Research Article

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12/14/2015
Metastasis; MiR-134; Osteosarcoma; Prognosis; Proliferation

Dysregulation of microRNA (miR) is often associated with cancer development and progression. Aberrant expression of miR-134 has been found in some types of cancer. However, its expression and function in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-134 in osteosarcoma tumorigenesis and development. The expression level of miR-134 was quantified by ... more

Y. Bao; L. Peng; J. Ma; K. Liu; W. Li
11/13/2015
Invasion; miR-184; Osteosarcoma; Proliferation

Osteosarcoma is a highly malignant cancer that often appears in teenagers. It is the most frequently occurring primary bone tumor, and can easily metastasize, resulting in high mortality. MicroRNAs express abnormally in osteosarcoma, and may function as oncogenes or tumor suppressors. Recent studies showed that microRNA184 (miR-184) is abnormally expressed in multiple tumors, and is ... more

G.R. Yin; Q. Wang; X.B. Zhang; S.J. Wang
03/04/2016
Apoptosis; Hepatocellular carcinoma; Proliferation; ST2825

The purpose of this study was to investigate the effect of ST2825, an inhibitor of myeloid differentiation factor 88 (MyD88), on the proliferation and apoptosis of human hepatocellular carcinoma (HCC) cells as well as the potential mechanism and clinical significance of ST2825 in the treatment of HCC. Immunohistochemical staining with an MyD88 antibody was performed on tissues from 80 ... more

Y. Deng; J. Sun; L.D. Zhang; Y. Deng; J. Sun; L.D. Zhang
10/17/2016
Calf testis; Germline stem cells; Glial cell line-derived neurotrophic factor; Leukemia-inhibitory factor; Proliferation; Sperm differentiation

Germline stem cells are the only such capable of transmitting genetic information in vivo. The isolation and culture of these cells in vitro provide a unique model to understand sperm differentiation and hence, spermatogenesis and male fertility. In this study, we isolated, purified, and cultured germline stem cells from the testes of newborn ... more

P. Zheng; H. Huang; Y.G. Tian; Y. Zeng; E.O. Adegoke; X. Wang; G.X. Zhang; P. Zheng; H. Huang; Y.G. Tian; Y. Zeng; E.O. Adegoke; X. Wang; G.X. Zhang
09/25/2015
Apoptosis; Caspase 3; Lipid-associated membrane proteins; Mycoplasma hyopneumoniae

Lipid-associated membrane proteins (LAMPs) are important in the pathogenicity of the Mycoplasma genus of bacteria. We investigated whether Mycoplasma hyopneumoniae LAMPs have pathogenic potential by inducing apoptosis in a St. Jude porcine lung epithelial cell line (SJPL). LAMPs from a pathogenic strain of M. hyopneumoniae (strain 232) were used in the research. Our ... more

B. Ni; F.F. Bai; Y. Wei; M.J. Liu; Z.X. Feng; Q.Y. Xiong; L.Z. Hua; G.Q. Shao
09/09/2015
Apoptosis; Liver cirrhosis; Macrophage; Renal injury; Xiayuxue decoction

Renal pathological changes in cirrhotic rat have not been extensively reported. The aim of this study was to investigate whether Xiayuxue decoction (XYXD) could attenuate renal injury induced by bile duct ligation (BDL), with special focus on the mechanisms promoting renal macrophage apoptosis. The rats were treated with BDL for 5 weeks and administered 0.36 g/kg XYXD intragastrically from day ... more

C. Liu; J. Cai; Z. Cheng; X. Dai; L. Tao; J. Zhang; D. Xue
08/10/2015
Acute cerebral infarction; Apoptosis; Baculovirus P35 protein

We explored the effect of baculovirus P35 protein on apoptosis in the brain tissue of rats with acute cerebral infarction (ACI). A rat model of middle cerebral artery infarction was created. The rats were randomly divided into sham, model, and treatment groups. Baculovirus P35 protein was injected into the intracranial arteries of the treatment group rats. The rats in the model group were ... more

J.F. Ji; X.H. Ma
08/14/2015
5-aminolevulinic acid; Apoptosis; Sonodynamic therapy; UMR-106 cells

We investigated the killing effect of low-intensity ultrasound combined with 5-aminolevulinic acid (5-ALA) on the rat osteosarcoma cell line UMR-106. Logarithmic-phase UMR-106 cells were divided into a control group, ultrasound group and 5-ALA group. The cell apoptotic rate, production of reactive oxygen species, and the change in mitochondrial membrane potential were analyzed by flow ... more

Y.N. Li; Q. Zhou; B. Yang; Z. Hu; J.H. Wang; Q.S. Li; W.W. Cao
07/27/2015
Apoptosis; cFLIP; Corpus albicans; Corpus luteum; Porcine

We determined expression and localization of the anti-apoptotic cellular FLICE inhibitory protein (cFLIP) in the porcine corpora lutea (CL) and corpus albicans (CA) during estrous and preg­nancy. The CL and CA were collected at different stages of estrous to determine cFLIP immunolocalization, and mRNA and protein ex­pression. The mRNA expression of the short cFLIP isoform (cFLIPS ... more

H.Z. Jin; W.S. Shi; Y. Tian; Y. Liu; Y. Jin; N. Manabe
07/06/2015
Apoptosis; C-33A; Caspase; Cervical cancer; FoxO1; TNF-α

Tumor necrosis factor-α (TNF-α) is an important pro-apoptotic cytokine, which performs a broad range of immune and inflammatory functions in several vital processes. TNF-α-induced apoptosis has been confirmed, however, relatively little is known regarding the role of forkhead box class-O 1 (FOXO1) in mediating TNF-α-induced apoptosis in cervical cancer. In our study, we used the well- ... more

B. Zhang; L. Gui; L. Zhu; X. Zhao; Y. Yang; Q. Li

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