Research Article

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10/02/2015
Asteraceae; Echinops abuzinadianus; Endemic species; Internal transcribed spacer; Saudi Arabia

The present study explored the systematic inventory of Echinops L. (Asteraceae) of Saudi Arabia, with special reference to the molecular typing of Echinops abuzinadianus Chaudhary, an endemic species to Saudi Arabia, based on the internal transcribed spacer (ITS) sequences (ITS1-5.8S-ITS2) of nuclear ribosomal DNA. A sequence similarity search using BLAST and a ... more

M.A. Ali; F.M. Al-Hemaid; J. Lee; A.A. Hatamleh; G. Gyulai; M.O. Rahman
02/16/2017
Adult; Aged; Aged, 80 and over; Arabs; Colorectal neoplasms; Exons; Female; Humans; male; Middle Aged; Mutation; Mutation Rate; Prognosis; Proto-Oncogene Proteins p21(ras); Retrospective Studies; Saudi Arabia; Survival analysis; Young Adult

Mutations in codons 12/13 of K-ras exon 2 are associated with reduced benefit from anti-epidermal growth factor receptor antibody treatment for metastatic colorectal cancer (CRC). Here, we evaluated the frequency of K-ras mutations and their relationship with clinicopathological features and treatment outcomes in Saudi Arabian patients with CRC. The genetic status of K-ras was determined in ... more

J. Zekri; A. Al-Shehri; M. Mahrous; S. Al-Rehaily; T. Darwish; S. Bassi; E. Taani; A. Zahrani; S. Elsamany; J. Al-Maghrabi; B.B. Sadiq
06/20/2017
Antifungal Agents; Bacteria; Bacterial Proteins; Biodiversity; Biotechnology; DNA, Ribosomal; Endophytes; Genetic variation; Hydrolases; Rhizosphere; Saudi Arabia; Seawater; Wetlands

Marine bacteria have been exceptional sources of halotolerant enzymes since decades. The aim of the present study was to isolate bacteria producing hydrolytic enzymes from seven different mangroves collected from the coastal area of Thuwal, Jeddah, Saudi Arabia, and to further screen them for other enzymatic and antifungal activities. We have isolated 46 different rhizo- and endophytic ... more

F. Bibi; I. Ullah; S.A. Alvi; S.A. Bakhsh; M. Yasir; A.A.K. Al-Ghamdi; E.I. Azhar
10/21/2017
FVL; MTHFR; PTH; RSM; Saudi Arabia
Maternally inherited thrombophilia could be one of the causes of recurrent spontaneous miscarriage (RSM). We aimed to investigate the frequency of three thrombotic gene variants; factor V Leiden (FVL; G1691A), prothrombin (PTH; G20210A), and methylenetetrahydrofolate reductase (MTHFR; C677T) in Saudi patients diagnosed with RSM. A case control study was conducted ... more
F. Eldeen; A. Badawy; A. AlSel; M.S. Fawzy
04/30/2019
Breast cancer; Genetic polymorphism; HLA-G; Saudi Arabia

Human leukocyte antigen-G (HLA-G) has been associated with various immune diseases, including malignancies. The 14-base pair (bp) insertion/deletion (indel) polymorphism (rs16375) in exon 8 of the 3′ untranslated region (3′ UTR) of the HLA-G gene has been reported to influence HLA-G protein expression. We investigated the relationship between the 14-bp indel ... more

S.Y.Al Omar; L. Mansour
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Colorectal cancer; Genetic association; HLA-G; Immune tolerance; Saudi Arabia

Human leukocyte antigen (HLA) G, a non-classical HLA class I (MHC class I) molecule, is characterized by a low degree of polymorphism, unlike classical MHC-I. The 14-base pair insertion/deletion (indel) polymorphism (rs16375) in exon 8 of the 3′ untranslated region has been reported to control HLA-G expression transcriptionally and ... more

A. Hassan; A. Omar; H. Halawani; M. Arafah; S. Alqadheeb; J. Al-Tamimi; L. Mansour
06/30/2019
Gene polymorphisms; HFE; Lead exposure; PON1; Saudi Arabia

Serum paraoxonase (PON1) and hemochromatosis (HFE) genes may play important roles in lead toxicity owing to their role in xenobiotic and iron metabolism, respectively. The association between PON1 and HFE genotypes and blood lead levels (BLLs) was examined in lead exposed subjects from Saudi Arabia. The polymorphisms at PON1 L55M, PON1 Q192R, HFE H63D and HFE C282Y ... more

A.P. Shaik; A.H. Alsaeed; M. Faiyaz-ul-Haque; M.A. Alsaeed; A.S. Shaik
12/02/2015
IL-10; Lung injury; Lung protection; rhKGF-2; Ventilation

A rat model of ventilation-induced lung injury (VILI) during anesthesia was generated to investigate the potential role and possible mechanism of interleukin-10 (IL-10) and recombinant human keratinocyte growth factor-2 (rhKGF-2) in protecting anesthetized rats against VILI. A total of 50 male SD rats were randomly divided into 5 groups (N = 10 each): control, VILI, IL-10, rhKGF-2, and ... more

J.Y. Wu; Z.H. Xiong; G.Z. Xiong; F.Q. Ding; J. Lei; S. Lu; Y. Li; G.M. He; L.L. Zhao; Z.J. Liu
03/24/2016
Allele specific PCR; Breast cancer; IL-10; IL-6; Interleukin; Promoter polymorphisms

Polymorphisms in interleukin genes (IL-6 and IL-10) are involved in the pathogenesis of breast cancer. This study investigated polymorphisms in the promoter regions of IL-6 (-174G/C) and IL-10 (-1082G/A) through a case-control study employing 80 female subjects who were pathologically diagnosed with breast cancer. All patients received follow-up care at ... more

E.S. AlSuhaibani; N.A. Kizilbash; S. Malik; J.I. Dasti; A. Beladi; N. El-Morshedi; E.S. AlSuhaibani; N.A. Kizilbash; S. Malik; J.I. Dasti; A. Beladi; N. El-Morshedi; E.S. AlSuhaibani; N.A. Kizilbash; S. Malik; J.I. Dasti; A. Beladi; N. El-Morshedi
03/18/2016
Hepatitis B virus; Hepatocellular carcinoma; IL-10; Polymorphism

We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms of IL-10 (-592G/A, -819T/C, and -1082A/C) in the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The study included 173 HBV-related HCC patients and 182 healthy controls. A polymerase chain reaction-restriction fragment length polymorphism ... more

M.W. Peng; S.Q. Lu; J. Liu; C.Y. Dong; M.W. Peng; S.Q. Lu; J. Liu; C.Y. Dong; M.W. Peng; S.Q. Lu; J. Liu; C.Y. Dong

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