk factors for cancer. We performed a case-control study of 70 unrelated Tunisian women ... more

Y. Loueslati; W. Troudi; L. Cherni; K.B. Rhomdhane; L. Mota-Vieira
06/11/2010
Breast cancer; Drug therapy; Genetic; Glutathione transferase; Polymorphism

The glutathione S-transferase (GST) family consists of phase II detoxification enzymes that catalyze the conjugation of toxic substances, such as chemotherapeutic agents, to glutathione. We examined whether GSTT1/GSTT1“null”, GSTM1/GSTM1“null” and GSTP1Ile105Ile/GSTP1Ile105Val polymorphisms are associated with different response rates to neoadjuvant ... more

A.L. Oliveira; F.F.O. Rodrigues; R.E. Santos; T. Aoki; M.N. Rocha; C.A. Longui; M.B. Melo
01/12/2010
Breast cancer; C3435T polymorphism; MDR1 gene; Multidrug resistance; Real-time polymerase chain reaction

One of the limitations in the treatment of cancer patients with chemotherapy is the development of multidrug resistance (MDR). A well-known mechanism responsible for drug resistance is over-expression of ABC-transporter genes such as MDR1. This gene encodes p-glycoprotein (P-gp), a transmembrane glycoprotein that transports many hydrophobic substrates and anti-cancer drugs out of the cell ... more

M. Taheri; F. Mahjoubi; R. Omranipour
11/18/2013
-308G>A; Breast cancer; Mexican population; Obesity; Risk factor; Tumor necrosis factor alpha

The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes of 294 healthy Mexican women with ... more

G. Flores-Ramos; E. De Dios; A.M. Puebla-Pérez; L.E. Figuera-Villanueva; A. Ramos-Silva; R. Ramírez-Patiño; J.I. Delgado-Saucedo; E. Salas-González; G.M. Zúñiga-González; A. Alonzo-Rojo; I. Gutiérrez-Hurtado; M.P. Gallegos-Arreola
11/07/2013
Breast cancer; C-erbB-2; CCR5; Immunohistochemistry; Ki-67; Prognostic indicator

We designed a 2-stage study to investigate chemotactic factor receptor 5 (CCR5) gene expression in breast cancer tissues and axillary lymph nodes and analyze the association between the CCR5-Δ32 gene polymorphism and the clinical features and prognosis of breast cancer patients. The first stage examined 72 cases of invasive ductal carcinoma and axillary lymph ... more

Y. Zhang; F.Y. Meng; W.L. Li; C.X. Zhou; Z. Guan; H.Y. Fan
01/04/2013
Breast cancer; Chromosome 17; FISH; Metastasis; TP53 gene

Breast cancer is the second most common origin of brain metastases, after lung cancer, and represents 14-20% of all cases. Abnormalities of chromosome 17 are important molecular genetic events in human breast cancer, and several oncogenes and tumor suppressor genes are located on this chromosome. In about half of all human cancers, the tumor suppressor gene TP53, located at 17p13 ... more

D.S. Vasconcelos; F.P.E. da Silva; L.G. Quintana; N.P. Anselmo; M.A.K. Othman; T. Liehr; E.H.C. de Oliveira
12/17/2012
Breast cancer; DNMT; Single nucleotide polymorphism; susceptibility

Patterns of DNA methylation are established and maintained by a family of DNA methyltransferases (DNMTs). Aberrant promoter DNA methylation of tumor suppressor genes is found in breast cancer. Association studies between DNMT gene polymorphisms and breast cancer in various populations have reported inconsistent results. This study assessed the associations of single nucleotide ... more

M.Y. Sun; X.X. Yang; W.W. Xu; G.Y. Yao; H.Z. Pan; M. Li

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