Research Article

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06/17/2019
Colorectal cancer; Genetic association; HLA-G; Immune tolerance; Saudi Arabia

Human leukocyte antigen (HLA) G, a non-classical HLA class I (MHC class I) molecule, is characterized by a low degree of polymorphism, unlike classical MHC-I. The 14-base pair insertion/deletion (indel) polymorphism (rs16375) in exon 8 of the 3′ untranslated region has been reported to control HLA-G expression transcriptionally and ... more

A. Hassan; A. Omar; H. Halawani; M. Arafah; S. Alqadheeb; J. Al-Tamimi; L. Mansour
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-2578C/A; Breast cancer; Genetic polymorphism; Meta-analysis; VEGF; 405G/C

This study aimed to analyze the association between the 405G/C and -2578C/A polymorphisms of the vascular endothelial growth factor (VEGF) gene and breast cancer risk by meta-analysis. A systematic computerized search of PubMed, Google Scholar, and Web of Science databases was performed to identify relevant publications. After rigorous searching and screening, 9 eligible case- ... more

Y. Zhang; Y.F. Yu; J.Z. Wang; H. Jia
10/02/2015
Asteraceae; Echinops abuzinadianus; Endemic species; Internal transcribed spacer; Saudi Arabia

The present study explored the systematic inventory of Echinops L. (Asteraceae) of Saudi Arabia, with special reference to the molecular typing of Echinops abuzinadianus Chaudhary, an endemic species to Saudi Arabia, based on the internal transcribed spacer (ITS) sequences (ITS1-5.8S-ITS2) of nuclear ribosomal DNA. A sequence similarity search using BLAST and a ... more

M.A. Ali; F.M. Al-Hemaid; J. Lee; A.A. Hatamleh; G. Gyulai; M.O. Rahman
02/16/2017
Adult; Aged; Aged, 80 and over; Arabs; Colorectal neoplasms; Exons; Female; Humans; male; Middle Aged; Mutation; Mutation Rate; Prognosis; Proto-Oncogene Proteins p21(ras); Retrospective Studies; Saudi Arabia; Survival analysis; Young Adult

Mutations in codons 12/13 of K-ras exon 2 are associated with reduced benefit from anti-epidermal growth factor receptor antibody treatment for metastatic colorectal cancer (CRC). Here, we evaluated the frequency of K-ras mutations and their relationship with clinicopathological features and treatment outcomes in Saudi Arabian patients with CRC. The genetic status of K-ras was determined in ... more

J. Zekri; A. Al-Shehri; M. Mahrous; S. Al-Rehaily; T. Darwish; S. Bassi; E. Taani; A. Zahrani; S. Elsamany; J. Al-Maghrabi; B.B. Sadiq
06/20/2017
Antifungal Agents; Bacteria; Bacterial Proteins; Biodiversity; Biotechnology; DNA, Ribosomal; Endophytes; Genetic variation; Hydrolases; Rhizosphere; Saudi Arabia; Seawater; Wetlands

Marine bacteria have been exceptional sources of halotolerant enzymes since decades. The aim of the present study was to isolate bacteria producing hydrolytic enzymes from seven different mangroves collected from the coastal area of Thuwal, Jeddah, Saudi Arabia, and to further screen them for other enzymatic and antifungal activities. We have isolated 46 different rhizo- and endophytic ... more

F. Bibi; I. Ullah; S.A. Alvi; S.A. Bakhsh; M. Yasir; A.A.K. Al-Ghamdi; E.I. Azhar
10/21/2017
FVL; MTHFR; PTH; RSM; Saudi Arabia
Maternally inherited thrombophilia could be one of the causes of recurrent spontaneous miscarriage (RSM). We aimed to investigate the frequency of three thrombotic gene variants; factor V Leiden (FVL; G1691A), prothrombin (PTH; G20210A), and methylenetetrahydrofolate reductase (MTHFR; C677T) in Saudi patients diagnosed with RSM. A case control study was conducted ... more
F. Eldeen; A. Badawy; A. AlSel; M.S. Fawzy
06/30/2019
Gene polymorphisms; HFE; Lead exposure; PON1; Saudi Arabia

Serum paraoxonase (PON1) and hemochromatosis (HFE) genes may play important roles in lead toxicity owing to their role in xenobiotic and iron metabolism, respectively. The association between PON1 and HFE genotypes and blood lead levels (BLLs) was examined in lead exposed subjects from Saudi Arabia. The polymorphisms at PON1 L55M, PON1 Q192R, HFE H63D and HFE C282Y ... more

A.P. Shaik; A.H. Alsaeed; M. Faiyaz-ul-Haque; M.A. Alsaeed; A.S. Shaik
07/04/2019
IL-10; Polycystic ovary syndrome (PCOS); Saudi Arabia; TNF-α gene polymorphism

Polycystic ovarian syndrome (PCOS) is the most prevalent endocrine disorder affecting females. It is a common cause of menstrual irregularities and infertility during a woman’s reproductive years. Many factors may play a crucial role in the pathogenesis of POCS. One of these factors is related to immunogenetics. Cytokines are significant immunomodulatory proteins ... more

A.F. Alkhuriji; S.Y.Al Omar; Z.A. Babay; M.F. El-khadragy; W.G. Allharbi; A.A. Alnafjan
08/26/2016
Association studies; Genetic polymorphism; HLA-G; Liver neoplasms; MHC class I

Human leukocyte antigen (HLA)-G is a key tolerogenic molecule mainly expressed in the placenta and is crucial for implantation of the embryo and immunological tolerance of the fetus during pregnancy. However, under pathological conditions, such as cancer or viral infections, HLA-G can be expressed in other tissues. The gene coding for HLA-G (HLA-G, chromosome 6p21.3) presents ... more

A.V.C. Coelho; R.R. Moura; S. Crovella; F. Celsi; A.V.C. Coelho; R.R. Moura; S. Crovella; F. Celsi
09/21/2015
Breast cancer; GIT2; Metastasis; MTERF; Multiplex RT-PCR

Quantitative multiplex reverse transcriptase-polymerase chain reaction was developed for the simultaneous detection of multiple-gene expression levels of formalin-fixed, paraffin-embedded breast cancer samples. Candidate genes were selected from previous microarray data relevant to breast cancer markers that had the potential to serve as predictive markers for metastatic risk. This multiplex ... more

S. Sirirattanakul; P. Wannakrairot; T. Tencomnao; R. Santiyanont

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