Research Article

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In this study, we investigated the effects of pingyangmycin (PYM) on the growth inhibition and apoptosis of human umbilical vein endothelial cells (HUVEC). In this study, we aimed to explore the optimal concentration of PYM to induce the apoptosis of HUVEC and to determine its mechanism of action. After treatment of HUVEC with different concentrations of PYM for 24 h, cell counting kit-8 (CCK- ... more

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Since there are no studies on the reversal of multidrug resistance by curcumin in the human colorectal cancer cell line HCT-8/5-FU, our aim was to search for highly efficient reversal agents and investigate the underlying mechanisms of this reversal. The cytotoxic effects of curcumin and 5-FU on HCT-8 and HCT-8/5-FU cells and the reversal effects of 5-FU in combination with curcumin on HCT-8/5 ... more

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Apoptosis; ERK signal pathway; Hepatic stellate cells; JNK signal pathway
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Glioblastoma is considered incurable, even with a combination of therapies (chemo and radiotherapy), and surgical resection. New therapeutic approaches are needed to improve the prognosis of patients with glioblastoma. In recent decades, research has focused on molecular biology of brain tumors. We examined the role of programmed cell death, apoptosis, through two ... more

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Pancreatic adenocarcinoma (PA) is one of the most aggressive malignant tumors of the digestive tract, with a five-year survival rate of 5%. Early detection offers better possibilities of cure; however, in early stages it does not present symptoms, making the management of these patients difficult. The most commonly used biomarker for diagnosis of PA is serum CA19-9 ... more

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It is known that mesothelin (MSLN) is overexpressed in some cancers, and that it plays a role in cell growth through Wnt family member 1 protein. Malignant transformation usually occurs with disruption of autoregulation of autophagy-related genes. We examined the effect of MSLN on survival and clinicopathological features in mesothelioma cases, as well as ... more

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Differentially expressed gene; MicroRNA; Pancreatic adenocarcinoma

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Beta vulgaris; Bioinformatics; EST; GSS; MicroRNA

Highly conserved endogenous non-coding microRNAs (miRNAs) play important roles in plants and animals by silencing genes via destruction or blocking of translation of homologous mRNA. Sugar beet, Beta vulgaris, is one of the most important sugar crops in China, with properties that include wide adaptability and strong tolerance to salinity and impoverished soils. Seedlings of ... more

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Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In this study, we assessed the ... more

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