Research Article

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12/06/2017
Gastric cancer; Microarray; MicroRNA; Oncomirs; Precision Medicine; Systems biology; Tumor suppressors
MicroRNAs (miRNAs) are non-coding small RNA molecules that regulate the differential expression of genes. The expression of miRNAs is dysregulated in various types of cancers,
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09/09/2015
Abnormal chromosome; Genetic diseases; Systematic review

We evaluated the system accuracy of noninvasive prenatal diagnosis for abnormal chromosome genetic diseases using cell-free fetal DNA in maternal plasma. Previous studies were searched in the MEDLINE database using the following keywords: “prenatal” and “aneuploidy” and “noninvasive or non-invasive” and “maternal”. Identified studies were filtered using a QUADAS instrument. Four studies ... more

H. Yang; H.B. Xu; T.T. Liu; X.L. He
12/14/2015
Case-control study; COMT; Meta-analysis; Ovarian cancer; Single nucleotide polymorphism; Systematic review

The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ovid, EBSCO, PubMed, CNKI, CBMDISC, VIP, ... more

W. Pan; H. Liao
02/01/2023
Meta-analysis; Neurodegenerative diseases; Polymorphisms; Systematic review; VEGF-A

Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are degenerative scleroses with unclear etiology. Vascular endothelial growth factor A (VEGF-A) is a growth factor that plays multiple roles in the central nervous system.  Previous studies indicated a potential association between polymorphisms in this gene and the susceptibility of ALS and ... more

J.O. Costa; C.C.P. Costa; N.S. Lima; K.F. Santos; A.A.S. Reis; R.S. Santos
02/01/2023
Meta-analysis; Neurodegenerative diseases; One-carbon metabolism; Polymorphisms; Systematic review

The folate cycle is a biochemical pathway that plays an important role in the development and maintenance of the nervous system. Biocompounds synthesized in this cycle must be carefully regulated, since the accumulation of some substances can be neurotoxic and increase susceptibility to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and ... more

J.V.A. Neves; N.S. Lima; C.C.P. Costa; K.F. Santos; A.A.S. Reis; R.S. Santos
07/13/2015
Bacteria; Biofilm; Interleukin 17; T helper 17 cells

We investigated the role of bacterial biofilms in stimulating T helper 17 (Th17) cells in infected organisms. The formation of bacterial biofilms isolated from clinical lavage fluid samples was measured. Th17 cells and interleukin 17 (IL-17) levels in the peripheral blood of healthy individuals, people infected by biofilm bacteria, people infected by non-biofilm bacteria, and in the lavage ... more

G.Q. Wang; L. Wang; H.L. Zhang; Y.Q. Dong; Y.X. Yang
10/30/2015
Bacteria; Bioinformatics; Fungi; Laccase; Oomycetes; Plant pathogen

To date, research on laccases has mostly been focused on plant and fungal laccases and their current use in biotechnological applications. In contrast, little is known about laccases from plant pathogens, although recent rapid progress in whole genome sequencing of an increasing number of organisms has facilitated their identification and ascertainment of their origins. In this study, a ... more

B.Z. Feng; P.Q. Li; L. Fu; X.M. Yu
12/19/2016
Bacteria; Bacterial Proteins; Computational biology; Databases, Protein; Gene Ontology; Humans; Protein Interaction Mapping

Since the first assembled genomes, gene sequences alone have not been sufficient to understand complex metabolic processes involving several genes, each playing distinct roles. To identify their roles, a network of interactions, wherein each gene is a node, should be created. Edges connecting nodes are evidence of interaction, for instance, of gene products coexisting in the same cellular ... more

G.S. Oliveira; A.R. Santos
2/16/2017
Bacteria; DNA, Bacterial; DNA, Ribosomal; Endophytes; Gluconates; Phosphates; Phylogeny; Plant Leaves; Plant Roots; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Soil Microbiology; Zea mays

In the present study, we demonstrated the in vitro activity of endophytic phosphate-solubilizing bacteria (PSB). Fifty-five endophytic PSB that were isolated from sap, leaves, and roots of maize were tested for their ability to solubilize tricalcium phosphate and produce organic acid. Partial sequencing of the 16S rRNA-encoding gene showed that the isolates were from the genus Bacillus and ... more

C.S. de Abreu; J.E.F. Figueiredo; C.A. Oliveira; V.L.Dos Santos; E.A. Gomes; V.P. Ribeiro; B.A. Barros; U.G.P. Lana; I.E. Marriel
3/08/2017
Animals; Bacteria; Biodiversity; Cheese; China; Cultured Milk Products; DNA, Bacterial; Food Microbiology; Fungi; Milk; RNA, Ribosomal, 16S; RNA, Ribosomal, 18S; Sequence Analysis, DNA

Hurood cheese (HC) and Jueke (Jk) are 2 traditional fermented dairy products produced from raw milk (RM) in the Inner Mongolia region of China. They have a long history of production and consumption. The microbial compositions of RM, HC, and Jk vary greatly, and are influenced by their geographical origins and unique processing methods. In this study, 2 batches of RM, HC, and Jk samples were ... more

M.L. Gao; H.M. Hou; X.X. Teng; Y.L. Zhu; H.S. Hao; G.L. Zhang

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