Research Article

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12/29/2015
GSTM1; GSTT1; Meta-analysis; Polymorphism; Varicocele

The glutathione S-transferase (GST) family represents a major group of detoxification and antioxidant enzymes. Studies have shown that high oxidative stress levels are associated with varicocele. The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patients and 476 ... more

B. Zhu; L. Yin; J.Y. Zhang
07/31/2019
GSTM1; GSTT1; Polymorphism; Prostate cancer; Risk factor

Prostate cancer (PCa) is the second most common type of tumor among men over 50 years old and its etiology includes environmental, demographic, and genetic risk factors. We investigated a possible association between GSTM1 and GSTT1 polymorphisms, sociodemographic, and clinical factors with PCa in a population of southwestern Bahia, Brazil. The ... more

L.C.F. de Souza; T.L.S. Brito; A.T. Almeida; Y.P. Muniz; P.B. Nishiyama; C.L. Souza; L. Tomazi
02/25/2019
Cervical cancer; GSTM1; GSTT1; Smoking

Human papillomavirus infection is the main risk factor for cervical cancer. Other risk factors include smoking and genetic susceptibility. Glutathione-S-transferases are enzymes involved in tobacco carcinogen metabolism, and genes encoding these enzymes are highly polymorphic. We compared the frequencies of GSTM1 and GSTT1 null polymorphisms in ... more

A.L.M. Tacca; A.K. Lopes; C.A.S.T. Vilanova-Costa; A.M.T.C. Silva; S.H.N. Costa; N.A. Nogueira; J.E.P. Ramos; A.A. Ribeiro; V.A. Saddi
02/25/2019
Atherosclerosis; eNOS; GSTM1; GSTT1; Hypertension

Atherosclerosis is a multifactorial chronic inflammatory disease that occurs in response to endothelial aggression. Systemic arterial hypertension is the main risk factor for the formation of atheromas, increasing the risk of cardiovascular diseases. Several genes are involved in atherogenesis and hypertension. We analyzed polymorphisms of candidate genes that ... more

M.P. Moraes; K.S.Fe Silva; M.H. Lagares; A.M. Barbosa; J.V.M. Martins; F.L. Campedelli; I.R. da Costa; D.A. Rodrigues; K.K.V.O. Moura
09/30/2003
Chromosome aberrations; Hydroxyurea; Mitotic index; Sickle cell anemia

Hydroxyurea is considered an antineoplastic drug, which also plays an important role in the treatment of sickle cell anemia patients. We evaluated and compared the clastogenic and cytotoxic effects of hydroxyurea, using chromosomal aberrations and mitotic index, respectively, as endpoints. In vitro short-term cultures of lymphocytes were exposed to several concentrations of this drug, ... more

P.Danielle L. de Lima; P.Cerqueira Cardoso; A.Salim Khayat; Mde Oliveir Bahia; R.Rodríguez Burbano
05/10/2011
Oxidative stress; Polymorphism; Sickle cell anemia; Superoxide dismutase

Oxidative stress may be contributory to the pathophy­siology of the abnormalities that underlie the clinical course of sickle cell anemia. We looked for a possible genetic association between the functional polymorphism Ala-9Val in the human Mn-SOD gene and sickle cell anemia. One hundred and twenty-seven patients with sickle cell anemia and 127 healthy controls were recruited into the ... more

S. Sogut; Z. Yonden; H. Kaya; S. Oktar; M. Tutanc; H.R. Yilmaz; A. Yigit; N. Ozcelik; E. Gali
03/02/2010
Aquatic rehabilitation; Hemoglobinopathy; Kinesiotherapy; Sickle cell anemia

The process of hemoglobin polymerization and the consequent sickling of red blood cells that occurs in patients with sickle cell disease shortens the half-life of red blood cells. It causes vaso-occlusive complications, as well as pain and pulmonary and cardiovascular dysfunction. We evaluated an aquatic rehabilitation program used for patients with sickle cell anemia and examined the possible ... more

G. Tinti; R. Somera; F.M. Valente; C.R.B. Domingos
03/31/2019
HbAS; Hypochromic anemia; Microcytic anemia; Sickle cell anemia; βS Haplotypes

Heterozygosis for the hemoglobin S allele is a relatively common condition that is clinically benign and rarely presents clinical or hematological manifestations. Although rare, symptoms have been reported in these patients. We examined clinical manifestations and laboratory findings in HbAS individuals that could be related to the βS haplotypes: in 31 ... more

L.X. Souza; J.S. Oliveira; L.O. Guimarães; C.M.B.T. Leite; R. Pereira; A.A.L. Barbosa; J.C.Silva Junior
04/28/2016
Chemotherapy; GSTM1; GSTP1 polymorphism; GSTT1; NSCLC

The aim of this study was to evaluate the association of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms with the chemotherapy response and overall survival of advanced NSCLC. Two hundred and sixty-two patients with histologically confirmed advanced NSCLC (inoperable TNM stages IIIA, IIIB, and IV) were enrolled to this hospital-based ... more

H.L. Xiao; Z.T. Yang; F. Han; H.X. Wei; H.L. Xiao; Z.T. Yang; F. Han; H.X. Wei; H.L. Xiao; Z.T. Yang; F. Han; H.X. Wei

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