Research Article

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Fertility; Genetic association; Hatchability; Heritability; White leghorn

Studies estimating genetic parameters for reproductive traits in chickens can be useful for understanding and improvement of their genetic architecture. A total of 1276 observations of fertility (FERT), hatchability of fertile eggs (HFE) and hatchability of total eggs (HTE) were used to estimate the genetic and phenotypic parameters of 467 females from an F2 population generated by ... more

R.P. Savegnago; M.E. Buzanskas; B.N. Nunes; S.B. Ramos; M.C. Ledur; K. Nones; D.P. Munari
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Bone mineral density; Bone morphogenetic protein 2 and 4; Genetic association; Osteoporosis; Single-nucleotide polymorphism

We investigated the effect of bone morphogenetic protein 2 and 4 (BMP-2 and -4) gene polymorphisms on bone density in postmenopausal Turkish women with osteoporosis. The frequency of single-nucleotide polymorphisms (SNPs) of BMP-2 and -4 genes was analyzed in 101 osteoporotic-postmenopausal women and 52 postmenopausal women with positive bone mineral density scores. We evaluated the ... more

Z.S. Özkan; D. Deveci; E. Önalan; H. Yüce
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CCND1 gene; Esophageal cancer; Genetic association; Meta-analysis; Polymorphism

The association between the Cyclin D1 gene (CCND1) G870A polymorphism and esophageal cancer has been widely evaluated, with conflicting results. As meta-analysis is a reliable approach to resolving discrepancies, we aimed to evaluate this association. Data were available from 9 study populations incorporating 1898 cases and 3046 controls. Overall, the allelic/genotypic ... more

W. Cai; Z.T. Wang; J. Zhong; Y. Zhang
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Genetic association; Genetic polymorphism; Holstein cows; Molecular markers

The bovine prolactin (PRL) and bovine growth hormone (bGH) genes exhibit several polymorphisms. Some of them can be detected by molecular techniques using restriction endonucleases, such as RsaI for the PRL gene and MspI for the bGH gene. We examined the relationship between the PRL-RsaI and bGH-MspI polymorphisms and ... more

J.C. Rincón; A. López-Herrera; J.J. Echeverri
03/31/2014
BMP-2; COL6A1; Genetic association; Ossification of the posterior longitudinal ligament; Single nucleotide polymorphism

COL6A1 and BMP-2 genes have been implicated in ossification of the posterior longitudinal ligament (OPLL) susceptibility in Japanese and Chinese Han populations. However, no study has yet investigated the DNA of unaffected family members of patients with OPLL. This study investigated differences in genetic polymorphisms of BMP-2 and COL6A1 between Korean patients with ... more

K.H. Kim; S.U. Kuh; J.Y. Park; S.J. Lee; H.S. Park; D.K. Chin; K.S. Kim; Y.E. Cho
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E23K variant; Genetic association; HDL-C; KCNJ11 gene; Nigeria; Type 2 diabetes

Though the rs5219 E23K variant of the KCNJ11 gene is commonly known to be associated with Type 2 diabetes (T2D) in Caucasian and Asian populations, little or none of such findings have been revealed in Nigeria. Hence, this study was aimed to assess the relationship between E23K polymorphic variant of the KCNJ11 gene and T2D in a Nigerian population. A case-control ... more

G.Azeh Engwa; F.Nweke Nwalo; C.E. Obi; C. Onyia; O.Oyejide Oj Mbacham; B.Ewa Ubi
06/17/2019
Colorectal cancer; Genetic association; HLA-G; Immune tolerance; Saudi Arabia

Human leukocyte antigen (HLA) G, a non-classical HLA class I (MHC class I) molecule, is characterized by a low degree of polymorphism, unlike classical MHC-I. The 14-base pair insertion/deletion (indel) polymorphism (rs16375) in exon 8 of the 3′ untranslated region has been reported to control HLA-G expression transcriptionally and ... more

A. Hassan; A. Omar; H. Halawani; M. Arafah; S. Alqadheeb; J. Al-Tamimi; L. Mansour
07/17/2019
Genetic association; Genotyping; Maternal line; SNPs; Sus scrofa domesticus

MC4R, FABP3 and DGAT1 are important genes related to productive and reproductive traits in pigs, such as food intake, growth rate, back fat thickness reduction and lactation. Selection of pigs for lean meat production may lead to losses in reproductive charcters because reduction of backfat thickness and low feed intake during the lactation phase ... more

V.S. Gondim; J.S. Soares; N.A.H. Lugo; N.B. Stafuzza; G.S. Vieira; R.R. Aspilcueta-Borquis; L.A.F. Pascoal; A.C.P. Silveira; H. Tonhati; R.C. Antunes
02/28/2021
Genetic association; Genetic risk factors; Obesity; TCF7L2 G/T polymorphism; Type 2 diabetes

Polymorphisms of the transcription factor 7–like 2 (TCF7L2) gene have been associated with susceptibility to type 2 diabetes (T2D) in various ethnic populations, but have not been previously studied in a Nigerian population. We investigated the relationship between the TCF7L2 rs12255372 (G/T) polymorphism and type 2 diabetes (T2D) in a Nigerian ... more

G.A. Engwa; F.N. Nwalo; C.O. Ozokonkwo; K.N. Agbafor; B.N. Nkeh-Chungag; B.E. Ubi
01/22/2013
ACE I/D polymorphism; Meta-analysis; OSAHS; Severity

Published data on a possible association between the angiotensin-converting enzyme (ACE) gene I/D polymorphism and obstructive sleep apnea-hypopnea syndrome (OSAHS) occurrence and its severity risk are inconclusive. We performed a meta-analysis of case-control studies published in English or Chinese. Thirteen studies, totaling 1361 cases and 1373 controls, were investigated for ... more

Y. Feng; J. Ri; H.Y. Wan; G.C. Shi; Q.Y. Li; L. Fan

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