Research Article

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12/29/2015
GSTM1; GSTT1; Meta-analysis; Polymorphism; Varicocele

The glutathione S-transferase (GST) family represents a major group of detoxification and antioxidant enzymes. Studies have shown that high oxidative stress levels are associated with varicocele. The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patients and 476 ... more

B. Zhu; L. Yin; J.Y. Zhang
04/30/2019
GSTM1; GSTT1; Polymorphism; Prognosis; Sickle cell anemia

Sickle cell anemia is one of the most common genetic diseases in Brazil. This disease has an autosomal recessive inheritance pattern with a point mutation on chromosome 11, which is the substitution of an adenine by thymine. This mutation leads to the exchange of a glutamic acid for a valine at residue 6 of the beta globin chain, resulting in an abnormal form of hemoglobin, the so-called ... more

O.S.Dias Neto; K.S.Fe Silva; A.M. Barbosa; D.A. Rodrigues; M.H. Lagares; I.R. da Costa; K.K.V.O. Moura
02/25/2019
Cervical cancer; GSTM1; GSTT1; Smoking

Human papillomavirus infection is the main risk factor for cervical cancer. Other risk factors include smoking and genetic susceptibility. Glutathione-S-transferases are enzymes involved in tobacco carcinogen metabolism, and genes encoding these enzymes are highly polymorphic. We compared the frequencies of GSTM1 and GSTT1 null polymorphisms in ... more

A.L.M. Tacca; A.K. Lopes; C.A.S.T. Vilanova-Costa; A.M.T.C. Silva; S.H.N. Costa; N.A. Nogueira; J.E.P. Ramos; A.A. Ribeiro; V.A. Saddi
02/25/2019
Atherosclerosis; eNOS; GSTM1; GSTT1; Hypertension

Atherosclerosis is a multifactorial chronic inflammatory disease that occurs in response to endothelial aggression. Systemic arterial hypertension is the main risk factor for the formation of atheromas, increasing the risk of cardiovascular diseases. Several genes are involved in atherogenesis and hypertension. We analyzed polymorphisms of candidate genes that ... more

M.P. Moraes; K.S.Fe Silva; M.H. Lagares; A.M. Barbosa; J.V.M. Martins; F.L. Campedelli; I.R. da Costa; D.A. Rodrigues; K.K.V.O. Moura
12/29/2015
Meta-analysis; Polymorphism; Prostate cancer

Recent studies have indicated that single nucleotide polymorphisms (SNPs) within the 8q24 region may be a risk factor for prostate cancer (PCa). Here, we performed a meta-analysis to evaluate the association between the 8q24 rs6983267 T/G polymorphism and PCa risk. A systematic literature search was carried out in multiple electronic databases independently by two investigators. Pooled ... more

H.S. Zhu; J.F. Zhang; J.D. Zhou; M.J. Zhang; H.X. Hu
06/10/2016
Genetic variant; Lung cancer; Molecular marker; Risk factor; XRCC1

Lung cancer is the most common cancer occurring worldwide. The human X-ray repair complementing group 1 (XRCC1) gene is one of the most important candidate genes that influence the susceptibility to lung cancer. The objective of this study was to analyze the potential association between the c.1804C>A genetic variant of XRCC1 and lung cancer susceptibility. A total of ... more

J.J. Jin; H.Q. Wang; H.P. Kuang; B.B. Kang; Y.H. Liu; J. Wang; J.J. Jin; H.Q. Wang; H.P. Kuang; B.B. Kang; Y.H. Liu; J. Wang
04/28/2016
Chemotherapy; GSTM1; GSTP1 polymorphism; GSTT1; NSCLC

The aim of this study was to evaluate the association of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms with the chemotherapy response and overall survival of advanced NSCLC. Two hundred and sixty-two patients with histologically confirmed advanced NSCLC (inoperable TNM stages IIIA, IIIB, and IV) were enrolled to this hospital-based ... more

H.L. Xiao; Z.T. Yang; F. Han; H.X. Wei; H.L. Xiao; Z.T. Yang; F. Han; H.X. Wei; H.L. Xiao; Z.T. Yang; F. Han; H.X. Wei
07/03/2015
HNF1B rs4430796 (A>G) polymorphism; Meta-analysis; Prostate cancer

Genome-wide studies have reported an association between the HNF1B rs4430796 (A>G) polymorphism and prostate cancer risk, but results have been inconsistent and recent meta-analyses have been inadequate. This study aimed to integrate previous results and explore the validity of this association. Electronic searches for all relevant publications through May 18, 2014, were ... more

Y. Zhao; J. Liang; J.G. Qi; N. Yang; G. Wu; Y.L. Lin; J.Y. Cao; Q. Wang; Q.C. Wang
07/03/2015
Benign prostate hyperplasia; Genetic polymorphism; Prostate cancer

We compared single-nucleotide polymorphisms for point mutations in cytochrome P450 genes, including cytochrome P450c17α (CYP17), cytochrome P450 aromatase (CYP19), steroid-5-a-reductase (SRD5A2), and prostate-specific antigen (PSA) involved in androgen and estrogen production. Between January 2008 and January 2010, 90 patients were enrolled in the study. Of ... more

E. Ersekerci; M. Sofikerim; S. Taheri; A. Demirtas; F. Halis
12/16/2015
HER2/neu; Prostate cancer; RNA interference; Small-interfering RNA

The aim of this study was to investigate the effect of a small interfering RNA (siRNA) targeting human epidermal growth factor receptor 2 (HER2/neu) on the proliferation and viability of prostate cancer PC-3M cells. Chemically synthesized siRNA targeting HER2/neu was transfected into PC-3M cells by using liposomes, and cells transfected with empty liposomes, a negative siRNA sequence, or ... more

C.Y. Liu; P.C. Xu; D.G. Chen; X.H. Fan; M.Q. Li; X. Yang; Y.P. Xu

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