Research Article

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Adiponectin; Adrenergic receptor; Cardiometabolic risk factor; Obesity; Polymorphism

We determined whether ADRβ3 polymorphism is associated with obesity-related traits in 140 obese patients. Molecular analysis was performed by PCR and RFLP. Individuals carrying the Arg64 allele had a lower waist-to-hip ratio, higher adiponectin and high-density lipoprotein cholesterol levels, and a tendency towards lower blood pressure. In contrast, Trp64/Trp64 carriers ... more

V.A. Genelhu; E.A. Francischetti; S.F.P. Duarte; B.M.J. Celoria; R.C. Oliveira; P.H. Cabello; M.M.G. Pimentel
12/19/2013
Angiotensin-I coverting enzyme; Hyperlipidemia; Multifactorial disease; Obesity; Smoking

Coronary artery disease (CAD) is a multifactorial disease influenced by genetic and environmental factors. Major risk factors of CAD are hypertension, hyperlipidemia, smoking, family history and obesity. Also polymorphisms in the angiotensin-I converting enzyme (ACE) gene can associate with CAD. The relationship between ACE polymorphisms and other risk factors is not well ... more

A.I. Güney; D. Ergec; D. Kırac; H. Ozturhan; M. Caner; G. Koc; C. Kaspar; K. Ulucan; M. Agirbasli
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-308G>A; Breast cancer; Mexican population; Obesity; Risk factor; Tumor necrosis factor alpha

The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes of 294 healthy Mexican women with ... more

G. Flores-Ramos; E. De Dios; A.M. Puebla-Pérez; L.E. Figuera-Villanueva; A. Ramos-Silva; R. Ramírez-Patiño; J.I. Delgado-Saucedo; E. Salas-González; G.M. Zúñiga-González; A. Alonzo-Rojo; I. Gutiérrez-Hurtado; M.P. Gallegos-Arreola
09/27/2013
Exercise; Genetic risk factor; Nutritional intervention; Obesity

We evaluated the response of individuals with metabolic syndrome to lifestyle modification intervention and examined the influence of the 48867A>C (Asp358Ala) IL6R (rs2228145) polymorphism on this response. Participants were randomly divided into two groups: NI, nutritional intervention; NIE, nutritional intervention and exercise practice. Intervention lasted three months and ... more

V.R.A. Vargas; S.L. Bonatto; F.E. Macagnan; A.M.P. Feoli; C.S. Alho; N.D.V. Santos; V.M. Schmitt
09/03/2012
Developmental delay; GPC5; Obesity; Overgrowth; SH2B1

Chromosome microarray analysis of patients with developmental delay has provided evidence of small deletions or duplications associated with this clinical phenotype. In this context, a 7.1- to 8.7-Mb interstitial deletion of chromosome 16 is well documented, but within this interval a rare 200-kb deletion has recently been defined that appears to be associated with obesity, or ... more

A.M. George; J. Taylor; D.R. Love
08/31/2012
Cell cycle; Coexpression network; Obesity; Pathway enrichment analysis

The aim of this study was to identify related genes and the underlying molecular mechanisms in obese patients who show a series of clinical and metabolic abnormalities known as metabolic syndrome. We identified expression profiles through a coexpression network. In addition, a similarity matrix and expression modules were constructed based on domain and pathway enrichment analysis. The ... more

J.F. Zhang; G.Y. Yao; Y.H. Wu
08/06/2012
Association study; Body mass index; CYP17; Obesity

The cytochrome P450c17α gene (CYP17) encodes a key biosynthesis enzyme of estrogen, which is critical in regulating adipogenesis and adipocyte development in humans. We therefore hypothesized that CYP17 is a candidate gene for predicting obesity. In order to test this hypothesis, we performed a family-based association test to investigate the relationship between the ... more

H. Yan; Y. Guo; T.L. Yang; L.J. Zhao; H.W. Deng
05/16/2014
Body mass index; Middle-aged; Obesity; Overweight; Prevalence; Risk factors

In this study, a survey was conducted through questionnaire distribution and physical examinations were performed in 10,150 residents that were over 40 years old in Luzhou city. Respondents were selected by the multi-stage sampling method. The mean body mass index (BMI) of the sample population was 23.9 ± 3.3 kg/m2. Among men, BMI showed a negative relationship with increasing ... more

J. Zeng; Q. Wan; X. Bai; X.Z. Li; F. Liu; C. Li; X.Y. Liu; Y. Wang
10/20/2014
ADRB2 gene polymorphisms; Body mass index; Obesity; Obstructive sleep apnea syndrome; Restriction fragment length polymorphism; Turkish population

We determined the distribution of the Arg16Gly and Gln27Glu polymorphisms of the beta-2 adrenergic receptor gene (ADRB2) in patients with obstructive sleep apnea syndrome as well as a control group in Northeastern Turkey. A total of 52 patients diagnosed with obstructive sleep apnea in a sleep laboratory and 78 control subjects were examined. Peripheral blood samples were taken ... more

İ. Gök; İ. Çelebi; N. Hüseyinoğlu; C. Özic
08/28/2014
Diabetes; Lipase; Obesity

The aim of this study was to detect the serum adipose triglyceride lipase (ATGL) levels in obesity and newly diagnosed type 2 diabetes patients, and to explore the association between ATGL with glucose and lipid metabolism. We enrolled 66 patients with type 2 diabetes and 48 patients with normal glucose regulation, who were divided into an overweight or obese subgroup and a normal weight ... more

L. Yang; S.J. Chen; G.Y. Yuan; L.B. Zhou; D. Wang; X.Z. Wang; J.J. Chen

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