Research Article

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10/09/2015
Chicken; Function annotation; miRNA-1757; Polymorphisms; Target gene

Single nucleotide polymorphism in microRNAs (miRNA) may influence their target gene selection and regulation efficiency, leading to animal phenotypic variation. The aim of this study was to evaluate the possible effect of single nucleotide polymorphisms in the miRNA-1757 gene precursor region (pre-mir-1757) on economic-related traits in chicken. Genotyping was performed using ... more

H. Li; K.R. Jiang; S.H. Wang; X.J. Liu; X.T. Kang; R.R. Jiang; Z.J. Li; G.R. Sun
03/04/2016
Atherothrombosis; Matrix metalloproteinase; Myocardial infarction; Polymorphisms

Several studies have demonstrated that matrix metalloproteinases (MMPs) play a major role in atherosclerotic plaque disruption and lead to myocardial infarction (MI). We investigated the association between the MMP1 -1607 1G/2G (rs1799750), MMP3 -1612 5A/6A (rs3025058), and MMP9 -1562 C/T (rs3918242) polymorphisms and the risk of developing MI in a ... more

J.M. Rodríguez-Pérez; G. Vargas-Alarcón; R. Posadas-Sánchez; T.X. Zagal-Jiménez; R. Ortíz-Alarcón; B. Valente-Acosta; C. Tovilla-Zárate; C. Nostroza-Hernández; O. Pérez-Méndez; N. Pérez-Hernández; J.M. Rodríguez-Pérez; G. Vargas-Alarcón; R. Posadas-Sánchez; T.X. Zagal-Jiménez; R. Ortíz-Alarcón; B. Valente-Acosta; C. Tovilla-Zárate; C. Nostroza-Hernández; O. Pérez-Méndez; N. Pérez-Hernández
11/29/2017
Idiopathic Recurrent Pregnancy Loss SNP genotyping; Polymorphisms; Protein Z gene
Background: Protein Z (PZ) is a vitamin K-dependent
plasma glycoprotein, it plays a key role in the physiologic inhibition
of coagulation by acting as a cofactor in the inactivation of factor Xa.
The relationship between PZ gene polymorphisms and pregnancy
loss is controversial. To address this, we investigate the association
between PZ ... more
W. Zammiti; S. Saidi; A. Shaman; F.Mohammed A. Duhier
11/30/2020
Adult-onset T1DM; Case-control study; Childhood-onset T1DM; IL-18; Polymorphisms; PTPN22

Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the destruction of pancreatic β-cells. Interleukins such as interleukin 18 (IL-18) and protein tyrosine phosphatase, nonreceptor type 22 (PTPN22) have been found to be associated with immune related diseases. We investigated a possible association of polymorphisms in IL-18 gene rs1946518 and ... more

L.P. Campos; V. Graciolo; M. Welter; M.S. Lopes; S. Nesi-França; G. Picheth; F.G.M. Rego
01/31/2022
Brazilian population; Genetic epidemiology; Genetic susceptibility; Polymorphisms; Type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) is a chronic, complex, multifactorial and polygenic disease, constituting one of the greatest public health challenges worldwide. The genetic background has been shown to strongly influence the disease’s susceptibility. We performed genetic screening of risk-variants for T2DM and complications in the Brazilian population. This ... more

J.S. Campos; K.F. Santos; C.C.P. Costa; J.B.S. Barros; V.S.S. Gonçalves; L.P. Assunção; A.A.S. Reis; R.S. Santos
01/18/2023
C677T; Colorectal cancer; Folate metabolism; Methylation; MTHFR; Polymorphisms

We evaluated methylenetetrahydrofolate reductase gene C677T polymorphisms in patients with colorectal cancer in a population-based case-control study in the Azerbaijan population. Genomic DNA was isolated from blood samples taken from 155 patients with colorectal cancer and 155 healthy individuals. The MTHFR gene C677T polymorphism was detected on agarose ... more

H. Aslanov; R. Agaev; B. Bayramov; A. Hadizade; N. Alakbarova; S. Abdulrahimli; V. Yagublu
02/01/2023
Meta-analysis; Neurodegenerative diseases; Polymorphisms; Systematic review; VEGF-A

Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are degenerative scleroses with unclear etiology. Vascular endothelial growth factor A (VEGF-A) is a growth factor that plays multiple roles in the central nervous system.  Previous studies indicated a potential association between polymorphisms in this gene and the susceptibility of ALS and ... more

J.O. Costa; C.C.P. Costa; N.S. Lima; K.F. Santos; A.A.S. Reis; R.S. Santos
02/01/2023
Meta-analysis; Neurodegenerative diseases; One-carbon metabolism; Polymorphisms; Systematic review

The folate cycle is a biochemical pathway that plays an important role in the development and maintenance of the nervous system. Biocompounds synthesized in this cycle must be carefully regulated, since the accumulation of some substances can be neurotoxic and increase susceptibility to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and ... more

J.V.A. Neves; N.S. Lima; C.C.P. Costa; K.F. Santos; A.A.S. Reis; R.S. Santos
12/11/2015
Bone tumor; CYP1A1; Genetic susceptibility; Genotype; GSTM1

Tumor gene polymorphisms are often associated with individual susceptibility to genetic diseases. Cytochrome P4501A1 (CYP1A1) and glutathione S-transferase mu 1 (GSTM1) gene polymorphisms are closely related to the susceptibility of the body to chemical carcinogens in the environment. Therefore, we explored the relationship between CYP1A1 and GSTM1 gene ... more

L. Li; J.G. Li; C.Y. Liu; Y.J. Ding
01/29/2016
Colorectal carcinoma; GSTM1; Polymorphism

The enzyme glutathione S-transferase Mu 1 (GSTM1) is encoded by the GSTM1 gene. Polymorphisms in GSTM1 affect the detoxifying function of the enzyme variants. This forms the basis of the debate about the impact of the GSTM1 null/present genotype on colorectal carcinoma risk. We tested the potential influence of GSTM1 polymorphisms on the development of ... more

M.N. Khabaz; T. Nedjadi; M.A. Gari; J.A. Al-Maghrabi; H.M. Atta; M. Bakarman; Z.J. Gazzaz; M.N. Khabaz; T. Nedjadi; M.A. Gari; J.A. Al-Maghrabi; H.M. Atta; M. Bakarman; Z.J. Gazzaz; M.N. Khabaz; T. Nedjadi; M.A. Gari; J.A. Al-Maghrabi; H.M. Atta; M. Bakarman; Z.J. Gazzaz

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