Research Article

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12/02/2016
Animals; Apoptosis; Cells, Cultured; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Gonadotropins, Equine; Horses; In Vitro Oocyte Maturation Techniques; Oocytes; Receptors, FSH; Receptors, LH; Receptors, LHRH; Sheep

We assessed the effects of equine chorionic gonadotropin (eCG) on oocyte in vitro maturation (IVM), apoptosis, and follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), and gonadotropin-releasing hormone receptor (GnRHR) expression and mRNA levels. Cumulus-oocyte complexes (COCs) were recovered from sheep ovaries and pooled in groups, before being cultured in IVM ... more

S.C. Wei; Z.D. Gong; H.W. Zhao; H.Q. Liang; L.J. Lai; Y.Y. Deng
12/19/2016
Adult; Aged; Apoptosis; Bone neoplasms; Caspase 8; Cell proliferation; Cell survival; Female; Gene Expression Regulation, Neoplastic; Humans; male; Middle Aged; Osteochondroma; Osteosarcoma; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Young Adult

Osteosarcoma is a common malignant bone tumor that mainly affects children and adolescents. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor superfamily. Caspase-8 appears in the upstream of apoptosis signaling pathway among caspases. We investigated TRAIL and caspase-8 levels in osteosarcoma patients to determine their correlation with ... more

X. Ning; X.W. Shang; Y. Zhuang; M. Liu; H. Yang; H. Zhang; M.Z. Huang
1/23/2017
Apoptosis; Cell Line, Tumor; Cell proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Proto-Oncogene Proteins c-bcl-2; RNA interference; Uterine cervical neoplasms

Cervical carcinoma is a life-threatening illness posing considerable danger to women's health. microRNAs (miRNAs) have been shown to regulate multiple cellular events, including growth and proliferation, and miR-187 is thought to regulate the growth and apoptosis of certain cell types. Our study focused on the influence of miR-187 on the growth, proliferation, and apoptosis of SiHa cervical ... more

C.Y. He; J. Yang
1/23/2017
Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell proliferation; Cell survival; Cisplatin; Drug Resistance, Neoplasm; Female; Humans; Ovarian Neoplasms; RNA, Long Noncoding

The objective of this study was to investigate the effect of downregulating long non-coding RNAs (lncRNAs) on the reversal of cisplatin resistance in CP70 ovarian cancer cells, and to identify the underlying mechanism(s) of action. An lncRNA microarray was performed to screen for downregulated lncRNAs in cisplatin-resistant CP70 cells. Expression levels of these lncRNAs were then verified in ... more

H. Yan; J.Y. Xia; F.Z. Feng
2/23/2017
Apoptosis; Blotting, Western; Breast neoplasms; Cell Line, Tumor; Cell Movement; Cell proliferation; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Down-regulation; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; MCF-7 cells; MicroRNAs; Microscopy, Electron; Neoplasm Invasiveness; Neoplasm Metastasis; Reverse Transcriptase Polymerase Chain Reaction; Transcription factors

Breast cancer, which derives from the epithelium of the mammary glands, is one of the most common cancers diagnosed in women globally. To date, the authors of many studies have reported that the deregulation of microRNAs (miRNAs) plays a crucial role in the occurrence, development, and metastasis of tumors. Here, we discovered that miR-660-5p was upregulated in the breast cancer cell lines ... more

Y. Shen; Y.F. Ye; L.W. Ruan; L. Bao; M.W. Wu; Y. Zhou
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Adaptor Proteins, Signal Transducing; Adult; Aged; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell proliferation; Down-regulation; Female; Genes, Tumor Suppressor; Humans; KB Cells; male; MicroRNAs; Middle Aged; Monomeric GTP-Binding Proteins; Mouth Neoplasms; RNA, Messenger

Ras association domain family member 5 (RASSF5), a member of the Ras association domain family, induces cell apoptosis by phosphorylating FOXO3a, which triggers target gene BIM (pro-apoptotic factor) activation. MiR-214 is overexpressed in oral cancer tissue, indicating its possible involvement in oral cancer pathogenesis. Bioinformatics analysis has revealed a complimentary sequence between ... more

T.K. Li; K. Yin; Z. Chen; Y. Bao; S.X. Zhang
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Actins; Apoptosis; Cell proliferation; Cells, Cultured; Coculture Techniques; Down-regulation; Hepatic stellate cells; Hepatocyte growth factor; Humans; Mesenchymal stem cells; Paracrine Communication

We investigated the paracrine effects of bone marrow mesenchymal stem cells (BMSCs) on the proliferation, apoptosis, and alpha-actin-2 (ACTA2) expression of hepatic stellate cells (HSCs), and explored the possible mechanisms of hepatocyte growth factor (HGF). We established a co-culture system by culturing BMSCs on the upper layer and HSCs on the lower layer of a 6-well Transwell plate. Normal ... more

H.J. Cao; M.D. Wang; S.G. Li; L. Zhu; J.H. Zheng
3/30/2017
3' Untranslated Regions; AC133 Antigen; Apoptosis; Cell cycle; Cell Line, Tumor; Cell Movement; Cell proliferation; Gene Expression Regulation, Neoplastic; Glioma; Humans; MicroRNAs; Nervous System Neoplasms; RNA, Messenger; Transfection

MiR-200b, a member of the microRNA-200 family, has been identified to be capable of suppressing glioma cell growth through targeting CREB1 or CD133. However, whether miR-200b affects the biological behavior (proliferation, invasion, and migration) of glioma cells is poorly understood. The aim of this study was to evaluate the effect of miR-200b on the biological behavior of glioma cells in ... more

C. Zhao; Z.G. Ma; S.L. Mou; Y.X. Yang; Y.H. Zhang; W.C. Yao
3/30/2017
Animals; Apoptosis; Blood glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Ginsenosides; Glucose; Insulin; JNK Mitogen-Activated Protein Kinases; Lipids; Liver; Liver Diseases; male; Random Allocation; Rats; Rats, Sprague-Dawley

Type 2 diabetes mellitus (T2-DM) is a chronic metabolic disorder characterized by high blood glucose levels. T2-DM patients suffer from many complications, such as diabetic fatty liver and diabetic nephropathy. The liver, the pivotal organ involved in both glucose and lipid metabolism, is primarily damaged in T2-DM patients, especially in those with high levels of blood lipid. In this study, ... more

W. Tian; L. Chen; L. Zhang; B. Wang; X.B. Li; K.R. Fan; C.H. Ai; X. Xia; S.D. Li; Y. Li
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Breast cancer adversely affects the health status of women; therefore, the prevention and treatment of breast cancer is of critical importance. Lycopene is known to possess several biological effects such as removal of free radicals, alleviation of biological oxidative injury, and inhibition of tumor growth. In this study, we aimed to illustrate the effect of lycopene on tumor cell ... more

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