Research Article

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We explored a possible correlation of genetic instability and CpG methylation in the 5'-flanking region of the PAI-1 gene with clinicopathologic features of gastric cancer in Chinese patients and looked for molecular markers for diagnosing gastric tumor development. Microsatellite instability and loss of heterozygosity of the PAI-1 gene locus D7S515, D7S471 and pai-1 ... more

J. Liu; X. Li; N. Yu; Y.Q. Yang; X. Li; Z.Y. Ye; J.C. Li
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Buccal cells; Down syndrome; genomic instability; Micronucleus

Down syndrome has been linked to premature aging and genomic instability. We examined the frequency of micronucleus (MN) and binucleated cells in the oral mucosa of Down syndrome patients and healthy controls matched by age and gender, addressing the effect of age and family income. Down syndrome individuals had an increased number of MN (14.30 ± 9.35 vs 4.03 ± 1.71; P 0.001) ... more

F.L.S. Ferreira; D. Prá; M.G. Martino-Roth; G.L. Garcias
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Apoptosis; DNA damage; genomic instability; Inflammation; Isocyanates; Lung cancer

Lungs comprise the primary organ exposed to environmental toxic chemicals, resulting in diverse respiratory ailments and other disorders, including carcinogenesis. Carcinogenesis is a multi-stage phenomenon, which involves a series of genetic alterations that begin with genomic instability provoked by certain factors such as inflammation and DNA damage and end with the development of cancer. ... more

P.K. Mishra; A. Bhargava; G.V. Raghuram; S. Gupta; S. Tiwari; R. Upadhyaya; S.K. Jain; K.K. Maudar
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gene fusions; genomic instability; healthy individuals; Leukemia; lymphoma

Hematopoietic neoplasias are characterized by recurrent chromosomal aberrations that result in the formation of gene fusions and the subsequent expression of chimeric proteins with unique properties. However, in recent years, different lymphoma/leukemia-associated rearrangements, such as BCR/ABL, IGH/BCL2, ETV6/RUNX1 and MLL duplications, have been detected in healthy individuals. The presence ... more

M.S. Brassesco
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This study searched a rare and aggressive type of cancer in dogs and humans, the breast carcinosarcoma. Both clinical and pathological traits of mammary carcinosarcomas in dogs are similar to humans, such as infrequent occurrence, fast tumor growth, and unfavorable prognosis when compared to carcinomas. Other possible alterations include chromosomal abnormalities that can be useful for the ... more

C.S.D. Morais; P.R.A.M. Affonso; J.A. Bitencourt; A.A. Wenceslau
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Droughts; environment; genomic instability; Hybridization, Genetic; Models, Genetic; Plant breeding; Quantitative Trait, Heritable; Stress, Physiological; Zea mays

In several crops, the water deficit is perhaps the main limiting factor in the search for high yields. The objective of this study was to evaluate the phenotypic stability of maize hybrids in environments with and without water restriction using the analytical factor (AF) approach. We evaluated 171 maize hybrids in 14 environments, divided into environments with (A1, A2, A3, A4, A5, A6, and A7 ... more

A.O. Santos; J.J. Nuvunga; C.P. Silva; L.P.M. Pires; R.G. Von Pinho; L.J.M. Guimarães; M. Balestre
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Brazil; Edible Grain; environment; genomic instability; Genotype; Glycine max; Plant breeding; Quantitative Trait, Heritable; Selection, Genetic; Selective breeding

Biplot analysis has often been used to recommend genotypes from different crops in the presence of the genotype x environment interaction (GxE). The objective of this study was to verify the association between the AMMI and GGE biplot methods and to select soybean genotypes that simultaneously meet high grain yield and stability to the environments belonging to the Edaphoclimatic Region 402, ... more

E.U.Ramos Junior; R.L. Brogin; V.P.C. Godinho; F.J.E. Botelho; F.D. Tardin; P.E. Teodoro
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Gene-Environment Interaction; Genetic variation; genomic instability; Glycine max; Hypocotyl; Models, Genetic; Plant breeding; Plant Leaves; Quantitative Trait, Heritable; Selective breeding

In order to obtain the certificate of cultivar protection, it is necessary to prove its distinctiveness, homogeneity, and stability. Currently, there are 37 descriptors for differentiating soybeans cultivars. However, they are still not enough and, as a result, it is necessary to create, identify, and evaluate new descriptors. This study was aimed at evaluating the genotypic and environment ... more

M.V.A. Chaves; N.S. Silva; R.H.O. Silva; G.L. Jorge; I.C. Silveira; L.A. Medeiros; R.L. Hamawaki; O.T. Hamawaki; A.P.O. Nogueira; C.D.L. Hamawaki
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Cisplatin; Cisplatin-induced keratin 10; Multi-Drug Resistance; Ovarian cancer; Phosphatase and tensin homolog

Drug resistance is a major cause of treatment failure in ovarian cancer patients, and novel therapeutic strategies are urgently needed. Overexpression of phosphatase and tensin homolog (PTEN) has been shown to preserve the cisplatin-resistance of ovarian cancer cells, while cisplatin-induced keratin 10 (KRT10) overexpression mediates the resistance-reversing effect of PTEN. However, ... more

H. Wu; K. Wang; W. Liu; Q. Hao
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The aim of the present study was to investigate the anti-ovarian cancer effect of the inhibitor of signal transducer and activator of transcription 3 (STAT3), WP1066. Western blot was used to detect the phosphorylation of STAT3 in ovarian cancer cell line SKOV3 and cisplatin-resistant ovarian cancer cell line SKOV3/DDP. MTT and colony-forming assays were performed to evaluate the ... more

Y.J. Tang; Z.L. Sun; W.G. Wu; J. Xing; Y.F. He; D.M. Xin; P. Han