Research Article

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12/01/2015
Colorectal cancer; Mexican population; Polymorphisms; RUNX3 gene

We analyzed a possible association between RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer (CRC). Genomic DNA samples were obtained from the peripheral blood of 176 Mexican patients with CRC at diagnosis and from 195 individuals that formed the control group. The polymorphisms were detected by polymerase chain reaction-restriction fragment ... more

S. Suárez-Villanueva; M.L. Ayala-Madrigal; J. Peregrina-Sandoval; N. Macias-Gomez; R. Ramírez-Ramírez; R. Muñiz-Mendoza; J.M. Moreno-Ortiz; M. Centeno-Flores; V. Maciel-Gutiérrez; E. Cabrales; M. Gutierrez-Angulo
11/24/2015
Chronic myeloid leukemia; Complete molecular response; Imatinib; Major molecular response; Multidrug resistance gene; Polymorphisms

Our study aimed to investigate the association between multidrug resistance (MDR1) gene polymorphisms and the response to imatinib (IM) in chronic myeloid leukemia (CML). An electronic databases in PubMed, Cochrane Library, Wanfang, China National Knowledge Infrastructure, and VIP were searched using combinations of keywords relating to MDR1 polymorphisms and the response to ... more

J.L. Wang; H.J. Liu; F. Li; W.Y. Yang; J.M. Wang; S.F. Tan; Q. Wang
10/30/2015
Genetics; Hepatocellular carcinoma; KRAS; Polymorphisms

KRAS, also known as V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, acts as an intracellular signal transducer. The oncogenic KRAS mutation is an essential step in the development of many types of human cancers, including hepatocellular carcinoma. Here we aimed to investigate the relationship between KRAS rs712 polymorphisms and hepatocellular carcinoma ... more

D. Xiong; Y.P. Song; W. Xiong; Y.D. Liang
10/09/2015
Chicken; Function annotation; miRNA-1757; Polymorphisms; Target gene

Single nucleotide polymorphism in microRNAs (miRNA) may influence their target gene selection and regulation efficiency, leading to animal phenotypic variation. The aim of this study was to evaluate the possible effect of single nucleotide polymorphisms in the miRNA-1757 gene precursor region (pre-mir-1757) on economic-related traits in chicken. Genotyping was performed using ... more

H. Li; K.R. Jiang; S.H. Wang; X.J. Liu; X.T. Kang; R.R. Jiang; Z.J. Li; G.R. Sun
03/04/2016
Atherothrombosis; Matrix metalloproteinase; Myocardial infarction; Polymorphisms

Several studies have demonstrated that matrix metalloproteinases (MMPs) play a major role in atherosclerotic plaque disruption and lead to myocardial infarction (MI). We investigated the association between the MMP1 -1607 1G/2G (rs1799750), MMP3 -1612 5A/6A (rs3025058), and MMP9 -1562 C/T (rs3918242) polymorphisms and the risk of developing MI in a ... more

J.M. Rodríguez-Pérez; G. Vargas-Alarcón; R. Posadas-Sánchez; T.X. Zagal-Jiménez; R. Ortíz-Alarcón; B. Valente-Acosta; C. Tovilla-Zárate; C. Nostroza-Hernández; O. Pérez-Méndez; N. Pérez-Hernández; J.M. Rodríguez-Pérez; G. Vargas-Alarcón; R. Posadas-Sánchez; T.X. Zagal-Jiménez; R. Ortíz-Alarcón; B. Valente-Acosta; C. Tovilla-Zárate; C. Nostroza-Hernández; O. Pérez-Méndez; N. Pérez-Hernández
10/30/2020
Glutathione-S-transferase; GSTM1; GSTT1; Oral cancer risk; Polymorphisms

The development of oral cancer results from interactions between genetic and environmental factors. Glutathione-S-transferase gene null polymorphisms have a strong impact on the detoxification of carcinogens; therefore they are expected to be related to oncogenic risk, including oral cancer. Various studies have evaluated a possible association of ... more

A.K. Lopes; A.L.M. Tacca; N.A. Nogueira; J.A. Sodario; C.A.S.T. Vilanova-Costa; V.A. Saddi; A.Vde Moraes Filho; A.M.T.C. Silva
11/30/2020
Adult-onset T1DM; Case-control study; Childhood-onset T1DM; IL-18; Polymorphisms; PTPN22

Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the destruction of pancreatic β-cells. Interleukins such as interleukin 18 (IL-18) and protein tyrosine phosphatase, nonreceptor type 22 (PTPN22) have been found to be associated with immune related diseases. We investigated a possible association of polymorphisms in IL-18 gene rs1946518 and ... more

L.P. Campos; V. Graciolo; M. Welter; M.S. Lopes; S. Nesi-França; G. Picheth; F.G.M. Rego

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