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Related GMR Articles

11/18/2013
Chemokine; Gene; Inflammation; OSCC; Polymorphism

We aimed to evaluate the effect of genetic variants of the chemokine C-C motif receptor (CCR5) in the pathogenesis of oral squamous cell carcinoma (OSCC). A total of 127 patients diagnosed with OSCC and 104 healthy individuals were included in the study. The polymorphisms CCR5 59029 and CCR5-delta32 were assessed with the polymerase chain reaction-restricted fragment length polymorphism ( ... more

C.R. Tanyel; Z.B. Cincin; B. Gokcen-Rohlig; K. Bektas-Kayhan; M. Unur; B. Cakmakoglu
03/13/2013
Cattle; Hanwoo; Phospholipid transfer protein; Polymorphism; SNP

Phospholipid transfer protein (PLTP) regulates high-density lipoprotein metabolism. The gene encoding PLTP is located on bovine chromosome 13. The objective of this study was to identify single nucleotide polymorphisms (SNPs) in the Hanwoo (Bos taurus coreanae) PLTP gene to detect novel mutations affecting economically important traits. Five SNPs were identified in the coding ... more

J. Seong; J.D. Oh; H.K. Lee; G.J. Jeon; H.S. Kong
08/29/2012
ANAPC13; Body measurement traits; Cattle; PCR-SSCP; Polymorphism

Body measurement traits, influenced by genes and environmental factors, play numerous important roles in the value assessment of productivity and economy. There has been some indication that ANAPC13 influences adult height. We used PCR-SSCP and DNA sequencing technology to identify polymorphisms in the ANAPC13 gene. A polymorphism in intron 1 (A > G at base 17) was identified and an ... more

B.J. Jiang; X.L. Zhan; C.Z. Fu; H.B. Wang; G. Cheng; L.S. Zan
11/14/2014
Cattle; Haplotype; Polymorphism; Short tandem repeat; Y-chromosome

The aim of this study is to use Y-chromosome gene polymorphism method to investigate regional differences in genetic variation and population evolution history of the Chinese native cattle breeds. Six Y-chromosome short tandem repeat (Y-STR) loci (UMN0929, UMN0108, UMN0920, INRA124, UMN2404, and UMN0103) were analyzed using 1016 healthy ... more

Y.P. Xin; L.S. Zan; Y.F. Liu; W.Q. Tian; H.B. Wang; G. Cheng; A.N. Li; W.C. Yang
11/07/2014
Bos taurus indicus; Cattle; InDel; Polymorphism; Traceback

Brazil is a major producer and exporter of beef, with a herd of approximately 210 million animals. For the meat industry, a reliable animal traceback from its origin to the consumer market is paramount. Of all available identification systems, DNA is the only one that survives the slaughterhouse and reaches the dish of the consumer. DNA polymorphisms are already used for cattle traceback ... more

M. Groenner-Penna; E.F.D. Croce; C.G. Pimenta; H.M.S. Bicalho; S.D.J. Pena
02/20/2014
Coronary artery disease; Endothelial lipase; Gene; Polymorphism

A growing body of evidence suggests that the 584C/T polymorphism in the endothelial lipase (EL) gene contributes to the process of coronary artery disease (CAD). The present study aimed to reveal the potential relationship between the EL 584C/T gene polymorphism and early-onset CAD, CAD severity, and lipid levels in a Chinese Han population. Participants comprised 135 early-onset CAD ... more

G.J. Cai; G.P. He; Z.Y. Huang; C.P. Qi
01/17/2014
COX-1; Gene; Polymorphism

Variation in the gene encoding cyclooxygenase-1 (COX-1) is involved in the process of aspirin resistance. This study investigated the genetic variations in the COX-1 gene. The 4 coding regions of the human COX-1 gene in 90 pediatric patients (median age of 6.5 months, 55% males) with cardiovascular anomalies were screened using DNA sequencing. Twenty coding-region variants causing amino ... more

I. Coskun; Y. Colkesen; F. Ayik; A. Berdeli; Y. Atay
06/01/2015
Arg389Gly; Gene; Heart failure; Meta-analysis; Polymorphism; β1 adrenergic receptor

Numerous studies have evaluated the association between Arg389Gly polymorphism in the β1 adrenergic receptor gene and heart failure risk. However, the specific association is still controversial. We performed a meta-analysis of all case-control studies that evaluated the association between Arg389Gly polymorphism and heart failure in humans. Studies were identified in the PubMed, Embase, ... more

S.T. Ma; W. Zhao; B. Liu; R.Y. Jia; C.J. Zhao; L.Q. Cui
05/22/2015
Gene; Mild cognitive impairment; Polymorphism; Thyroid hormone; Type 2 deiodinase; Uygur

We investigated type II deiodinase (DIO2) polymorphisms and serum thyroid hormone levels in subjects with mild cognitive impairment (MCI) in a Uygur population. We studied the DIO2 Thr92Ala (rs225014) and ORFa-Gly3Asp (rs12885300) polymorphisms of 129 unrelated MCI cases and 131 matched controls. All subjects were genotyped using SNaPshot SNP genotyping assays. Serum ... more

M. Luo; X.H. Zhou; T. Zou; K. Keyim; L.M. Dong
05/22/2015
Carcass composition trait; Cattle; Growth trait; Meat quality trait; Polymorphism; Thyroglobulin gene

Thyroid hormones play an important role in regulating metabolism and can affect metabolism-related traits such as fat deposition. The thyroglobulin (TG) gene produces the precursor of thyroid hormones and has been proposed as a candidate gene for a quantitative trait locus with an effect on fat deposition. In this study, we identified 4 novel single nucleotide polymorphisms (SNPs ... more

L.P. Zhang; Q.F. Gan; G.Y. Hou; H.J. Gao; J.Y. Li; S.Z. Xu

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