Research Article

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12/09/2015
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The purpose of this study was to explore the radiotherapy sensitization effects and the mechanism of capecitabine (Xeloda) against the non-small-cell lung cancer cell line, A549. γ-[60Co] radiation was used as the intervention method. Proliferative inhibition of capecitabine on A549 cells was determined by the CCK-8 method. The effects of capecitabine on the apoptosis rate and ... more

J.J. Zhu; J.J. Shan; L.B. Sun; W.S. Qiu
11/30/2015
Apoptosis; HepG2 cell; Liver cancer; Wilfortrine

Liver cancers are characterized by high morbidity and mortality owing to few effective drugs for its treatment. Wilfortrine has several pharmacological effects, including an inhibitory effect on liver cancer cell proliferation. However, whether wilfortrine can induce liver cancer cell apoptosis has not been elucidated. We investigated the role of wilfortrine on liver cancer cell HepG2 ... more

M. Yue; X.J. Shen; Y.X. Liu; X.Y. Lin; S.Q. Zhou; Y.H. Song
12/02/2015
Apoptosis; Cytotoxicity; Dihydromyricetin; Gastric cancer; p53

The aim of the present study was to determine the anti­proliferative and pro-apoptotic effects of dihydromyricetin (DHM) on the AGS human gastric cancer cells and their underlying mechanisms. The effects of DHM on AGS cells were evaluated by using 3-(4, 5-di­methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase, and Annexin V/propidium iodide (PI) double- ... more

F.J. Ji; X.F. Tian; X.W. Liu; L.B. Fu; Y.Y. Wu; X.D. Fang; H.Y. Jin
11/23/2015
Apoptosis; Cell proliferation; Checkpoint kinase 1; Gamma-aminobutyric acid type A receptor; p53; Propofol

We investigated the effect of propofol on the proliferation and viability of rat embryonic neural stem cells (rENSCs) and the potential mechanisms involved. rENSCs were isolated and cultured in vitro and treated with 1, 10, or 50 μM propofol, while the control group was treated with 0.1 μM dimethyl sulfoxide. The effect of propofol on the proliferation and viability of rENSCs was ... more

J.W. Wang; W.W. Cheng; T. Xu; Z.Y. Yang
10/21/2015
Apoptosis; Cellular FLICE inhibitory protein; Corpus luteum; Estrous cycle; Shiba goat

Changes in the expression of the anti-apoptotic protein cFLIP (cellular FLICE inhibitory protein) were examined in the caprine corpus luteum (CL), during development and subsequent maintenance. Corpora lutea at four different stages were collected from Shiba goats, to measure the expression of cFLIP mRNA, protein and immunolocalization. Expression of short form cFLIP (cFLIPS) ... more

H.Z. Jin; Y. Wang; Y. Liu; X.P. Li; Y. Jin
02/05/2016
Apoptosis; Docetaxel; G2/M cell cycle; Human renal cell carcinoma

Tremendous efforts have been made in renal cell carcinoma (RCC) patients’ research; however, clinical findings in patients have been disappointing. The aims of our study were to identify better or alternative therapeutic methods that can reverse chemotherapy resistance and to enhance sensitivity to docetaxel (DOX)-based chemotherapy drugs. We evaluated the anti-proliferative effect of DOX ... more

T.D. Han; D.H. Shang; Y. Tian; T.D. Han; D.H. Shang; Y. Tian
10/17/2016
Apoptosis; C-erbB-2; Chitosan; Laryngeal cancer; Nanoparticles

We aimed to measure the invasion ability of Hep-2 laryngeal cancer cells after treatment with C-erbB-2-small interfering RNA (siRNA)-chitosan nanoparticles, and assess the applied value of chitosan nanoparticle-mediated C-erbB-2 interference in inhibiting laryngeal cancer invasion and metastasis. Nanoparticles of approximately 100 nm, comprising ... more

W.R. Liu; L.R. Cao; G.J. Zuo; W.R. Liu; L.R. Cao; G.J. Zuo
11/03/2016
Apoptosis; miR-1; Proliferation; Vestibular schwannoma

A growing body of research has demonstrated the tumor suppressive function of microRNA (miR)-1 in many cancers. Our study aimed to investigate its role in vestibular schwannoma (VS). We examined miR-1 expression in 95 VS specimens and 79 normal vestibular nerves using quantitative real-time polymerase chain reaction. Moreover, miR-1 ... more

S.L. Li; X.H. Ma; J.F. Ji; H. Li; W. Liu; F.Z. Lu; S.T. Wu; Y. Zhang
11/21/2016
Apoptosis; Bcl-xL; Cervical cancer c-33a cells; miRNA 421

Cervical cancer is a life-threatening condition. MicroRNAs (miRNAs) can promote or inhibit cell death and proliferation. The present study investigated the effect of miRNA 421 on the growth and apoptosis of cervical cancer cells. miRNA 421 and control miRNA were synthesized and transfected into c-33a cervical cancer cells. A thiazolyl ... more

X.J. Lai; X.Y. Cheng; L.D. Hu
11/21/2016
Apoptosis; bcl-X Protein; Cell Line, Tumor; Cell proliferation; Cell survival; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Uterine cervical neoplasms

Cervical cancer is a life-threatening condition. MicroRNAs (miRNAs) can promote or inhibit cell death and proliferation. The present study investigated the effect of miRNA 421 on the growth and apoptosis of cervical cancer cells. miRNA 421 and control miRNA were synthesized and transfected into c-33a cervical cancer cells. A thiazolyl blue tetrazolium bromide assay, caspase-3 activity, and ... more

X.J. Lai; X.Y. Cheng; L.D. Hu

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