Research Article

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J.Y. Ban; J.I. Shin; C.H. Oh
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APOA-I; APOE; Coronary heart disease; HDL-C; High-density lipoprotein cholesterol; Polymorphism

Apolipoprotein E (APOE) is recognized for its importance in lipoprotein metabolism and cardiovascular disease. We evaluated the association between APOE rs4420638 genotypes and circulating lipid concentrations along with the risk of coronary heart disease (CHD). We conducted a case-control study involving 1508 individuals to investigate the contribution of rs4420638 to ... more

Y. Huang; H.D. Ye; X. Gao; S. Nie; Q.X. Hong; H.H. Ji; J. Sun; S.J. Zhou; B. Fei; K.Q. Li; J.K. Zhao; Z.P. Wang; M.Q. Xu; S.W. Duan
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Polymorphism; Retinal vein occlusion; RVO; Thrombophilia

In this study, we assessed the prevalence of polymorphisms in genes involved in hyperhomocysteinemia or hemostasis to shed light on their role, if any, in retinal vein occlusion (RVO). We recruited 37 Italian patients (17 men and 20 women) with a diagnosis of central or branch RVO based on fundus examination and retinal fluorescein angiography, as well as 45 healthy controls. Risk ... more

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Chronic obstructive pulmonary disease; Polymorphism; Proteinase-activated receptor-1

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The A-20C polymorphism in the angiotensinogen (AGT) gene has been associated with increased risk of essential hypertension in several studies; however, these studies gave inconsistent results. In this study, we performed a meta-analysis to assess the association between AGT A-20C polymorphism and essential hypertension. Published literature was retrieved from PubMed. ... more

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Censured data; Mixed model; Polymorphism

The aim of this study was to compare genomic selection methodologies using a linear mixed model and the Cox survival model. We used data from an F2 population of pigs, in which the response variable was the time in days from birth to the culling of the animal and the covariates were 238 markers [237 single nucleotide polymorphism (SNP) plus the halothane gene]. The data were corrected ... more

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