Research Article

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Bioinformatics tools; Collaborative HIV database; HIV database; HIV/AIDS; Relational database; Resistance and subtype algorithms

We developed a database system for collaborative HIV analysis (DBCollHIV) in Brazil. The main purpose of our DBCollHIV project was to develop an HIV-integrated database system with analytical bioinformatics tools that would support the needs of Brazilian research groups for data storage and sequence analysis. Whenever authorized by the principal investigator, this system also allows ... more

L.V. Araújo; M.A. Soares; S.M. Oliveira; P. Chequer; A. Tanuri; E.C. Sabino; J.E. Ferreira
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Breast cancer; Chinese women; Exome sequencing; SPOP gene

SPOP protein has been found to have ubiquitin ligase activity. Mutations in SPOP gene have been recently reported in some cancers such as prostate, gastric, colorectal cancer. We investigated SPOP DNA mutation in tumor tissues collected from 70 Chinese female breast cancer patients in Southwestern China by DNA sequencing. The results did not show mutation in our tissue samples, indicating ... more

M.A. Khan; L. Zhu; M. Tania; X.L. Xiao; J.J. Fu
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Body mass index; Exome sequencing; Gene; Obesity; Thailand; Variants

Obesity is a major worldwide health issue, with increasing prevalence in adults and children from developed and developing countries. Obesity causes several chronic diseases, including cardiovascular and respiratory diseases, osteoarthritis, hypertension, stroke, type II diabetes, obstructive sleep apnea, and several types of cancer. Previous genome-wide association studies have ... more

S. Kaewsutthi; J. Santiprabhob; B. Phonrat; A. Tungtrongchitr; P. Lertrit; R. Tungtrongchitr
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Body mass index; Exome sequencing; Gene; Obesity; Thailand; Variants

Obesity is a major worldwide health issue, with increasing prevalence in adults and children from developed and developing countries. Obesity causes several chronic diseases, including cardiovascular and respiratory diseases, osteoarthritis, hypertension, stroke, type II diabetes, obstructive sleep apnea, and several types of cancer. Previous genome-wide association studies have ... more

S. Kaewsutthi; J. Santiprabhob; B. Phonrat; A. Tungtrongchitr; P. Lertrit; R. Tungtrongchitr; S. Kaewsutthi; J. Santiprabhob; B. Phonrat; A. Tungtrongchitr; P. Lertrit; R. Tungtrongchitr
01/05/2018
Exome sequencing; Gitelman syndrome; Saudi family; SLC12A3 gene

Gitelman syndrome (GS) is a genetic disorder that affects kidney and causes an imbalance of charged atoms (ions) in the body, including ions of potassium, magnesium, and calcium. GS is characterized by hypokalemia and metabolic alkalosis. GS is a rare autosomal recessive renal tubulopathy disease caused by loss-of-function mutations in the SLC12A3 gene. Objective ... more

M.Imran Naseer; O.Yousef Muthaffar; M. Rasool; A. Abdulkareem; M.Alam Jafri; P.Natesan Pushparaj; G. Kalamegam; A.G. Chaudhary; M.H.Al Qahtani
03/04/2016
Foliar disease; INA phenotype; Phytopathogenic bacteria; Variability

Maize White Spot (MWS), a foliar disease caused by Pantoea ananatis, could cause up to 60% yield loss. Some strains of P. ananatis harboring the ice nucleation gene inaA catalyze the formation of ice nuclei, causing tissue damage at temperatures slightly below freezing. Little is known about the relationship between the presence of the ina gene ... more

A.M. Miller; J.E.F. Figueiredo; G.A. Linde; N.B. Colauto; L.D. Paccola-Meirelles; A.M. Miller; J.E.F. Figueiredo; G.A. Linde; N.B. Colauto; L.D. Paccola-Meirelles
02/26/2018
Germplasm; Pepper; Plant breeding; Variability

Genetic variability among pepper genotypes is essential in obtaining hybrid combinations with greater heterotic effect and in obtaining superior strains. This work’s goal was to evaluate the genetic diversity between accessions of Capsicum annuum L., indicating the selection of promising individuals for ornamental purposes. The experiment was carried out in at the ... more

A.Maria dos Pessoa; E.Ramalho do Rêgo; M.Gonçalves de Carvalho; C.Agrine Per Santos; M.Monteiro d Rêgo
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Bean plant; genetic breeding; Molecular marker ISSR; Variability

The common bean (Phaseolus vulgaris) is a widespread crop in Brazil of dietary and economic importance, and it is cultivated primarily through family farming. Knowledge of genetic variability in landraces and improved bean cultivars is essential to explore the existing diversity, identify superior genotypes adapted to the climatic conditions of specific ... more

P.D.S. Cabral; L.C. de Souza; G.F. da Costa; F.H.L. Silva; T.C.B. Soares
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Brazilian fruit; Conservation; Germplasm; Hancornia speciosa; SSR; Variability

The mangaba, Hancornia speciosa, (Apocynaceae) is a fruit tree native to Brazil with predominantly extractivist production. The fruit can be consumed in natura; however, it is widely consumed as frozen pulp and ice cream produced by agro-industry companies. We evaluated the genetic diversity of 213 individuals that make up the mangaba GeneBank of ... more

A.V.C. Silva; M.F. Vitória; V.R.R. Azevedo; A.J. Sá; A.L.S. Nascimento; M.N. Cardoso; A.N.R. Soares; J.F.Silva Júnior1; A.S. Lédo
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Breeding programs; Legumes; Molecular markers; Variability

Genetic diversity is the basis for genetic improvement as it can provide the basis for new cultivars. Stylosanthes scabra is a grasslands legume that presents potential economic importance in tropical and subtropical regions. Plants of the genus Stylosanthes naturally occur in semiarid native pastures in northeastern Brazil and are highly favored ... more

J.C. Costa; G.G.M. Fracetto; F.J.C. Fracetto; T.C. Souza; M.V.F. Santos; M.A.Lira Junior

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