Research Article

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07/03/2015
Benign prostate hyperplasia; Genetic polymorphism; Prostate cancer

We compared single-nucleotide polymorphisms for point mutations in cytochrome P450 genes, including cytochrome P450c17α (CYP17), cytochrome P450 aromatase (CYP19), steroid-5-a-reductase (SRD5A2), and prostate-specific antigen (PSA) involved in androgen and estrogen production. Between January 2008 and January 2010, 90 patients were enrolled in the study. Of ... more

E. Ersekerci; M. Sofikerim; S. Taheri; A. Demirtas; F. Halis
12/16/2015
HER2/neu; Prostate cancer; RNA interference; Small-interfering RNA

The aim of this study was to investigate the effect of a small interfering RNA (siRNA) targeting human epidermal growth factor receptor 2 (HER2/neu) on the proliferation and viability of prostate cancer PC-3M cells. Chemically synthesized siRNA targeting HER2/neu was transfected into PC-3M cells by using liposomes, and cells transfected with empty liposomes, a negative siRNA sequence, or ... more

C.Y. Liu; P.C. Xu; D.G. Chen; X.H. Fan; M.Q. Li; X. Yang; Y.P. Xu
12/02/2015
CapG; Cell growth; Invasion; Metastasis; Prostate cancer; RNA interference

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B.K. Li; K. Guo; C.Y. Li; H.L. Li; P.P. Zhao; K. Chen; C.X. Liu
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CYP17 gene; Polymorphism; Prostate cancer

Cytochrome P450 17a-hydroxylase (CYP17) plays a critical role in androgen biosynthesis. Polymorphisms of the CYP17 promoter have been proposed as risk factors for prostate cancer; however, some studies have produced inconclusive or controversial results. We investigated the relationship between polymorphisms of the CYP17 gene and the risk of prostate cancer. A total of ... more

J. Song; Z.H. Tao; X.Y. Liu; S. Gong; L. Gan; J. Song; Z.H. Tao; X.Y. Liu; S. Gong; L. Gan
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Livin; Nanoparticle; PC-3M; Prostate cancer; RNA interference; Survivin

Monomethoxypolyethylene glycol-chitosan (mPEG-CS) nanoparticles were used as interfering RNA carriers to transfect human prostate cancer PC-3M cells to evaluate the effects of livin and survivin gene silencing on the proliferation and apoptosis. mPEG-CS nanoparticles with sizes of approximately 60 nm were first synthesized by ionic crosslinking. Through electrostatic adsorption, mPEG-CS- ... more

A.Q. Yang; P.J. Wang; T. Huang; W.L. Zhou; J. Landman; A.Q. Yang; P.J. Wang; T. Huang; W.L. Zhou; J. Landman; A.Q. Yang; P.J. Wang; T. Huang; W.L. Zhou; J. Landman
12/11/2015
Bone tumor; CYP1A1; Genetic susceptibility; Genotype; GSTM1

Tumor gene polymorphisms are often associated with individual susceptibility to genetic diseases. Cytochrome P4501A1 (CYP1A1) and glutathione S-transferase mu 1 (GSTM1) gene polymorphisms are closely related to the susceptibility of the body to chemical carcinogens in the environment. Therefore, we explored the relationship between CYP1A1 and GSTM1 gene ... more

L. Li; J.G. Li; C.Y. Liu; Y.J. Ding
01/29/2016
Colorectal carcinoma; GSTM1; Polymorphism

The enzyme glutathione S-transferase Mu 1 (GSTM1) is encoded by the GSTM1 gene. Polymorphisms in GSTM1 affect the detoxifying function of the enzyme variants. This forms the basis of the debate about the impact of the GSTM1 null/present genotype on colorectal carcinoma risk. We tested the potential influence of GSTM1 polymorphisms on the development of ... more

M.N. Khabaz; T. Nedjadi; M.A. Gari; J.A. Al-Maghrabi; H.M. Atta; M. Bakarman; Z.J. Gazzaz; M.N. Khabaz; T. Nedjadi; M.A. Gari; J.A. Al-Maghrabi; H.M. Atta; M. Bakarman; Z.J. Gazzaz; M.N. Khabaz; T. Nedjadi; M.A. Gari; J.A. Al-Maghrabi; H.M. Atta; M. Bakarman; Z.J. Gazzaz
09/25/2015
Coronary artery disease; IL-17A; IL-17F; Polymorphism

A case-control study was conducted to investigate the association between genetic variants of IL-17A rs2275913 and IL-17F rs763780 and the development of coronary artery disease (CAD) in a Chinese population. A total of 306 individuals with CAD and 306 unaffected individuals were enrolled from the Zhengzhou People’s Hospital between May 2012 and May 2014. The IL-17A ... more

G.Y. Geng; H.L. Liu; Y.J. Zhao; L. Wu; L. Mao; N. Ba
09/28/2015
DNA repair genes; Osteosarcoma; Overall survival; Polymorphism

We conducted a perspective study to investigate the role of ERCC1 (rs11615), ERCC2 (rs13181 and rs1799793), ERCC4 (rs1800067), and ERCC5 (rs17655) in NER pathway in the prognosis of osteosarcoma patients. In total, 146 osteosarcoma patients were recruited between 2008 and 2013. ERCC1 rs11615, ERCC2 rs13181 and rs1799793, ERCC4 rs1800067, and ERCC5 rs17655 gene polymorphisms were assessed ... more

M.J. Wang; Y. Zhu; X.J. Guo; Z.Z. Tian
09/22/2015
Chemotherapy; Clinical outcome; Glutathione S-transferases; Polymorphism

The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymor­phisms in the clinical response to chemotherapy and treatment outcome of patients with breast cancer. A total of 262 subjects were randomly selected from among patients with a histologically confirmed breast cancer. The genotypes of GSTM1, ... more

J. Wang; T. Wang; G.Y. Yin; L. Yang; Z.G. Wang; X.B. Bu

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