Research Article

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Breed; Chicken FTO; Hypothalamus; Liver; Skeletal muscle

The fat mass- and obesity-associated gene (FTO) is involved in energy metabolism, but little is known about the chicken FTO gene. The objective of the current study was to detect chicken FTO expression patterns in the hypothalamus, liver, and skeletal muscle during development, and analyze the effects of age and breed on FTO expression. Real-time quantitative polymerase chain reaction results ... more

C. Song; W.T. Song; J.T. Shu; Z.Y. Tao; W.Q. Zhu; C. Di; H.F. Li
Akirin2 expression; Bursa; Chicken; Immune response; Liver

Akirin2 is a nuclear factor that plays an important role in the development and regulation of innate immune response. In this study, akirin2 gene expression in several primary immune organs (liver, thymus, and bursa) of Hi-Line Brown chicken administered with the LoSota vaccine was analyzed during the various stages of increase in Newcastle disease virus antibody titer. The ... more

C.L. Man; W.T. Mu; Y. Chang; D.X. Zhao
Chemical treatment; Dendritic cells; Immune treatment; Liver; Metastasis; Recurrence

We aimed to evaluate dendritic cell (DC) tumor vaccines for preventing liver cancer recurrence and metastasis. DCs were induced from mononuclear cells in the peripheral blood with recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) and recombinant human interleukin 4 (rhIL-4), followed by sensitization with lysis of autologous liver cancer cells. One hundred and ... more

T.Y. Sun; W. Yan; C.M. Yang; L.F. Zhang; H.L. Tang; Y. Chen; H.X. Hu; X. Wei
Antioxidant enzymes; Environmental static electric field; Liver

With the increasing voltage of direct current transmission line, the intensity of the environmental static electric field has also increased. Thus, whether static electric fields cause biological injury is an important question. In this study, the effects of chronic exposure to environmental static electric fields on some antioxidant enzymes activities in the hepatocytes of mice were ... more

S.X. Wu; Y.Q. Xu; G.Q. Di; J.H. Jiang; L. Xin; T.Y. Wu; S.X. Wu; Y.Q. Xu; G.Q. Di; J.H. Jiang; L. Xin; T.Y. Wu
Adult; Biomarkers; Case-control studies; Cells, Cultured; Chelating Agents; Combined Modality Therapy; Female; Hepatolenticular Degeneration; Humans; Liver; Liver cirrhosis; male; Mesenchymal Stem Cell Transplantation; Mesenchymal stem cells; Penicillamine; Transforming Growth Factor beta1; Treatment outcome; Tumor necrosis factor-alpha; Young Adult

The efficacy of bone marrow mesenchymal stem cell (BMSC) on liver fibrosis in animal has been proven, but a few studies have been made in human body and few such researches in China. This study was designed to investigate the effect of BMSC treatment on hepatic fibrosis induced by hepatolenticular degeneration and the influence on serological indicators. Sixty patients with liver fibrosis ... more

D. Zhang
Animals; Apoptosis; Blood glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Ginsenosides; Glucose; Insulin; JNK Mitogen-Activated Protein Kinases; Lipids; Liver; Liver Diseases; male; Random Allocation; Rats; Rats, Sprague-Dawley

Type 2 diabetes mellitus (T2-DM) is a chronic metabolic disorder characterized by high blood glucose levels. T2-DM patients suffer from many complications, such as diabetic fatty liver and diabetic nephropathy. The liver, the pivotal organ involved in both glucose and lipid metabolism, is primarily damaged in T2-DM patients, especially in those with high levels of blood lipid. In this study, ... more

W. Tian; L. Chen; L. Zhang; B. Wang; X.B. Li; K.R. Fan; C.H. Ai; X. Xia; S.D. Li; Y. Li
Animals; Brain; Cloning, Molecular; Fish Proteins; Fishes; Kidney; Liver; Muscle, Skeletal; Receptors, Glucocorticoid; Sodium Chloride; Stress, Physiological

To understand the regulation of the glucocorticoid receptor gene (Gcr) during loading and transport stress in fish, the Gcr gene of Coilia nasus was cloned. Gcr in C. nasus is expressed strongly in the liver and muscle, and less stronglyin the gills, brain, spleen, intestine, trunk kidney, and head kidney. Gcr expression in both the liver and muscle was increased by loading and transport ... more

F.K. Du; G.C. Xu; Y. Li; Z.J. Nie; P. Xu
Adipose tissue; Animals; Antioxidants; Body weight; Camellia sinensis; Chromosomal Proteins, Non-Histone; Chronotherapy; Circadian rhythm; Diet; Eating; Female; Homeostasis; Lipid metabolism; Liver; Liver X Receptors; Mice; Ovary; Oxidation-Reduction; Plant Extracts; Tea

Biological rhythms can be defined as changes in physiological or behavioral variables that repeat at certain time intervals. Rhythms that last approximately 24 h are referred to as circadian rhythms. Modern lifestyles have drastically affected human habits, as well as the population's eating habits. These changes have generated an epidemic of metabolic syndromes, such as obesity and diabetes. ... more

R.P. Amorim; I.P. Daher; F.P.D. Arcangelo; M.F. Bellini; W.A. Orcini; G.R. Sarria; R.L. Peruquetti
Animals; Chromosomes; Female; Genotype; Hybridization, Genetic; Karyotype; Liver; male; Microsatellite Repeats; Polymorphism, Genetic; Quantitative Trait, Heritable; Transcriptome; Turtles

Chinese soft-shelled turtle Pelodiscus sinensis has been an important aquaculture species in Southeast Asian countries. To breed a new variety of soft-shelled turtle with excellent properties and to evaluate the effect of hybridization of two turtle strains with a highly different trait phenotype, inheritance, microsatellite loci, and transcriptome analysis were studied in the hybrid turtles ... more

H.Q. Zhang; X.J. Xu; Z.Y. He; J.Z. Shao; X.H. Zhang; Q.H. Meng; F.Y. Huang
Animals; Cadmium; Cadmium Poisoning; Eels; Fish Proteins; Fresh Water; Liver; Metallothionein; Thailand; Water Pollution, Chemical

Cadmium (Cd) is produced mainly as a by-product of zinc mining. In Thailand, the largest zinc mine is located in the Mae Sot district, Tak Province. Samples of Monopterus albus were collected from paddy fields in 4 sites, three downstream and one upstream from the zinc mine. The upstream site was considered to be uncontaminated while the three downstream sites were considered to be ... more

M. Wahid; S. Prasarnpun; N. Yimtragool