Research Article

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12/08/2011
Colorectal cancer; Meta-analysis; Polymorphism; VEGF

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in a number of pathologic processes, including angiogenesis, tumor growth and metastasis. Polymorphisms of the VEGF gene have been associated with susceptibility to colorectal cancer (CRC). However, the specific association still remains controversial. We made a meta-analysis of the association ... more

L.P. Zhou; H. Luan; X.H. Dong; G.J. Jin; D.L. Man; H. Shang
12/08/2011
Endometrial cancer; Meta-analysis; p53 gene; Polymorphism; susceptibility

Polymorphisms of the p53 gene have been associated with susceptibility to endometrial cancer. However, whether there is a specific association is still controversial. We investigated a possible association between p53 codon 72 polymorphism and endometrial cancer risk by conducting a meta-analysis. Publications addressing this association were selected from the Pubmed, Embase and CBM ... more

Y. Gu; X. Zhou; S.L. Zhang
12/08/2011
Head and neck cancer; Meta-analysis; Polymorphism; XPD

Several studies have investigated the association between Lys751Gln polymorphism in the xeroderma pigmentosum group D (XPD) gene and risk of head and neck cancer; however, the published results are conflicting. We conducted a meta-analysis that comprised 15 published case-control studies examining the association of head and neck cancer risk with XPD Lys751Gln ... more

H. Yuan; Y.M. Niu; R.X. Wang; H.Z. Li; N. Chen
12/15/2011
Human leukocyte antigen; Meta-analysis; Polymorphism; Psoriasis; Risk

Numerous studies have evaluated the association between human leukocyte antigen (HLA) Cw*0602 polymorphism and psoriasis risk. However, the results have been inconsistent. We made a meta-analysis of the association between HLA-Cw*0602 polymorphism and psoriasis risk. Eighteen studies were retrieved, reporting a total of 3419 psoriasis patients and 3297 healthy controls. The associations ... more

D. Wu; Y. Wu; J.L. Liu; B. Wang; X.D. Zhang
10/13/2011
Lung cancer risk; Meta-analysis; p21; Polymorphism; Ser31Arg

The cyclin-dependent kinase inhibitor 1A (also known as p21) is thought to be involved in tumor development by mediating cell cycle arrest through the inhibition of cyclin/CDK activity. To explore the relationship of Ser31Arg polymorphism in the p21 gene with the risk of developing lung cancer, we performed an overall and stratified meta-analysis based on ethnicity, lung ... more

G. Lin; F. Fang; X.J. Yu; L. Yu
09/21/2010
Endothelial nitric oxide synthase; Essential hypertension; Meta-analysis; Polymorphism

We examined the effect of polymorphisms in the endothelial nitric oxide synthase gene on the risk for essential hypertension in a Han Chinese population through a meta-analysis of data from 15 studies. Associations between increased risk for essential hypertension and 4b/a were obtained in a dominant model and allele contrast (aa + ab vs bb: odds ratio (OR)FE = 1.26, ... more

H.G. Wang; J.L. Wang; P. Chang; F.L. Cao; X.C. Liu; Y.B. Ma; G.X. Zhai; H.Q. Gao
04/06/2010
DNA repair; Endometriosis; Polymorphism; XRCC3 Thr/Thr

Several polymorphisms in the DNA repair gene are thought to have significant effects on cancer risk. We investigated the association of polymorphisms in the DNA repair genes XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys with endometriosis risk. Genotypes were determined by PCR-RFLP assays in 52 patients with endometriosis and 101 age- ... more

R. Attar; C. Cacina; S. Sozen; E. Attar; B. Agachan
12/19/2013
Cerebrovascular disease; Meta-analysis; Methylenetetrahydrofolate reductase; Polymorphism; Stroke

Several independent studies have reported the role of the methylenetetrahydrofolate reductase gene (MTHFR) A1298C polymorphism in strokes, but the results are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed in the present study. In this meta-analysis, a total of 13 studies, including 1974 cases and 2660 controls, were selected ... more

Q.Q. Lv; J. Lu; W. Wu; H. Sun; J.S. Zhang
04/26/2013
CCND1 gene; Esophageal cancer; Genetic association; Meta-analysis; Polymorphism

The association between the Cyclin D1 gene (CCND1) G870A polymorphism and esophageal cancer has been widely evaluated, with conflicting results. As meta-analysis is a reliable approach to resolving discrepancies, we aimed to evaluate this association. Data were available from 9 study populations incorporating 1898 cases and 3046 controls. Overall, the allelic/genotypic ... more

W. Cai; Z.T. Wang; J. Zhong; Y. Zhang
12/10/2013
COMT; Endometrial cancer; Meta-analysis; Polymorphism

Catechol-O-methyltransferase (COMT) is a critical enzyme to detoxify the carcinogenic catechol estrogen and the Val158Met polymorphism of COMT could influence its enzymatic activity. Recent epidemiological studies have investigated the correlation of COMT Val158Met polymorphism with endometrial cancer risk; however, the results are inconsistent. To better evaluate the role of ... more

G. Lin; J. Zhao; J. Wu; A. O; W.H. Zhang; Y. Zhang; L. Yu

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