Research Article

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06/22/2010
Association study; Major depressive disorder; Rs6311; Serotonin 2A receptor; Single nucleotide polymorphism; Thai population

Several lines of evidence suggest a molecular role of -1438A/G single nucleotide polymorphism in the 5-HTR2A gene promoter (rs6311) in regulating the expression of this gene, making rs6311 polymorphism a promising candidate for an association study. We looked for a possible association between rs6311 polymorphism and major depressive disorder (MDD) in a northeastern Thai ... more

T. Tencomnao; V. Thongrakard; W. Phuchana; T. Sritharathikhun; S. Suttirat
03/30/2010
Association study; DAT1; Major depressive disorder; rs40184; Single nucleotide polymorphism; Thai population

Several lines of evidence suggest that the dopaminergic system is involved in the pathophysiology of major depressive disorder (MDD). Since the dopamine transporter (DAT1, also known as SLC6A3), mediates the active reuptake of dopamine from the synapses and thereby plays a vital role in the regulation of dopaminergic neurotransmission, we looked for a possible association between the C/T ... more

N. Pattarachotanant; T. Sritharathikhun; S. Suttirat; T. Tencomnao
02/02/2010
Association study; Psoriasis; Psoriasis subtype; Serotonin 2A receptor; Single nucleotide polymorphism; Thai population

Expression of serotonin 2A receptor (5-HTR2A) is known to increase in psoriasis, a chronic inflammatory skin disease. We investigated a possible association between the -1438A/G single nucleotide polymorphism (rs6311) in the promoter region of 5-HTR2A gene and psoriasis in a Thai population. One hundred and twelve psoriatic patients and 151 unrelated healthy controls ... more

C. Ronpirin; T. Tencomnao; J. Wongpiyabovorn
01/12/2010
Association study; CYP27B1; EDN1; Genetic polymorphisms; GSTP1; Sarcoidosis

Sarcoidosis is a chronic inflammatory disease, characterized by granulomatous inflammation, prominently involving the respiratory system. The etiology of this disease has not yet been elucidated and the contribution of genetic is not yet completely understood. We searched for novel candidate genes, utilizing a system biology approach, based on data from published transcriptional, ... more

A. Maver; I. Medica; B. Salobir; M. Tercelj; B. Peterlin
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Association study; Meta-analysis; Type 2 diabetes; UCP2

Uncoupling protein 2 (UCP2) is a mitochondrial transporter protein and can affect the function of β-cells. We investigated a possible association between functional UCP2 -866G/A and Ala55Val polymorphisms and type 2 diabetes in 715 Hubei Han Chinese. No significant association was found, either for the -866G/A polymorphism (allele, P = 0.254; genotype, P = 0.508) or for the ... more

L.J. Qin; J. Wen; Y.L. Qu; Q.Y. Huang
08/06/2012
Association study; Body mass index; CYP17; Obesity

The cytochrome P450c17α gene (CYP17) encodes a key biosynthesis enzyme of estrogen, which is critical in regulating adipogenesis and adipocyte development in humans. We therefore hypothesized that CYP17 is a candidate gene for predicting obesity. In order to test this hypothesis, we performed a family-based association test to investigate the relationship between the ... more

H. Yan; Y. Guo; T.L. Yang; L.J. Zhao; H.W. Deng
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Association study; Brazilian population; Chronic myeloid leukemia; Genetic polymorphisms; Hardy-Weinberg equilibrium

Chronic myeloid leukemia is a hematopoietic stem cell disorder that causes uncontrolled proliferation of white blood cells. Although the clinical and biological aspects are well documented, little is known about individual susceptibility to this disease. We conducted a case-control study analyzing the prevalence of the polymorphisms MTHFR C677T, MTHFR A1298C, del{ ... more

G.S. Lordelo; A.L. Miranda-Vilela; A.K. Akimoto; P.C.Z. Alves; C.O. Hiragi; A. Nonino; M.B. Daldegan; M.N. Klautau-Guimarães; C.K. Grisolia
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Association study; Pancreatic cancer; SNPs; TRIB1 gene

Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues that form the pancreas. To investigate whether the tribbles homolog 1 (Drosophila) gene (TRIB1) is associated with pancreatic cancer in the Chinese Han population, we conducted this case-control study and genotyped 3 single nucleotide polymorphisms (rs2980879, rs2980874, and ... more

X.X. Lu; J.J. Hu; Y. Fang; Z.T. Wang; J.J. Xie; Q. Zhan; X.X. Deng; H. Chen; J.B. Jin; C.H. Peng; J. Liu; H.W. Li; B.Y. Shen
05/16/2014
Association study; BRCA2; Cardiovascular disease; HapMap; Saudi Arabian population; Single nucleotide polymorphism

Abnormalities in the breast cancer tumor suppressor genes (BRCA1 and BRCA2) are associated with breast and ovarian cancer. Recently, two single nucleotide polymorphisms (SNPs; rs11571836 and rs1799943) were identified, both located in untranslated regions of chromosome 13, associated with cardiovascular disease (CVD) in a multi-ethnic population. We examined the ... more

M. Alanazi; N.P. Reddy; J.P. Shaik; S.A. Ajaj; A.A.A. Jafari; H. Saeed; Z. Khan; A.P. Khan
04/08/2014
Association study; Inflammatory bowel diseases; Meta-analysis; Polymorphism; Vitamin D receptor

The gene encoding vitamin D receptor (VDR) is recognized as a promising candidate for indicating the development of inflammatory bowel disease (IBD). Four genetic polymorphisms (ApaI, BsmI, FokI, TaqI) in VDR have been widely evaluated to determine their association with IBD, and the results of these evaluations are often inconsistent. ... more

L. Wang; Z.T. Wang; J.J. Hu; R. Fan; J. Zhou; J. Zhong

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