Research Article

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05/31/2020
Atherosclerosis; eNOS T786C; Nitric oxide; Polymorphism; Stent

Atherosclerosis is a multifactorial chronic-inflammatory disease related to endothelial aggression to the intima layer of medium and large caliber arteries. Hyperlipidemia and atherosclerosis cause eNOS to lose its function, producing superoxide and leading to endothelial dysfunction. The nitric oxide derived from eNOS is anti-atherogenic. Single ... more

A.M. Barbosa; O.S.Dias Neto; K.S.Freitas e Silva; I.B. Lima; U.S. Vilarinho; L.C.A. Gianotti; F.O. de Souza; I.R. da Costa; K.K.V.O. Moura
07/07/2014
Angioplasty; Angioplasty complication; Carotid stenosis; Stent

This study aimed to investigate the clinical effects and safety review of self-expanding stent surgery in the treatment of extracranial carotid artery stenosis. Seventy-eight patients with carotid artery stenosis were applied with the self-expanding stent for endovascular interventional therapy. Eighty-one stents were implanted into 80 blood vessels of the 78 patients, in which ... more

Q.F. Zhu; S.Z. Fang; G.F. Wang; Z.Z. Zhou; S.C. Bian; S.D. Cui; S.B. Yu; F.W. Wang; L.B. Shan; J. Kang
10/05/2016
Proliferating cell nuclear antigen; Restenosis; Vein graft

Neo-intima development and atherosclerosis limit the long-term use of vein grafts for revascularization of ischemic tissues. Recently, studies have confirmed that proliferating cell nuclear antigen (PCNA) plays an important role in cell proliferation. Our research confirmed that 28 days after vein transplantation, PCNA expression increases significantly. Using rabbits, rather than rodents ... more

L. Wan; S.H. Dai; S.Q. Lai; L.Q. Liu; Q. Wang; H. Xu; W.J. Wang; J.C. Liu; L. Wan; S.H. Dai; S.Q. Lai; L.Q. Liu; Q. Wang; H. Xu; W.J. Wang; J.C. Liu
07/14/2015
4-dien-1-one (GBOT); 4-Dihydroxy-phenyl)-1-piperidin-1-yl-penta-2; 5-(3; Atherosclerosis; Blood glucose; Blood lipid metabolism

We observed the variation in in vivo blood lipid and blood glucose metabolism in rats with atherosclerosis after 5-(3,4-dihydroxy-phenyl)-1-piperidin-1-yl-penta-2,4-dien-1-one (GBOT) administration. Wistar rats aged 10 weeks received a high-fat diet to establish the atherosclerosis model. Metabolic indices related to blood lipid and blood glucose were measured before modeling ... more

A. Rong; G. Borjihan; Y.J. Qiao
02/22/2016
Atherosclerosis; Interleukin-4; M2 macrophage; MAPK signaling pathway

Our study aimed to investigate the effects of interleukin-4 (IL-4) on macrophage polarization, as well as its role in the development of atherosclerosis. Human peripheral blood mononuclear cells (PBMCs) were isolated and randomly divided into 3 groups: control group, ox-LDL group, and ox-LDL + IL-4 groups. The expression of M1/M2 macrophage surface markers such as TNF-α, CD68, and CD206 ... more

X.N. Zhao; Y.N. Li; Y.T. Wang; X.N. Zhao; Y.N. Li; Y.T. Wang
04/04/2016
Atherosclerosis; Bioinformatic analysis; Differentially-expressed genes; Familial hypercholesterolemia; Mechanism

The aim of this study was to identify potential markers of atherosclerosis development in familial hypercholesterolemia (FH) patients. GSE13985 microarray data, generated using blood samples from 5 FH patients and 5 matched controls, was downloaded from the Gene Expression Omnibus. Differentially expressed genes (DEGs) between FH and controls were identified and a protein-protein ... more

H.X. Wang; Y.X. Zhao; H.X. Wang; Y.X. Zhao; H.X. Wang; Y.X. Zhao
05/13/2016
Artery plaque; Atherosclerosis; IL-37; Macrophage polarity

As an anti-inflammatory cytokine, interleukin-37 (IL-37) provides certain protective effects against inflammatory and autoimmune diseases. Recent reports indicate that IL-37 is expressed in foam cells of atherosclerotic plaques in both the coronary and carotid arteries of humans, suggesting the possible involvement of IL-37 in the pathogenesis and progression of atherosclerosis. Current ... more

J. Huang; F.L. Hou; A.Y. Zhang; Z.L. Li; J. Huang; F.L. Hou; A.Y. Zhang; Z.L. Li
03/15/2017
Atherosclerosis; Female; Genetic association studies; Genetic predisposition to disease; Genotype; Glutathione transferase; Humans; male; Middle Aged; Polymorphism, Genetic; Risk factors; Smoking

Atherosclerosis is characterized by lesions, called atheroma or atheromatous plaques, in the inner layer of blood vessels, which block the vascular lumen and weaken the underlying tunica media. Several modifiable and non-modifiable risk factors for the development of atherosclerosis exist. The modifiable risk factors include hypertension, smoking, obesity, high LDL and low HDL cholesterol ... more

D.A. Rodrigues; J.V.M. Martins; K.S.F.E. Silva; I.R. Costa; M.H. Lagares; F.L. Campedelli; A.M. Barbosa; M.P. de Morais; K.K.V.O. Moura
05/04/2017
Atherosclerosis; Case-control studies; Female; Genotype; Heterozygote; Humans; male; Middle Aged; Mutation, Missense; Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide

Atherosclerotic and its cardiovascular complications are responsible for 17.5 million deaths a year, according to the World Health Organization. There is consensus that atherosclerosis involves multiple pathogenic processes initiated by endothelial dysfunction, with inflammation and vascular proliferation determining alterations in the matrix, with consequent formation of the atheromatous ... more

F.L. Campedelli; K.S.F.E. Silva; D.A. Rodrigues; J.V.M. Martins; I.R. Costa; M.H. Lagares; A.M. Barbosa; M.P. de Morais; K.K.V.O. Moura
07/06/2017
Atherosclerosis; Case-control studies; Female; Glutathione transferase; Humans; male; Middle Aged; Polymorphism, Genetic

Atherosclerosis is a chronic inflammatory disease formed by the accumulation of lipids in the innermost layer and large-caliber artery (tunica intima). This accumulation, along with platelet factors, stimulates the proliferation of muscle cells in this region. Over than 400 genes may be related to the pathology since they regulate endothelial function, coagulation, inflammation, metabolism of ... more

J.V.M. Martins; D.A. Rodrigues; K.S.F. Silva; I.R. Costa; M.H. Lagares; F.L. Campedelli; A.M. Barbosa; M.P. Morais; K.K.V.O. Moura

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