Research Article

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Fertility; Genetic association; Hatchability; Heritability; White leghorn

Studies estimating genetic parameters for reproductive traits in chickens can be useful for understanding and improvement of their genetic architecture. A total of 1276 observations of fertility (FERT), hatchability of fertile eggs (HFE) and hatchability of total eggs (HTE) were used to estimate the genetic and phenotypic parameters of 467 females from an F2 population generated by ... more

R.P. Savegnago; M.E. Buzanskas; B.N. Nunes; S.B. Ramos; M.C. Ledur; K. Nones; D.P. Munari
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Bone mineral density; Bone morphogenetic protein 2 and 4; Genetic association; Osteoporosis; Single-nucleotide polymorphism

We investigated the effect of bone morphogenetic protein 2 and 4 (BMP-2 and -4) gene polymorphisms on bone density in postmenopausal Turkish women with osteoporosis. The frequency of single-nucleotide polymorphisms (SNPs) of BMP-2 and -4 genes was analyzed in 101 osteoporotic-postmenopausal women and 52 postmenopausal women with positive bone mineral density scores. We evaluated the ... more

Z.S. Özkan; D. Deveci; E. Önalan; H. Yüce
04/26/2013
CCND1 gene; Esophageal cancer; Genetic association; Meta-analysis; Polymorphism

The association between the Cyclin D1 gene (CCND1) G870A polymorphism and esophageal cancer has been widely evaluated, with conflicting results. As meta-analysis is a reliable approach to resolving discrepancies, we aimed to evaluate this association. Data were available from 9 study populations incorporating 1898 cases and 3046 controls. Overall, the allelic/genotypic ... more

W. Cai; Z.T. Wang; J. Zhong; Y. Zhang
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Genetic association; Genetic polymorphism; Holstein cows; Molecular markers

The bovine prolactin (PRL) and bovine growth hormone (bGH) genes exhibit several polymorphisms. Some of them can be detected by molecular techniques using restriction endonucleases, such as RsaI for the PRL gene and MspI for the bGH gene. We examined the relationship between the PRL-RsaI and bGH-MspI polymorphisms and ... more

J.C. Rincón; A. López-Herrera; J.J. Echeverri
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BMP-2; COL6A1; Genetic association; Ossification of the posterior longitudinal ligament; Single nucleotide polymorphism

COL6A1 and BMP-2 genes have been implicated in ossification of the posterior longitudinal ligament (OPLL) susceptibility in Japanese and Chinese Han populations. However, no study has yet investigated the DNA of unaffected family members of patients with OPLL. This study investigated differences in genetic polymorphisms of BMP-2 and COL6A1 between Korean patients with ... more

K.H. Kim; S.U. Kuh; J.Y. Park; S.J. Lee; H.S. Park; D.K. Chin; K.S. Kim; Y.E. Cho
06/17/2019
Colorectal cancer; Genetic association; HLA-G; Immune tolerance; Saudi Arabia

Human leukocyte antigen (HLA) G, a non-classical HLA class I (MHC class I) molecule, is characterized by a low degree of polymorphism, unlike classical MHC-I. The 14-base pair insertion/deletion (indel) polymorphism (rs16375) in exon 8 of the 3′ untranslated region has been reported to control HLA-G expression transcriptionally and ... more

A. Hassan; A. Omar; H. Halawani; M. Arafah; S. Alqadheeb; J. Al-Tamimi; L. Mansour
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ACE I/D polymorphism; Diabetic nephropathy; Genetic association; Meta-analysis; Systematic reviews

The angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism could influence predisposition for diabetic nephropathy (DN) by vascular modulation in the kidney, through a direct effect on cellular hypertrophy. However, studies on the association between this polymorphism and DN report conflicting results. To help determine if this association ... more

L.C. Silveira; E.G. da Silva; R.M. Azevedo; L.R.Bdos Anjos; R.F. Chagas; E.C. Alcântara; R.S. Santos; A.A.S. Reis
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Biometric; Selection; SNPs; Statistics

The aim of this study was to evaluate different methods used in genomic selection, and to verify those that select a higher proportion of individuals with superior genotypes. Thus, F2 populations of different sizes were simulated (100, 200, 500, and 1000 individuals) with 10 replications each. These consisted of 10 linkage groups (LG) of 100 cM each, containing 100 equally spaced markers ... more

L.L. Bhering; V.S. Junqueira; L.A. Peixoto; C.D. Cruz; B.G. Laviola
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Idiopathic azoospermia; Idiopathic oligospermia; Pygo2 gene; SNPs

Male infertility is often associated with a decreased sperm count. The Pygo2 gene is expressed in the elongating spermatid during chromatin remodeling; thus impairment in PYGO2 function might lead to spermatogenic arrest, sperm count reduction, and subsequent infertility. The aim of this study was to identify mutations in Pygo2 that might lead to idiopathic oligospermia ... more

S.Q. Ge; J. Grifin; L.H. Liu; K.I. Aston; L. Simon; T.G. Jenkins; B.R. Emery; D.T. Carrell
12/17/2015
Body size; Haplotype; IGFBP-6; Mini-pig; SNPs

Insulin-like growth factor binding protein-6 (IGFBP-6) is a member of the IGFBP family, which is known to be a key factor in regulating the effect of insulin-like growth factor-2 (IGF-2) on the animal growth and development. Gene sequences of 3'-untranslated regions (UTR) and exon 4 of IGFBP-6 may influence the expression and proteolysis of IGFBP-6. In this study, 551 bp of the ... more

X.B. Fang; S.C. Liu; Q.Y. Wu; S.M. Li; Y.Y. Cheng; H.Y. Fu; C. Lu; D. Su; H. Yu; L.L. Hao

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