Research Article

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11/30/2019
Brain ischemia; MicroRNA; Neurotransmitter; Physical exercise

Cerebral ischemia is one of the main causes of death in Brazil, according to a survey by the Brazilian Society of Neurology in 2000, being the third cause of death after cardiovascular diseases and cancer; it is also one of the major causes of permanent sequels that can result in disability. In the last decades, experimental studies have shown beneficial effects of ... more

M.L.A. Cirino; L.B. Porsani; F.S.Lizarte Neto; M.F.G.S. Tazima; R.F. Zimak; C.G. Carlotti; B.O. Colli; L.F. Tirapelli; D.P.C. Tirapelli
08/31/2020
Alcoholism; Apoptosis; blood; Cerebral ischemia; miRNA; morphology

One of the main global causes of mortality is cerebral ischemia. Studies report that alcohol abuse causes health problems, aggravating the conditions of neurological diseases. The role of microRNAs has been highlighted in the literature as biomarkers in various types of diseases, including neurological disorders. Evidence of dysregulation of serum miRNAs related to ... more

P.C. Novais; F.S.L. Neto; M.Lde A. Cirino; L.B. Porsani; J.P. da Silva; I.S. Gula; deT. Durand; C.A.M. de Carvalho; B.C. Schimming; deF.G.S. Tazima; C.G. Carlotti; B.O. Colli; D.Pda C. Tirapelli; L.F. Tirapelli
12/31/2020
Alcoholism; Apoptosis; Cerebral ischemia; miRNA-21; morphology

Cerebral ischemia is one of the main causes of morbidity and mortality as Abusive use of alcohol also causes health problems, along with considerable social and economic repercussions. We examined how these two conditions affect histopathological signs, morphometrics, expression of apoptosis-related proteins CASPASE 3 and BCL2, and serum gene expression of miRNA-21 ... more

D.P.C. Tirapelli; M.L.A. Cirino; J.P. da Silva; I.S. Gula; M.F.G.S. Tazima; V.P.S. Fazan; C.A.M. de Carvalho; P.C. Novais; F.S.Lizarte Neto; M.T. Durand; B.C. Schimming; C.G.Carlotti Junior; B.O. Colli; L.F. Tirapelli
10/17/2016
Congenital heart disease; MicroRNA; miR-196a2; Single nucleotide polymorphisms

We hypothesized that single nucleotide polymorphisms (SNPs) in certain microRNAs contribute to congenital heart disease (CHD) phenotypes. Five hundred and seventy-three subjects were enrolled in this study. DNA extracted from peripheral blood cells was used for SNP genotyping of miR-196a2 (rs11614913), miR-27a (rs11671784, rs895819), and miR-499 (rs3746444). Allele ... more

K. Yu; Y. Ji; H. Wang; Q.K. Xuan; B.B. Li; J.J. Xiao; W. Sun; X.Q. Kong
09/23/2016
Cerebral ischemia; Inflammation; p38MAPK

Inflammation plays an important role in cerebral ischemia reperfusion, which can cause severe damage to the brain and may lead to cerebral hemorrhage transformation. p38-mitogen-activated protein kinase (p38mapk) has been implicated in the etiology of a number of diseases because it is a cause of inflammation, but comparatively little research has been carried out into its role in the ... more

Y.Q. Song; H.L. Zou; Y.J. Zhao; L.Q. Yu; Z.X. Tan; R. Kong; Y.Q. Song; H.L. Zou; Y.J. Zhao; L.Q. Yu; Z.X. Tan; R. Kong
09/25/2015
Apoptosis; Caspase 3; Lipid-associated membrane proteins; Mycoplasma hyopneumoniae

Lipid-associated membrane proteins (LAMPs) are important in the pathogenicity of the Mycoplasma genus of bacteria. We investigated whether Mycoplasma hyopneumoniae LAMPs have pathogenic potential by inducing apoptosis in a St. Jude porcine lung epithelial cell line (SJPL). LAMPs from a pathogenic strain of M. hyopneumoniae (strain 232) were used in the research. Our ... more

B. Ni; F.F. Bai; Y. Wei; M.J. Liu; Z.X. Feng; Q.Y. Xiong; L.Z. Hua; G.Q. Shao
09/09/2015
Apoptosis; Liver cirrhosis; Macrophage; Renal injury; Xiayuxue decoction

Renal pathological changes in cirrhotic rat have not been extensively reported. The aim of this study was to investigate whether Xiayuxue decoction (XYXD) could attenuate renal injury induced by bile duct ligation (BDL), with special focus on the mechanisms promoting renal macrophage apoptosis. The rats were treated with BDL for 5 weeks and administered 0.36 g/kg XYXD intragastrically from day ... more

C. Liu; J. Cai; Z. Cheng; X. Dai; L. Tao; J. Zhang; D. Xue
09/08/2015
A431 cells; Apoptosis; Bcl-2; Berberine; Proliferation; Squamous cell carcinoma

Berberine (BBR) is a natural alkaloid with significant anti-tumor activity against many types of cancer cells. In this study, we investigated the molecular mechanisms employed by BBR to repress the proliferation and growth of skin squamous cell carcinoma A431 cells. Berberine was reported to inhibit the proliferation of A431 cells in a dose- and time-dependent manner and was observed to induce ... more

D.X. Li; J. Zhang; Y. Zhang; P.W. Zhao; L.M. Yang
08/10/2015
Acute cerebral infarction; Apoptosis; Baculovirus P35 protein

We explored the effect of baculovirus P35 protein on apoptosis in the brain tissue of rats with acute cerebral infarction (ACI). A rat model of middle cerebral artery infarction was created. The rats were randomly divided into sham, model, and treatment groups. Baculovirus P35 protein was injected into the intracranial arteries of the treatment group rats. The rats in the model group were ... more

J.F. Ji; X.H. Ma
08/14/2015
5-aminolevulinic acid; Apoptosis; Sonodynamic therapy; UMR-106 cells

We investigated the killing effect of low-intensity ultrasound combined with 5-aminolevulinic acid (5-ALA) on the rat osteosarcoma cell line UMR-106. Logarithmic-phase UMR-106 cells were divided into a control group, ultrasound group and 5-ALA group. The cell apoptotic rate, production of reactive oxygen species, and the change in mitochondrial membrane potential were analyzed by flow ... more

Y.N. Li; Q. Zhou; B. Yang; Z. Hu; J.H. Wang; Q.S. Li; W.W. Cao

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