Research Article

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12/01/2015
Colorectal cancer; Mexican population; Polymorphisms; RUNX3 gene

We analyzed a possible association between RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer (CRC). Genomic DNA samples were obtained from the peripheral blood of 176 Mexican patients with CRC at diagnosis and from 195 individuals that formed the control group. The polymorphisms were detected by polymerase chain reaction-restriction fragment ... more

S. Suárez-Villanueva; M.L. Ayala-Madrigal; J. Peregrina-Sandoval; N. Macias-Gomez; R. Ramírez-Ramírez; R. Muñiz-Mendoza; J.M. Moreno-Ortiz; M. Centeno-Flores; V. Maciel-Gutiérrez; E. Cabrales; M. Gutierrez-Angulo
07/17/2015
Hcy; Methylation; MTHFR; Pregnancy hypertension

We investigated the correlation between 5,10-methy­lenetetrahydrofolate reductase (MTHFR) gene methylation and pre-eclampsia, and its clinical significance, by comparing methylation in the MTHFR gene promoter of the placenta and peripheral venous blood in pre-eclampsia and normal gravidas. We enrolled 259 gravidas from the People’s Liberation Army 202nd Hospital, China, between ... more

J. Ge; J. Wang; F. Zhang; B. Diao; Z.F. Song; L.L. Shan; W. Wang; H.J. Cao; X.Q. Li
02/02/2015
Folate metabolism; Folic acid; Preterm birth; Single nucleotide polymorphism

We investigated the association between 12 single nucleotide polymorphisms (SNPs) in 11 genes involved in folate metabolic and preterm birth. A subset of SNPs selected from 11 genes/loci involved in the folic acid metabolism pathway were subjected to SNaPshot analysis in a case-control study. Twelve SNPs (CBS-C699T, DHFR-c594+59del19, GST01-C428T, MTHFD- ... more

B.J. Wang; M.J. Liu; Y. Wang; J.R. Dai; J.Y. Tao; S.N. Wang; N. Zhong; Y. Chen
04/07/2016
A1298C; C677T; Lung cancer; Meta-analysis; MTHFR; Polymorphisms

Results from previous studies on the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been conflicting. The aim of this meta-analysis was to clarify the effect of MTHFR polymorphisms on the risk of lung cancer. An electronic search of PubMed, EMBASE, the Cochrane library, and the China Knowledge Resource ... more

Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu; Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu; Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu
07/13/2015
Colorectal cancer; Epithelial cell adhesion molecule; Immunohistochemistry

We investigated the relationship between the expression of epithelial cell adhesion molecule (EpCAM) and the occurrence and development of colon cancer. Fifty colon cancer tissues and adjacent normal tissues were collected, while 40 normal intestinal mucosa tissues were collected as the blank group. EpCAM expression was detected by immunohistochemistry and the patients were followed-up to ... more

X.B. Chai; R.F. Song; F. Xu
12/22/2015
Biomarker; Colorectal cancer; Diagnostic marker; Meta-analysis; MicroRNA-29a

Previous studies have revealed that the expression level of microRNA-29a (miR-29a) was remarkably different in colorectal cancer (CRC) patients and healthy controls, indicating that miR-29a can be used as a diagnostic marker of CRC, but the results have been inconsistent. We conducted this meta-analysis to assess the diagnostic performance of blood-based miR-29a for CRC. We performed a ... more

M.L. Zhi; Z.J. Liu; X.Y. Yi; L.J. Zhang; Y.X. Bao
12/14/2015
BRAFV600E mutation; Colorectal cancer; Histopathological criteria; KRAS mutations

KRAS and BRAF mutations are well-recognized molecular alterations during colorectal carcinogenesis, but there is little agreement on their effect on tumor characteristics. Therefore, we aimed to evaluate the distribution of the most common KRAS and BRAF mutations in Greek patients with colorectal cancer and their possible associations with clinical ... more

M. Samara; K. Kapatou; M. Ioannou; Ε. Kostopoulou; R. Papamichali; C. Papandreou; A. Athanasiadis; G. Koukoulis
12/02/2015
Angiopoietin-2; Colorectal cancer; Diagnostic biomarker

We examined the expression of angiopoietin-2 in serum samples from patients diagnosed with colorectal cancer and healthy volunteers and investigated the feasibility of using angiopoietin-2 as a potential diagnostic colorectal cancer biomarker. Enzyme-linked immunosorbent assays were used to measure the levels of angiopoietin-2 in patients with colorectal cancer and healthy control subjects. ... more

Z.Q. Wang; X.L. Sun; H.L. Su; X.F. Liu; Y.J. Xuan; S.Q. Yu
12/02/2015
Colorectal cancer; Meta-analysis; Non-metastatic protein 23; Pathological characteristics; Prognosis

The current meta-analysis was performed to investigate the association between non-metastatic protein 23 (NM23) expression, tumor pathology, and disease prognosis in colorectal cancer (CRC) among Asians. English and Chinese language-based electronic databases (e.g., PubMed, EBSCO, Ovid, Springerlink, Wiley, Web of Science, Wanfang databases, China National Knowledge Infrastructure, VIP ... more

J.W. Fu; X.Q. Chu
11/23/2015
Adenocarcinoma; Colorectal cancer; GA733 family; RT-PCR

GA733-1/-2/-3 genes have been detected in various types of cancer, although their role has not been fully clarified. GA733-2 and GA733-1 have been correlated with lymph node metastases in laryngeal cancer and liver metastases, respectively. Only a few studies have elucidated the mechanisms regulating GA733-1/-2 expression and their effect on colorectal cancer. ... more

I. Mamaloudis; D. Zacharoulis; M. Samara; G. Papadopoulos; S. Samara; G. Koukoulis; C. Chatzitheofilou; P. Kollia

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