Brief Note

Related GMR Articles

Diabetes mellitus; Genetic susceptibility; Melatonin receptor; MT2; Pregnancy; Single nucleotide polymorphisms

We investigated the association between rs4753426 single nucleotide polymorphisms in the melatonin receptor 1B (MTNR1B) gene and the risk of developing gestational diabetes mellitus (GDM). A total of 516 gravidas (186 with GDM and 330 non-diabetic controls) were enrolled in the study. Genotype and allele frequencies of rs4753426 in the MTNR1B gene were detected by DNA ... more

Y. Zhan; C. Li; Q. Gao; J. Chen; S. Yu; S.G. Liu
Bone tumor; CYP1A1; Genetic susceptibility; Genotype; GSTM1

Tumor gene polymorphisms are often associated with individual susceptibility to genetic diseases. Cytochrome P4501A1 (CYP1A1) and glutathione S-transferase mu 1 (GSTM1) gene polymorphisms are closely related to the susceptibility of the body to chemical carcinogens in the environment. Therefore, we explored the relationship between CYP1A1 and GSTM1 gene ... more

L. Li; J.G. Li; C.Y. Liu; Y.J. Ding
Genetic susceptibility; HLA; Leishmaniasis

Leishmaniasis is a parasitic infectious disease with global repercussions. American cutaneous leishmaniasis (ACL) is endemic in southern Brazil and its pathogenesis varies according to parasite species, immune response, and host genetics. In terms of immunogenetics, many host genes, including HLA (human leukocyte antigen), could be involved in susceptibility to and protection against ACL ... more

R.C. Ribas-Silva; A.D. Ribas; E.C. Ferreira; T.G.V. Silveira; S.D. Borelli
DNMT3B -149C/T polymorphism; Genetic susceptibility; LSCC; Risk

A variety of molecular epidemiological studies have been conducted to examine the association between the DNMT3B -149C/T polymorphism and cancer susceptibility; however, there has been no study investigating the association between the DNMT3B -149C/T polymorphism and the risk of laryngeal squamous cell carcinoma (LSCC) until now. To determine the role of the DNMT3B ... more

X.M. Zhang; S. Li; Q.M. Zhang
-174G>C; Adult-onset T1D; Asp358Ala; Genetic susceptibility; IL6R; Promoter polymorphism

Type 1 Diabetes mellitus (T1D) is caused by the immune-mediated destruction of insulin-producing islet β cells, and its pathogenesis involves cytokines. Genetic background may influence cytokine signals, and polymorphisms may determine their impact on T1D autoimmunity. Several polymorphisms in and close to Interleukin-6 (IL-6) and Interleukin-6 Receptor ( ... more

L.P. Campos; V. Graciolo; M.M. Sousa; B.R. Martins; S.W. Souza; D. Alberton; G. Picheth; F.G.M. Rego
Autoimmune disease; CTLA-4; PTPN22; TNF-α; Type 1 diabetes mellitus

Type 1 diabetes mellitus (T1D) is a complex disorder characterized by an autoimmune response against human pancreatic beta-cells. Patients with T1D can also develop a response toward one or more other factors, such as in autoimmune thyroiditis (AITD) and celiac disease (CD). In the presence of T1D + AITD, the patient is diagnosed with autoimmune polyglandular syndrome type III (APSIII); ... more

N.A.C. Tavares; M.M.S. Santos; R. Moura; J. Araújo; R.L. Guimarães; S. Crovella; L.A.C. Brandão
All-trans retinoic acid; Interferon gamma; Interleukin 4; Type 1 diabetes mellitus

The aim of this study was to explore the molecular mechanism by which all-trans retinoic acid (ATRA) prevents type 1 diabetes mellitus (T1DM). Fifty ICR mice were randomly assigned to three groups: prevention group [N = 20; mice received 10 mg/kg ATRA daily for 5 days and then 60 mg/kg streptozotocin (STZ) for 5 days]; diabetic group (N = 20, mice received 95% sterile peanut oil and 5% ... more

Y. Wang; Y.J. Zhong; Y.Y. Wang; J. Xing; Z.M. Wang; Y. Wang; Y.J. Zhong; Y.Y. Wang; J. Xing; Z.M. Wang; Y. Wang; Y.J. Zhong; Y.Y. Wang; J. Xing; Z.M. Wang
Body measurement traits; Carcass quality traits; SNP; STAT3

Previous studies have shown that the signal transducer and activator of transcription 3 gene (STAT3) is involved in lipid storage and energy metabolism, suggesting that STAT3 is a potential candidate gene that affects body measurement and carcass quality traits in animals. Therefore, the aim of this study was to identify polymorphisms in bovine STAT3 and to ... more

N. Song; L.S. Gui; H.C. Xu; S. Wu; L.S. Zan
CRH; Economic traits; Hanwoo; Korean cattle; POMC; SNP

The corticotrophin-releasing hormone (CRH) and proo­piomelanocortin (POMC) genes are considered to play an important role in the growth and development of mammals. In this study, the bovine CRH and POMC genes were characterized to detect genetic variation at these loci in relation to economic traits in Korean cattle (Hanwoo). Nine single ... more

J. Seong; H.S. Kong
Association study; Schizophrenia; SNP; VRK2 gene

Previous studies have found that the vaccinia related kinase 2 gene (VRK2) polymorphism was associated with schizophrenia (SCZ) in the worldwide population. This association was further supported by VRK2 mRNA expression patterns and brain structure variations. Here, we analyzed four single nucleotide polymorphisms (SNPs) of the VRK2 gene in a total population of 893 ... more

B. Zhang; C.Y. Gao; H.B. Zhang; B. Yang; J.F. Yin; S.G. Wei; Y.S. Zhu; X.N. Jia; S.B. Li