Research Article

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01/30/2015
Blood occlusion; Hippocampus; Hypothermia; Ultrastructure; Vimentin

Previous studies have shown that selective cerebral profound hypothermia combined with antegrade cerebral perfusion can improve resistance to cerebral hypoxia-ischemia in monkeys. The aim of this study was to observe the effect of selective cerebral profound hypothermia on the ultrastructure and vimentin expression in monkey hippocampi after severe cerebral ischemia. Eight healthy adult ... more

B.C. Li; X. Fu; X.Q. Niu; Y.D. Fan; W. Xu; X.X. Zhao; J. Pu
02/23/2017
Blotting, Western; Cadherins; Cell Movement; Cell proliferation; Cell survival; Female; Gene Expression Regulation, Neoplastic; Hela cells; Humans; MicroRNAs; Neoplasm Metastasis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Long Noncoding; Uterine cervical neoplasms; Vimentin

Cervical cancer is a common female malignancy of global dimensions. MicroRNAs (miRNAs) play crucial roles in the development, differentiation, proliferation, and apoptosis of tumors. The non-coding RNA MALAT1 participates in various physiological processes that are important for proper functioning of the body. Here, we analyzed the expression of miRNA-143 and MALAT1 in HeLa cells to evaluate ... more

L. Zhang; H.E.X.D. Niyazi; H.R. Zhao; X.P. Cao; M.N.S. Abudula; W.J. Ye; S.A. Zhang; R.H.M. Yiming; Y. Zhang; W.P. Su; R. Chen; Y. Ouyang; N. Miao; Y.X. Bao
09/02/2016
Biliary atresia; Epithelial-mesenchymal transition; miR-129-5p; MiR-29c

Biliary atresia (BA) is a destructive bile duct disease occurring in newborn children within a few weeks after birth. In this study, the effect of miR-29c and miR-129-5p on epithelial-mesenchymal transition (EMT) in experimental BA was explored by constructing BA mouse models via Rhesus rotavirus vaccine infection. miR-29c and miR-129-5p expression was analyzed by real-time quantitative ... more

J.Y. Wang; Z.H. Li; M. Ye; Q. Feng; Z.M. Chen; X.S. Ye; Z.G. Wu; B. Wang; L. Liu; J. Yao; J.Y. Wang; Z.H. Li; M. Ye; Q. Feng; Z.M. Chen; X.S. Ye; Z.G. Wu; B. Wang; L. Liu; J. Yao
08/29/2016
Cancer stem cell; Epithelial-mesenchymal transition; Gastric carcinoma; Snail

Biological changes in Snail-overexpressed SGC7901 cells were studied by establishing a pEGFP-C1-Snail carrier. The significance of Snail in epithelial-mesenchymal transition (EMT) as well as the invasion and metastatic capacity of gastric cancer cells was also discussed; moreover, we attempted to verify the probable cancer stem cell characteristics of Snail-overexpressed cells. A pEGFP-C1 ... more

Y.J. Yang; Z.B. Li; G.R. Zhang; L.J. Wu; J.Y. Yu; L.J. Hu; Y.L. Zhou; H.D. Wang; D. Liang; Y.J. Yang; Z.B. Li; G.R. Zhang; L.J. Wu; J.Y. Yu; L.J. Hu; Y.L. Zhou; H.D. Wang; D. Liang
09/09/2015
Global cerebral ischemia-reperfusion; Immunohistochemistry; Intermittent hypobaric hypoxia

This study was aimed at understanding the effect of intermittent hypobaric hypoxia preconditioning (IHHP) on neuroglobin (NGB) and Bcl-2 expression in the hippocampal CA1 region of rats following global cerebral ischemia-reperfusion. Wistar rats were randomly divided into sham, IHHP control, global cerebral ischemia-reperfusion (IR group), and IHHP+IR groups. The four-vessel occlusion rat ... more

Q. Wu; K.X. Yu; Q.S. Ma; Y.N. Liu
07/13/2015
Colorectal cancer; Epithelial cell adhesion molecule; Immunohistochemistry

We investigated the relationship between the expression of epithelial cell adhesion molecule (EpCAM) and the occurrence and development of colon cancer. Fifty colon cancer tissues and adjacent normal tissues were collected, while 40 normal intestinal mucosa tissues were collected as the blank group. EpCAM expression was detected by immunohistochemistry and the patients were followed-up to ... more

X.B. Chai; R.F. Song; F. Xu
12/29/2015
ELISA; Immunohistochemistry; Polyclonal antibody; Porcine β-defensin 2; Western blotting

Porcine β-defensin 2 (pBD2) is an antimicrobial peptide in pigs that plays an important role in the immune system by preventing bacterial invasion. To produce an anti-pBD2 antibody, which is not commercially available, we expressed and purified a soluble, his-tagged version of pBD2 (his-pBD2). Purified pBD2 was injected into New Zealand white rabbits to generate polyclonal antiserum. Anti ... more

Y.Y. Bao; L. Li; H. Zhang; C.Y. Gao; C.B. Xiao; C.L. Li
12/22/2015
Expression profile; GAS6; Immunohistochemistry; Pig; SNP

The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. A recent report has demonstrated that the GAS6 gene can promote fat deposition and is associated with an increased number of fat cells in mice. In order to investigate ... more

D. Xu; J. Jiang; J. He; C.Q. He; H.M. Ma
12/08/2015
Immunohistochemistry; Magnetic resonance perfusion weighted imaging; Radiation-induced brain injury; Vascular endothelial growth factor

We used magnetic resonance perfusion weighted imaging and pathological evaluation to examine different stages of radiation-induced brain injury and to investigate the correlation between the relative cerebral blood volume (rCBV) ratio and vascular endothelial growth factor (VEGF). Thirty adult rats were randomly divided into 2 groups: control and radiation group. The control group was not ... more

X.J. Liu; C.F. Duan; W.W. Fu; L. Niu; Y. Li; Q.L. Sui; W.J. Xu
11/30/2015
c-Myc; Carcinoma papillary; Immunohistochemistry; Mucin 1; Proto-oncogene proteins; Thyroid

The aim of this study was to examine the expression of mucin 1 (MUC1) and c-myc and the significance thereof in elderly patients with papillary thyroid carcinoma. The expression levels of MUC1 and c-myc were examined by immunohistochemical methods in 58 patients with papillary thyroid carcinoma, 35 with nodular goiter, and 30 subjects with normal thyroid tissue. The positive rate of MUC1 ... more

Y.J. Hu; X.Y. Luo; Y. Yang; C.Y. Chen; Z.Y. Zhang; X. Guo

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