Research Article

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Curcumin has been widely used for the prevention and treatment of Alzheimer's disease (AD), but its mechanism is still not clear. Inhibitory factors of axonal regeneration have been shown to cause a series of pathophysiological changes in the early period of AD. In this study, the co-receptor (Nogo receptor; NgR) of three axonal growth-inhibitory proteins was examined, and effects of ... more

H.L. Yin; Y.L. Wang; J.F. Li; B. Han; X.X. Zhang; Y.T. Wang; S. Geng
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Curcumin; p38 MAPK; Ulcerative colitis

The aim of this study was to determine the therapeutic effect of curcumin on dextran sulfate sodium-induced ulcerative colitis (UC) and to explore the related mechanism. Sixty mice were randomly divided into 6 groups. A group was the normal control group; B group was the model group; C group was the 1.5 mg/kg dexamethasone group based on the B group; and D, E and F groups were 15, 30, ... more

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Apoptosis; Curcumin; Invasion; Melanoma; Migration; Proliferation

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Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell proliferation; Colorectal neoplasms; Curcumin; Drug Resistance, Neoplasm; Heat-shock proteins; HSP27 Heat-Shock Proteins; Humans; Inhibitor of Apoptosis Proteins; Molecular chaperones; Proto-Oncogene Proteins c-bcl-2; Survivin

Since there are no studies on the reversal of multidrug resistance by curcumin in the human colorectal cancer cell line HCT-8/5-FU, our aim was to search for highly efficient reversal agents and investigate the underlying mechanisms of this reversal. The cytotoxic effects of curcumin and 5-FU on HCT-8 and HCT-8/5-FU cells and the reversal effects of 5-FU in combination with curcumin on HCT-8/5 ... more

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Diabetic nephropathy; Gene polymorphism; Hypoxia-inducible factor-1α

We examined the correlation between gene polymorphisms in hypoxia-inducible factor-1α (HIF-1α) Pro582Ser and type 2 diabetic nephropathy (DN). A total of 244 subjects with type 2 diabetes were recruited. The 1285-bp locus polymorphism of HIF-1α exon was detected using polymerase chain reaction-restriction fragment length polymorphism. C/T single nucleotide polymorphisms were detected at ... more

Y.X. Bi; L. Yu; G.X. Jin
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CARS; Diabetic nephropathy; FERM3; SNP

Diabetic nephropathy is the leading cause of end-stage kidney disease in the world. Many single nucleotide polymorphisms (SNPs) have been associated with diabetic nephropathy. SNPs at the 4.1 protein ezrin, radixin, moesin domain 3 (FRMD3) and cysteinyl t-RNA synthetase (CARS) genes have a well-established relationship with diabetic nephropathy. However, this association ... more

S. Al-waheeb; M. Alwohhaib; A. Abdelghani; S. Al-Sharrah; E. Al-Shafey; A. Al-Sahow; N. Alyatama; A.A. Dashti; N. Hussain; S. Al-waheeb; M. Alwohhaib; A. Abdelghani; S. Al-Sharrah; E. Al-Shafey; A. Al-Sahow; N. Alyatama; A.A. Dashti; N. Hussain; S. Al-waheeb; M. Alwohhaib; A. Abdelghani; S. Al-Sharrah; E. Al-Shafey; A. Al-Sahow; N. Alyatama; A.A. Dashti; N. Hussain
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The angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism could influence predisposition for diabetic nephropathy (DN) by vascular modulation in the kidney, through a direct effect on cellular hypertrophy. However, studies on the association between this polymorphism and DN report conflicting results. To help determine if this association ... more

L.C. Silveira; E.G. da Silva; R.M. Azevedo; L.R.Bdos Anjos; R.F. Chagas; E.C. Alcântara; R.S. Santos; A.A.S. Reis