Research Article

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08/06/2012
Association study; Body mass index; CYP17; Obesity

The cytochrome P450c17α gene (CYP17) encodes a key biosynthesis enzyme of estrogen, which is critical in regulating adipogenesis and adipocyte development in humans. We therefore hypothesized that CYP17 is a candidate gene for predicting obesity. In order to test this hypothesis, we performed a family-based association test to investigate the relationship between the ... more

H. Yan; Y. Guo; T.L. Yang; L.J. Zhao; H.W. Deng
05/16/2014
Body mass index; Middle-aged; Obesity; Overweight; Prevalence; Risk factors

In this study, a survey was conducted through questionnaire distribution and physical examinations were performed in 10,150 residents that were over 40 years old in Luzhou city. Respondents were selected by the multi-stage sampling method. The mean body mass index (BMI) of the sample population was 23.9 ± 3.3 kg/m2. Among men, BMI showed a negative relationship with increasing ... more

J. Zeng; Q. Wan; X. Bai; X.Z. Li; F. Liu; C. Li; X.Y. Liu; Y. Wang
10/20/2014
ADRB2 gene polymorphisms; Body mass index; Obesity; Obstructive sleep apnea syndrome; Restriction fragment length polymorphism; Turkish population

We determined the distribution of the Arg16Gly and Gln27Glu polymorphisms of the beta-2 adrenergic receptor gene (ADRB2) in patients with obstructive sleep apnea syndrome as well as a control group in Northeastern Turkey. A total of 52 patients diagnosed with obstructive sleep apnea in a sleep laboratory and 78 control subjects were examined. Peripheral blood samples were taken ... more

İ. Gök; İ. Çelebi; N. Hüseyinoğlu; C. Özic
08/28/2014
Diabetes; Lipase; Obesity

The aim of this study was to detect the serum adipose triglyceride lipase (ATGL) levels in obesity and newly diagnosed type 2 diabetes patients, and to explore the association between ATGL with glucose and lipid metabolism. We enrolled 66 patients with type 2 diabetes and 48 patients with normal glucose regulation, who were divided into an overweight or obese subgroup and a normal weight ... more

L. Yang; S.J. Chen; G.Y. Yuan; L.B. Zhou; D. Wang; X.Z. Wang; J.J. Chen
07/04/2014
Insulin-induced gene 2; Obesity; Single nucleotide polymorphism

A genome-wide association study showed that the tagging single nucleotide polymorphism (SNP) rs7566605 in the insulin-induced gene 2 (INSIG2) was associated with obesity. Attempts to replicate this result in different populations have produced inconsistent findings. We aimed to study the association between the rs7566605 SNP with obesity and other metabolic parameters in ... more

Y.D. Apalasamy; F.M. Moy; S. Rampal; A. Bulgiba; Z. Mohamed
04/03/2014
Body mass index; Children; Obesity; Renal function; Serum creatinine

This study was designed to analyze the relationship between serum creatinine and body mass index in children in Xinjiang, China. We used a stratified sampling method to select 5222 children aged 6-17 years in 3 areas in Xinjiang and then measured serum creatinine with an enzymatic method. Our analysis showed that the mean serum creatinine of the various age groups differed, and the ... more

X.M. Li; Y.T. Ma; X. Xie; Y.N. Yang; X.M. Li; Y.Y. Zheng
03/31/2014
Mental deficiency; Obesity; Prader-Willi syndrome; Prader-Willi-like phenotype

Prader-Willi syndrome (PWS) is caused by the lack of expression of genes located on paternal chromosome 15q11-q13. This lack of gene expression may be due to a deletion in this chromosomal segment, to maternal uniparental disomy of chromosome 15, or to a defect in the imprinting center on 15q11-q13. PWS is characterized by hypotonia during the neonatal stage and in childhood, accompanied ... more

C.F. Rocha; C.L.A. Paiva
03/30/2015
Chinese; Metabolic syndrome; Obesity; Polymorphism; Type 2 diabetes

Metabolic syndrome (MetS) includes obesity, dyslipidemia, elevated blood pressure, and dysglycemia. Subjects with type 2 diabetes (T2D) exhibit features of MetS. The etiology of MetS is complex, involving both environmental and genetic factors. In this study, we examined the role of specific candidate genetic variants on the severity of MetS in T2D subjects. A total of 240 T2D subjects ... more

Y.L. Chen; D. Pei; Y.J. Hung; C.H. Lee; F.C. Hsiao; C.Z. Wu; J.D. Lin; C.H. Hsu; J.B. Chang; C.H. Hsieh
02/06/2015
FABP2; Meta-analysis; Metabolic syndrome; Obesity; Type 2 diabetes mellitus

Previous studies have reported associations between the functional FABP2 Ala54Thr (rs1799883) polymorphism and type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome in different populations with conflicting results. We investigated the association between the FABP2 Ala54Thr polymorphism and T2DM (235 cases, 431 controls), obesity (377 cases, 431 controls), and ... more

Y. Liu; G. Wu; L. Han; K. Zhao; Y. Qu; A. Xu; Q. Huang
01/26/2015
Insulin resistance; Meta-analysis; Obesity; Polymorphism; TNF-α

Tumor necrosis factor-α (TNF-α) promoter polymorphisms has been reported to be associated with obesity and insulin resistance and gained widespread attention. However, results obtained so far are quite conf‍‍licting. We therefore performed a meta-analysis to address this issue, basing on 17 studies from electronic databases (MEDLINE and EMBASE). No evidence of ... more

H.G. Wang; J. Yang; H. Han; F. Xu; Y. Bian; H. Zhang; J.L. Wang

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