Research Article

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02/06/2015
Apoptosis; Curcumin; Invasion; Melanoma; Migration; Proliferation

Malignant melanoma is a melanocytic tumor with a high potential of invasion and metastasis. Curcumin is extracted from Curcuma longa L.; curcumin has anti-tumor efficacy in multiple systemic malignancies. Here, we investigated the effect of curcumin on A375 human melanoma cells. A375 cells were cultivated, passaged, and treated with different concentrations of curcumin. We ... more

Y.P. Zhang; Y.Q. Li; Y.T. Lv; J.M. Wang
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Apoptosis; Apoptotic pathway; Bombyx batryticatus; Cytotoxicity; Hela cells

Anticancer activity of Bombyx batryticatus ethanol extract (BBE) against HeLa cells was studied using cell viability, DNA fragmentation, real-time polymerase chain reaction, and Western blot analyses. The BBE inhibited the growth and induced apoptosis of HeLa cells. The MTT assay indicated that the BBE induced cytotoxicity in HeLa cells in a time- and concentration-dependent ... more

W.P. Wu; J. Cao; J.Y. Wu; H. Chen; D. Wang
01/15/2015
Apoptosis; BPH-1 cells; Cell cycle; Croton membranaceus; Proliferation

Croton membranaceus aqueous root extract (CMARE) is among the widely used phytotherapeutics in Ghana for the management of benign prostatic hyperplasia (BPH) and prostate cancer. However, the mechanism of action of CMARE remains to be elucidated. This study aimed to establish whether apoptosis is involved in the antiproliferative effect of CMARE on human BPH-1 cells. We ... more

D.K. Afriyie; G.A. Asare; K. Bugyei; J. Lin; J. Peng; Z. Hong
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Bladder cancer; CCR2-V64I; Chemokines; MCP-1 A-2518G; Polymorphism

Chemokines are potent proinflammatory cytokines that are implicated in numerous inflammatory diseases. Proinflammatory gene polymorphisms lead to variations in the production and concentration of inflammatory proteins. We investigated a possible association between polymorphisms in chemokine and chemokine receptor genes (MCP-1 A-2518G and CCR2-V64I) and bladder cancer risk. Genotypes were ... more

K.F. Narter; B. Agachan; S. Sozen; Z.B. Cincin; T. Isbir
05/06/2013
Bladder cancer; KEGG pathway; T1-T2; Ta-T1; Tumor grades

Bladder cancer is a highly heterogeneous neoplasm. We examined the gene expression profile in 3 bladder cancer stages (Ta, T1, T2) using expression microarray analysis of 40 bladder tumors. Differentially expressed genes were found by the t-test, with <0.005 as the significance threshold. KEGG pathway-enrichment analysis was used to study the signaling pathways of the genes. ... more

Z.Q. Fang; W.D. Zang; R. Chen; B.W. Ye; X.W. Wang; S.H. Yi; W. Chen; F. He; G. Ye
04/02/2013
Bladder cancer; Recurrence; Survivin; Vascular endothelial growth factor

Survivin and vascular endothelial growth factor (VEGF) are newly discovered tumor markers closely correlated with bladder cancer. We analyzed the expression of survivin and VEGF in paraffin-embedded tumor tissues from 78 patients with bladder transitional cell carcinoma (BTCC) using an immunohistochemistry method. Normal bladder mucosae from 10 non-BTCC cases were also included as a ... more

Y.W. Sun; Q. Xuan; Q.A. Shu; S.S. Wu; H. Chen; J. Xiao; P. Xiang; Y.P. Zhu; F.L. Wang; S.T. Zhao
09/26/2012
Bladder cancer; Genetic susceptibility; hOGG1; Meta-analysis; Polymorphism

The functional polymorphism Ser326Cys (rs1052133) in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in bladder cancer risk. However, reports of this association between the Ser326Cys polymorphism and bladder cancer risk are conflicting. In order to help clarify this relationship, we made a meta-analysis of seven case-control studies, summing 2521 cases ... more

D.Y. Zhong; H.Y. Chu; M.L. Wang; L. Ma; D.N. Shi; Z.D. Zhang
11/28/2014
Bladder cancer; Gene polymorphism; Meta-analysis; XRCC1 Arg399Gln

We examined whether the X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism is a risk factor for bladder cancer by conducting a meta-analysis. We searched the Pubmed and Embase databases for study retrieval. This meta-analysis examined 16 case-control studies, including 892 prostate cancer cases and 1020 healthy controls. Meta-analysis results based on these studies ... more

L.M. Dong; X.Y. Zhang; H. Teng; M.S. Li; P. Wang
07/25/2014
Bladder cancer; Meta-analysis; PSCA; rs2294008 (C>T) polymorphism

Several published articles have evaluated the association between the prostate stem cell antigen (PSCA) rs2294008 (C>T) polymorphism and bladder cancer risk, but the results remain inconclusive. In order to derive a more precise estimation of the association, we performed a meta-analysis of four case-control studies that included 9617 cases and 16,323 controls. Odds ratios (ORs) and 95 ... more

Y. Zhao; Z.L. Gui; S. Liao; F. Gao; Y.Z. Ge; R.P. Jia
04/30/2014
Bladder cancer; Control mechanism; Genes; Module network

Bladder cancer is a common cancer worldwide and its incidence continues to increase. There are approximately 261,000 cases of bladder cancer resulting in 115,000 deaths annually. This study aimed to integrate bladder cancer genome copy number variation information and bladder cancer gene transcription level expression data to construct a causal-target module network of the range of ... more

J.M. Wang; Y.Q. Wang; Z.L. Gao; J.T. Wu; B.K. Shi; C.C. Yu

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