Research Article

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12/06/2011
GSTP1; Kashmir; Polymorphism; Prostate cancer; Restriction digestion; RFLP

Glutathione-S-transferase P1 (GSTP1) is a critical enzyme of the phase II detoxification pathway. One of the common functional polymorphisms of GSTP1 is A→G at nucleotide 313, which results in an amino acid substitution (Ile105Val) at the substrate binding site of GSTP1 and reduces catalytic activity of GSTP1. To investigate the GSTP1 Ile105Val genotype ... more

Q. Qadri; A.S. Sameer; Z.A. Shah; A. Hamid; S. Alam; S. Manzoor; M.A. Siddiqi
06/15/2012
Genetic polymorphisms; Meta-analysis; Prostate cancer; PTGS2

Evidence is accumulating that chronic inflammation has an important role in prostate cancer. Two common polymorphisms in the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, rs20417 and rs689470, have been found to alter the risk for prostate cancer, but the various studies are not in agreement. To derive a more precise estimation of this association, all available studies were ... more

H.T. Zhang; Y. Xu; Z.H. Zhang; L. Li
08/25/2011
Association analysis; Body measurement; Cattle; CDK6 gene; SNP polymorphism

Cyclin-dependent kinase 6 (CDK6) is a key element of D-type cyclin holoenzymes. It is involved in the regulation of the G1-phase of the cell cycle and is considered to be an important candidate gene for selection of body measurement traits through marker-assisted selection. We cloned the promoter sequence of this gene in bovines and found it to share high similarity with that of the human ... more

Y.F. Liu; L.S. Zan; W.T. Cui; Y.P. Xin; Y. Jiao; K. Li
09/19/2013
Association analysis; Genetic polymorphisms; susceptibility; Toll-like receptor 4; Type 2 diabetes mellitus

Toll-like receptor 4 (TLR4) is potentially an important gene affecting the susceptibility to type 2 diabetes mellitus (T2DM). The objective of this study was to evaluate whether genetic polymorphisms of the TLR4 gene are associated with T2DM susceptibility. This potential association was analyzed in 668 T2DM patients and 672 healthy controls by polymerase chain reaction- ... more

X.D. Fu; X.Q. Sun; H.Y. Wang; J.F. Guo; G.Z. Zhang; Q.H. Xu
09/13/2013
APOA5 gene; APOC3 gene; Association analysis; Kele pig; meat quality

Apolipoprotein A5 (APOA5) and C3 (APOC3) genes are involved in the PPAR lipid metabolism pathway and thus associated with elevated triglyceride levels. However, whether APOA5 and APOC3 genetic polymorphisms affect intramuscular fat deposition and other meat quality traits remains unknown in pigs. One hundred and seventy-one Kele pigs were sampled to ... more

Y.T. Hui; Y.Q. Yang; R.Y. Liu; Y.Y. Zhang; C.J. Xiang; Z.Z. Liu; Y.H. Ding; Y.L. Zhang; B.R. Wang
09/13/2013
Association analysis; Growth performance; Promoter; STAM2 gene; Wuchuan Black cattle

The STAM protein plays an important role in the cytokine-related JAK/STAT pathway. We selected the STAM2 gene as a candidate gene that could be linked to growth performance in analysis of a Chinese cattle breed (Wuchuan Black cattle). We examined genetic variants in the promoter region of the STAM2 gene and their associations with eight growth traits in 159 individuals. ... more

Y.Q. Yang; Y.T. Hui; R.Y. Liu; R.G. Jiao; Y. Gong; Y.Y. Zhang; H.Q. Xie
09/04/2013
Association analysis; Gossypium barbadense; SRAP; SSR

Cotton is an important cash crop. Mining for quantitative trait loci related to yield and fiber quality traits using association analysis has many advantages for cotton research. In this study, 170 simple sequence repeats (SSRs) and 258 sequence-related amplified polymorphisms (SRAPs) were used to analyze the association of 3 yield component traits and 5 fiber quality traits of 55 ... more

X.Q. Wang; Y. Yu; W. Li; H.L. Guo; Z.X. Lin; X.L. Zhang
09/04/2013
Alpha-lactalbumin gene; Association analysis; Chinese Holstein cows; Milk production traits; SNP

The traits particularly important for milk production include milk yield, protein percentage, fat percentage, and the somatic cell score. Alpha-lactalbumin (α-LA) is an important whey protein of cow milk, and is also present in the milk of many other mammalian species. In this study, we analyzed the genetic polymorphisms of the α-LA gene and their relationship to milk production traits ( ... more

J.P. Zhou; C.H. Dong
09/03/2013
Association analysis; Bone mineral density; Osteoporosis; Osteoprotegerin gene; Postmenopausal women; Single nucleotide polymorphisms

Osteoporosis is an important and common complex health problem, particularly in postmenopausal women. It is characterized by a reduction in bone mineral density (BMD) and a deterioration of bone microarchitecture with a consequent increase of fracture risk. The osteoprotegerin (OPG) gene is considered to play an important role in the pathogenesis of osteoporosis. We analyzed SNPs ... more

J.F. Song; Z.Z. Jing; W. Hu; Y.X. Su
05/08/2012
Association analysis; Insig-1; Qinchuan cattle; SNPs

The insulin-induced gene 1 (Insig-1) is a regulator of lipid metabolism and plays an important role in the sterol-mediated regulation of SREBP, SCAP and HMG-CoA reductase. We used PCR-RFLP and DNA sequencing to detect polymorphisms of the Insig-1 gene in 215 individuals of the Qinchuan cattle breed. Four SNPs [4366(A>G), 4534(T>C), 5001(T>C), and 5235(G>A)] were indentified. ... more

Y. Liu; X.L. Liu; H. He; Y.L. Gu

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