Research Article

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04/30/2019
Breast cancer; Genetic polymorphism; HLA-G; Saudi Arabia

Human leukocyte antigen-G (HLA-G) has been associated with various immune diseases, including malignancies. The 14-base pair (bp) insertion/deletion (indel) polymorphism (rs16375) in exon 8 of the 3′ untranslated region (3′ UTR) of the HLA-G gene has been reported to influence HLA-G protein expression. We investigated the relationship between the 14-bp indel ... more

S.Y.Al Omar; L. Mansour
06/17/2019
Colorectal cancer; Genetic association; HLA-G; Immune tolerance; Saudi Arabia

Human leukocyte antigen (HLA) G, a non-classical HLA class I (MHC class I) molecule, is characterized by a low degree of polymorphism, unlike classical MHC-I. The 14-base pair insertion/deletion (indel) polymorphism (rs16375) in exon 8 of the 3′ untranslated region has been reported to control HLA-G expression transcriptionally and ... more

A. Hassan; A. Omar; H. Halawani; M. Arafah; S. Alqadheeb; J. Al-Tamimi; L. Mansour
10/30/2015
Colorectal cancer; Genetic polymorphism; HIV-1 infection; Leprosy; NLRP3; Rheumatoid arthritis

Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane Library, PubMed, Embase ... more

Q. Zhang; H.W. Fan; J.Z. Zhang; Y.M. Wang; H.J. Xing
10/02/2015
Asteraceae; Echinops abuzinadianus; Endemic species; Internal transcribed spacer; Saudi Arabia

The present study explored the systematic inventory of Echinops L. (Asteraceae) of Saudi Arabia, with special reference to the molecular typing of Echinops abuzinadianus Chaudhary, an endemic species to Saudi Arabia, based on the internal transcribed spacer (ITS) sequences (ITS1-5.8S-ITS2) of nuclear ribosomal DNA. A sequence similarity search using BLAST and a ... more

M.A. Ali; F.M. Al-Hemaid; J. Lee; A.A. Hatamleh; G. Gyulai; M.O. Rahman
02/16/2017
Adult; Aged; Aged, 80 and over; Arabs; Colorectal neoplasms; Exons; Female; Humans; male; Middle Aged; Mutation; Mutation Rate; Prognosis; Proto-Oncogene Proteins p21(ras); Retrospective Studies; Saudi Arabia; Survival analysis; Young Adult

Mutations in codons 12/13 of K-ras exon 2 are associated with reduced benefit from anti-epidermal growth factor receptor antibody treatment for metastatic colorectal cancer (CRC). Here, we evaluated the frequency of K-ras mutations and their relationship with clinicopathological features and treatment outcomes in Saudi Arabian patients with CRC. The genetic status of K-ras was determined in ... more

J. Zekri; A. Al-Shehri; M. Mahrous; S. Al-Rehaily; T. Darwish; S. Bassi; E. Taani; A. Zahrani; S. Elsamany; J. Al-Maghrabi; B.B. Sadiq
06/20/2017
Antifungal Agents; Bacteria; Bacterial Proteins; Biodiversity; Biotechnology; DNA, Ribosomal; Endophytes; Genetic variation; Hydrolases; Rhizosphere; Saudi Arabia; Seawater; Wetlands

Marine bacteria have been exceptional sources of halotolerant enzymes since decades. The aim of the present study was to isolate bacteria producing hydrolytic enzymes from seven different mangroves collected from the coastal area of Thuwal, Jeddah, Saudi Arabia, and to further screen them for other enzymatic and antifungal activities. We have isolated 46 different rhizo- and endophytic ... more

F. Bibi; I. Ullah; S.A. Alvi; S.A. Bakhsh; M. Yasir; A.A.K. Al-Ghamdi; E.I. Azhar
10/21/2017
FVL; MTHFR; PTH; RSM; Saudi Arabia
Maternally inherited thrombophilia could be one of the causes of recurrent spontaneous miscarriage (RSM). We aimed to investigate the frequency of three thrombotic gene variants; factor V Leiden (FVL; G1691A), prothrombin (PTH; G20210A), and methylenetetrahydrofolate reductase (MTHFR; C677T) in Saudi patients diagnosed with RSM. A case control study was conducted ... more
F. Eldeen; A. Badawy; A. AlSel; M.S. Fawzy
06/30/2019
Gene polymorphisms; HFE; Lead exposure; PON1; Saudi Arabia

Serum paraoxonase (PON1) and hemochromatosis (HFE) genes may play important roles in lead toxicity owing to their role in xenobiotic and iron metabolism, respectively. The association between PON1 and HFE genotypes and blood lead levels (BLLs) was examined in lead exposed subjects from Saudi Arabia. The polymorphisms at PON1 L55M, PON1 Q192R, HFE H63D and HFE C282Y ... more

A.P. Shaik; A.H. Alsaeed; M. Faiyaz-ul-Haque; M.A. Alsaeed; A.S. Shaik
07/04/2019
IL-10; Polycystic ovary syndrome (PCOS); Saudi Arabia; TNF-α gene polymorphism

Polycystic ovarian syndrome (PCOS) is the most prevalent endocrine disorder affecting females. It is a common cause of menstrual irregularities and infertility during a woman’s reproductive years. Many factors may play a crucial role in the pathogenesis of POCS. One of these factors is related to immunogenetics. Cytokines are significant immunomodulatory proteins ... more

A.F. Alkhuriji; S.Y.Al Omar; Z.A. Babay; M.F. El-khadragy; W.G. Allharbi; A.A. Alnafjan
07/13/2015
Colorectal cancer; Epithelial cell adhesion molecule; Immunohistochemistry

We investigated the relationship between the expression of epithelial cell adhesion molecule (EpCAM) and the occurrence and development of colon cancer. Fifty colon cancer tissues and adjacent normal tissues were collected, while 40 normal intestinal mucosa tissues were collected as the blank group. EpCAM expression was detected by immunohistochemistry and the patients were followed-up to ... more

X.B. Chai; R.F. Song; F. Xu

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