Research Article

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08/07/2015
Beta vulgaris; Bioinformatics; EST; GSS; MicroRNA

Highly conserved endogenous non-coding microRNAs (miRNAs) play important roles in plants and animals by silencing genes via destruction or blocking of translation of homologous mRNA. Sugar beet, Beta vulgaris, is one of the most important sugar crops in China, with properties that include wide adaptability and strong tolerance to salinity and impoverished soils. Seedlings of ... more

J.L. Li; J. Cui; D.Y. Cheng
12/11/2015
Bioinformatics; Clone; LOC339524 gene; Sprague-Dawley rat (Rattus norvegicus)

We cloned the LOC339524 gene in Sprague-Dawley (SD) rats and analyzed the structure and function of the protein encoded by it. Based on the known human LOC339524 gene sequences, the full-length coding sequence of the LOC339524 gene in SD rats was cloned and amplified by the polymerase chain reaction using the complementary DNA of SD rats as a template. Bioinformatics analysis showed that ... more

Z.H. Long; H. Li; F. Chen; L.Y. Zou
10/30/2015
Bacteria; Bioinformatics; Fungi; Laccase; Oomycetes; Plant pathogen

To date, research on laccases has mostly been focused on plant and fungal laccases and their current use in biotechnological applications. In contrast, little is known about laccases from plant pathogens, although recent rapid progress in whole genome sequencing of an increasing number of organisms has facilitated their identification and ascertainment of their origins. In this study, a ... more

B.Z. Feng; P.Q. Li; L. Fu; X.M. Yu
10/28/2015
Alveolar bone cell; Bioinformatics; Biological pathway; Diabetes

Alveolar bone osteoblasts are widely used in dental and related research. They are easily affected by systemic diseases such as diabetes. However, the mechanism of diabetes-induced alveolar bone absorption remains unclear. This study systematically explored the changes in human alveolar bone cell-related gene expression and biological pathways, which may facilitate the investigation of ... more

X. Sun; Q.H. Ren; L. Bai; Q. Feng
10/16/2015
Bioinformatics; Chordates; Evolutionary biology; Myogenic regulatory factors

MyoD and MyoG are transcription factors that have essential roles in myogenic lineage determination and muscle differentiation. The purpose of this study was to compare multiple amino acid sequences of myogenic regulatory proteins to infer evolutionary relationships among chordates. Protein sequences from Mus musculus (P10085 and P12979), human Homo sapiens (P15172 and ... more

L.C. Oliani; K.C.F. Lidani; J.E. Gabriel
03/28/2016
Bioinformatics; Identification; MicroRNA; Middleware; RNA sequencing; Web server

This report describes the miRQuest - a novel middleware available in a Web server that allows the end user to do the miRNA research in a user-friendly way. It is known that there are many prediction tools for microRNA (miRNA) identification that use different programming languages and methods to realize this task. It is difficult to understand each tool and apply it to diverse datasets ... more

R.R. Aguiar; L.A. Ambrosio; G. Sepúlveda-Hermosilla; V. Maracaja-Coutinho; A.R. Paschoal; R.R. Aguiar; L.A. Ambrosio; G. Sepúlveda-Hermosilla; V. Maracaja-Coutinho; A.R. Paschoal; R.R. Aguiar; L.A. Ambrosio; G. Sepúlveda-Hermosilla; V. Maracaja-Coutinho; A.R. Paschoal
06/18/2019
Bioinformatics; Conserved domains; Homology modeling

The Allium genus stands out for its uses in human food and also for its medicinal properties. Many representatives of the Amaryllidaceae family are known for producing mannose binding lectins (MBL). In plants, lectins act as reserves of proteins that can be used for plant growth and development and also in defense against herbivores and pathogens, being ... more

H.J. Jimenez; L.S.S. Martins; R. Carvalho; A.V.V. Montarroyos; R.M.Moraes Filho
06/30/2020
Alpha-galactosidase; Bioinformatics; Functional prediction; Hypothetical proteins; Penicillium rubens

Advances in biotechnology and molecular biology fields have allowed the sequencing of species genomes to improve the understanding of their genetics. As a consequence of the large number of whole genome sequencing projects, various DNA and protein sequences predicted by bioinformatics still without an identified function and are annotated in data banks as ... more

F.F. Silva; D.B. Gonçalves; D.O. Lopes