Research Article

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5/25/2017
Animals; Carcinosarcoma; Chromosome aberrations; Dogs; Female; genomic instability; Heterochromatin; Karyotype; Mammary Neoplasms, Animal; Ploidies

This study searched a rare and aggressive type of cancer in dogs and humans, the breast carcinosarcoma. Both clinical and pathological traits of mammary carcinosarcomas in dogs are similar to humans, such as infrequent occurrence, fast tumor growth, and unfavorable prognosis when compared to carcinomas. Other possible alterations include chromosomal abnormalities that can be useful for the ... more

C.S.D. Morais; P.R.A.M. Affonso; J.A. Bitencourt; A.A. Wenceslau
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Animals; Chromosomes; Female; Genotype; Hybridization, Genetic; Karyotype; Liver; male; Microsatellite Repeats; Polymorphism, Genetic; Quantitative Trait, Heritable; Transcriptome; Turtles

Chinese soft-shelled turtle Pelodiscus sinensis has been an important aquaculture species in Southeast Asian countries. To breed a new variety of soft-shelled turtle with excellent properties and to evaluate the effect of hybridization of two turtle strains with a highly different trait phenotype, inheritance, microsatellite loci, and transcriptome analysis were studied in the hybrid turtles ... more

H.Q. Zhang; X.J. Xu; Z.Y. He; J.Z. Shao; X.H. Zhang; Q.H. Meng; F.Y. Huang
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Arachis; Genome, Plant; Karyotype; Phylogeny; Polymorphism, Genetic; Principal component analysis

Arachis kuhlmannii occurs in Mato Grosso and Mato Grosso do Sul States, Brazil. Its area of occurrence partially overlaps with that of other species in the Arachis section. Because of their morphological similarities, these species are often mistaken one for another. This study aimed the correct classification of available accessions as Arachis kuhlmannii, or other species, and the ... more

A.P. Fávero; A.P.S. Peñaloza; C.R. Lopes; J.F.M. Valls
9/27/2017
Down syndrome; Heart Defects, Congenital; Humans; Infant; Karyotype; Klinefelter syndrome; male

Double aneuploidy is considered a rare phenomenon. Herein, we describe a case of double aneuploidy 48,XXY,+21 in a neonate with congenital heart defects. The 28-day-old neonate male (23-year-old mother and 24-year-old father) was admitted to a neonatal intensive care unit owing to congenital heart disease. Echocardiography showed a complete atrioventricular septal defect with Rastelli type B ... more

M.A. Rodrigues; L.F. Morgade; L.F.A. Dias; R.V. Moreira; P.D. Maia; A.F.H. Sales; P.D. Ribeiro
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Chromosomal alterations; Karyotype; Myelodysplastic syndrome; Phenotypes

Myelodysplastic syndrome (MDS), an onco-hematological disease, is characterized by distinct levels of peripheral blood cytopenia, cell differentiation dysplasia and various types of chromosomal alterations. The Revised International Prognostic Scoring System uses the GTG-banding karyotype as one of the main components for scoring patient prognosis in MDS. Using GTG ... more

C.L. Ribeiro; I.P. Pinto; M.O. Diogo; D.Mda Cruz e Cunha; L.B. Minasi; F.S.M. Kluthcouski; A.D. da Cruz; C.C. da Silva
03/30/2020
AZFc; Infertility; Karyotype; Sox9 gene; SRY

Sex differentiation in males is a highly complex phenomenon based on synergistic interactions between genes and their coded proteins. The Sox9 gene plays a critical role in embryonic development, cell lineages, and stem cell maintenance during testicular development. Sox9 gene expression is associated with sex reversal, with a 46, XX karyotype in males and ... more

A.K. Saxena; M. Tiwari; R. Kumar; Aprajita; A. Kumar; C.K. Singh; M. Agarwal
07/13/2022
Chromosomal sex; Determination of sex; Karyotype; Multiplex fluorescent PCR; Sex chromosomal abnormalities

Quantitative PCR puts great demands on DNA quality and relies on a comparison of fragment amplification between two chromosomes using different primers. The use of a single primer pair capable of reliable relative comparative amplification would be a great advantage.  Using this approach, we developed a rapid, high-throughput, semi-automated and cost-efficient ... more

J.L.F. Rocha; H.B. Pena; S.D.J. Pena

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