Research Article

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The angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been reported to be associated with digestive system cancer; however, the results from previous studies have been conflicting. The present study aimed to investigate the association between the ACE I/D polymorphism and the risk of digestive system cancer using a meta-analysis of ... more

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Colorectal cancer; Genetic polymorphism; HIV-1 infection; Leprosy; NLRP3; Rheumatoid arthritis

Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane Library, PubMed, Embase ... more

Q. Zhang; H.W. Fan; J.Z. Zhang; Y.M. Wang; H.J. Xing
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Genetic polymorphism; Interleukin-1 gene; Meta-analysis; Periodontitis

Genetic variations in human interleukin-1 (IL-1) genes are known to be involved in inflammatory disorders. The rs17561 and rs1143634 polymorphisms of IL-1α and IL-1β, respectively, have been increasingly recognized as important regulators in the development of periodontitis. However, the existence of a specific association remains controversial. Therefore, we ... more

W.T. Yin; Y.P. Pan; L. Lin; W.T. Yin; Y.P. Pan; L. Lin
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Arterial hypertension; Blood pressure; Genetic polymorphism; Polymorphic Aluyb8; WNK1

WNK1 (With No-lysine Kinase 1), a serine-threonine kinase, regulates blood pressure by acting on various sodium transport-related ion channels. Several studies report a link between common variants of the WNK1 gene and hypertension. No data exists on Russian populations. Our aim was to evaluate the association between the WNK1 AluYb8 polymorphism and hypertension ... more

E. Akhmedova; S.Y. Nikulina; A.B. Salmina; A. Chernova; M. Bazanova; A. Ohapkina; A. Semenchukov; P.E. Maltese; E. Manara; M. Bertelli
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Bulgarian Rhodopean cattle; Genetic polymorphism; Milk proteins; αS1 - casein

Milk protein genetic polymorphisms of the genus Bos provoke a significant scientific interest, mainly associated with their evolution, population structure, breeding and hybridization. The aim of present study is to investigate the influence of the genetic variants of αS1- casein gene with respect to milk production and quality of native for Bulgaria cattle breed ... more

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Breast cancer; Genetic polymorphism; HLA-G; Saudi Arabia

Human leukocyte antigen-G (HLA-G) has been associated with various immune diseases, including malignancies. The 14-base pair (bp) insertion/deletion (indel) polymorphism (rs16375) in exon 8 of the 3′ untranslated region (3′ UTR) of the HLA-G gene has been reported to influence HLA-G protein expression. We investigated the relationship between the 14-bp indel ... more

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Genetic polymorphism; HIV; Interleukin-7 receptor; Limpopo Province; Opportunistic Infections; Single nucleotide polymorphism

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T.C. Nangammbi; G.T. Moloro; A. Samie
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Dyslipidemia; Genetic polymorphism; LDL-cholesterol

The main polymorphisms linked to dyslipidemia include those of the SMARCA4 gene. We evaluated the association between lipidic profile and SMARCA4 gene polymorphism in 200 military police officers. Real time PCR was used to identify SMARCA4 gene polymorphisms. Among the subjects, 116 had dyslipidemia (case group), of which 94% were males, ... more

H.A.G.B. Queiroz; F.S. Castro; A.M.T.C. Silva; C.M. Gomes; S.H.N. Costa; L.C. da Cunha
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CD1 antigen presenting molecules; Colorectal cancer; Genetic polymorphism; Saudi Arabia

Cluster of differentiation 1 (CD1) is antigen-presenting molecule involved in the presentation of lipid and glycolipid antigens to specific T cells and natural killer T cells. They exhibit a low rate of polymorphism compared to classical major histocompatibility complex presenting molecules. In this case control study, we examined a possible association of genetic ... more

S. Alomar; J. Al-Tamimi; T. Almanaa; A. Al-jurayyan; L. Mansour

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