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Related GMR Articles

Genetic polymorphisms; Glutathione S-transferase; SA; Turabah

Glutathione-S-transferases (GST) are key phase II detoxifying enzymes that play critical roles in protection against products of oxidative stress and against electrophiles. Glutathione S-transferase mu (GST-M1) and theta (GST-T1) are isoforms of glutathione transferase enzymes that participate in the metabolism of a wide range of chemicals. Deletion variants ... more

A.A. Mansour; O.M. Saleh; T. Askar; A.M. Salim; A. Mergani
Brazil; Glutathione S-transferase; Polymorphism

The glutathione S-transferase (GST) family of enzymes has a vital role in phase II of biotransformation of environmental carcinogens, pollutants, drugs and other xenobiotics. GSTs are polymorphic, with the type and frequency of polymorphism being ethnic dependent. Polymorphisms in GST genes have been shown to be associated with susceptibility to disease and disease outcome. We ... more

A. Rossini; D.C.M. Rapozo; L.M.F. Amorim; J.M.B. Macedo; R. Medina; J.F.N. Neto; C.V.M. Gallo; L.F.R. Pinto
Glutathione S-transferase; Multiplex PCR; Polymorphism; Type-2 diabetes mellitus

Glutathione S-transferase (GST) protects cells against oxidative stress. We evaluated the effect of genetic polymorphisms of the GST gene family on the risk of developing type-2 diabetes mellitus and on glycemic control. We also investigated the effects of smoking combined with these polymorphisms on type-2 diabetes mellitus risk. We enrolled 100 type-2 diabetes mellitus patients and 100 ... more

M.A. Amer; M.H. Ghattas; D.M. Abo-ElMatty; S.H. Abou-El-Ela
Chronic obstructive pulmonary disease; Genetic polymorphism; Glutathione S-transferase

Chronic obstructive pulmonary disease (COPD) is a multifactorial disease with possible genetic predisposition and involvement of various environmental factors. Several candidate genes have been reported as potentially associated with this lung disease. The glutathione S-transferase P1 gene (GSTP1) was proposed to be involved in susceptibility to develop COPD. It belongs to the ... more

R. Lakhdar; S. Denden; J. Knani; N. Leban; H. Daimi; M. Hassine; G. Lefranc; J. Ben Chibani; H. Khelil
Alkaline phosphatase; Cantharidin; Glutathione S-transferase; Helicoverpa armigera

The molecular and biochemical effects of an insecticidal toxin extracted from Meloidae beetles were investigated on Helicoverpa armigera. The toxin was identified as cantharidin, a well-known natural compound produced by beetles of family Meloidae and Oedemeridae. Furthermore, the effect of the toxin on the metabolic enzymes alkaline phosphatase (ALP) and glutathione S- ... more

R.A. Khan; M. Rashid; D. Wang; Y.L. Zhang
Camelina sativa; CMGSTF12; Glutathione S-transferase; TT19

Recently, we found that the Arabidopsis TT19 protein, a glutathione S-transferase, has two functional domains that influence both anthocyanin and proanthocyanidin accumulation. To further understand the function of this protein in the other species, we cloned a cDNA encoding a glutathione S-transferase (namely CMGSTF12) from Camelina sativa, an ... more

Y. Wang; Y. Tang; M. Zhang; F. Cai; J. Qin; Q. Wang; C. Liu; G. Wang; L. Xu; L. Yang; J. Li; Z. Wang; X. Li
Glaucoma; Glutathione S-transferase; GSTM1; GSTT1

In this study, we evaluated the genotype profile of GSTM1 and GSTT1 polymorphisms in patient carriers of primary open-angle glaucoma in the population of Goiânia, GO, Brazil. This case-control study included 100 Brazilian patients with glaucoma and 53 patients without glaucoma. Blood samples were genotyped for polymorphisms in GST genes using polymerase chain reaction-based ... more

C.T.X. Silva; N.B. Costa; K.S.F. Silva; R.E. Silva; K.K.V.O. Moura
Acute myeloid leukemia; Glutathione S-transferase; Polymorphisms

We aimed to investigate the relationships between polymorphisms of the glutathione S-transferases (GSTs) GSTM1, GSTTI, and GSTP1 and the risk of developing acute myeloid leukemia (AML). A total of 206 AML cases and 231 controls were collected for our study. The genotyping of GSTs (GSTM1, GSTTI, and GSTP1) was based upon the duplex ... more

Y.M. Zi; S. Wu; D. Ma; C. Yang; M. Yang; Y. Huang; S.J. Yang
Cardiovascular disease; Glutathione S-transferase; Malaysia; Type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) is believed to be associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress, and have been associated with cardiovascular disease (CVD). The present study assessed the effect of GST polymorphisms on the ... more

A. Etemad; R. Vasudevan; A.F.A. Aziz; A.K.M. Yusof; S. Khazaei; N. Fawzi; S. Jamalpour; M. Arkani; N.A. Mohammad; P. Ismail; A. Etemad; R. Vasudevan; A.F.A. Aziz; A.K.M. Yusof; S. Khazaei; N. Fawzi; S. Jamalpour; M. Arkani; N.A. Mohammad; P. Ismail; A. Etemad; R. Vasudevan; A.F.A. Aziz; A.K.M. Yusof; S. Khazaei; N. Fawzi; S. Jamalpour; M. Arkani; N.A. Mohammad; P. Ismail
Amerindians; Brazilian population; DARC; DNA polymorphism; Duffy blood group; Genetic polymorphisms

Ala100Thr has been suggested to be a Caucasian genetic marker on the FY*B allele. As the Brazilian population has arisen from miscegenation among Portuguese, Africans, and Indians, this mutation could possibly be found in Euro- and Afro-Brazilians, or in Brazilian Indians. Fifty-three related individuals and a random sample of 100 subjects from the Brazilian population were investigated ... more

A.Cristina Estalote; R. Proto-Siqueira; W.Araújo Da Silva; M.Antonio Zago; M. Palatnik