Research Article

Related GMR Articles

Atherosclerosis; Diabetes; Dyslipidemia; eNOS; Hypertension

Atherosclerosis is a chronic multifactorial inflammatory disease that evolves in response to aggression of the endothelium, causing plaque formation in large or medium-sized arteries. Various co-factors can accelerate the evolution of this pathology, such as systemic arterial hypertension, dyslipidemia and diabetes mellitus. Given that nitrous oxide is a potent ... more

F.R.B. Oliveira; J.F. Corrêa; K.S.F. Silva; I.A. Costa; R.S. Mascarenhas; A.M. Barbosa; M.H. Lagares; F.L. Campedelli; K.K.V.O. Moura
GSTM1; GSTT1; Meta-analysis; Polymorphism; Varicocele

The glutathione S-transferase (GST) family represents a major group of detoxification and antioxidant enzymes. Studies have shown that high oxidative stress levels are associated with varicocele. The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patients and 476 ... more

B. Zhu; L. Yin; J.Y. Zhang
Cervical cancer; GSTM1; GSTT1; Smoking

Human papillomavirus infection is the main risk factor for cervical cancer. Other risk factors include smoking and genetic susceptibility. Glutathione-S-transferases are enzymes involved in tobacco carcinogen metabolism, and genes encoding these enzymes are highly polymorphic. We compared the frequencies of GSTM1 and GSTT1 null polymorphisms in ... more

A.L.M. Tacca; A.K. Lopes; C.A.S.T. Vilanova-Costa; A.M.T.C. Silva; S.H.N. Costa; N.A. Nogueira; J.E.P. Ramos; A.A. Ribeiro; V.A. Saddi
GSTM1; GSTT1; Polymorphism; Prognosis; Sickle cell anemia

Sickle cell anemia is one of the most common genetic diseases in Brazil. This disease has an autosomal recessive inheritance pattern with a point mutation on chromosome 11, which is the substitution of an adenine by thymine. This mutation leads to the exchange of a glutamic acid for a valine at residue 6 of the beta globin chain, resulting in an abnormal form of hemoglobin, the so-called ... more

O.S.Dias Neto; K.S.Fe Silva; A.M. Barbosa; D.A. Rodrigues; M.H. Lagares; I.R. da Costa; K.K.V.O. Moura
GSTM1; GSTT1; Polymorphism; Prostate cancer; Risk factor

Prostate cancer (PCa) is the second most common type of tumor among men over 50 years old and its etiology includes environmental, demographic, and genetic risk factors. We investigated a possible association between GSTM1 and GSTT1 polymorphisms, sociodemographic, and clinical factors with PCa in a population of southwestern Bahia, Brazil. The ... more

L.C.F. de Souza; T.L.S. Brito; A.T. Almeida; Y.P. Muniz; P.B. Nishiyama; C.L. Souza; L. Tomazi
Glutathione-S-transferase; GSTM1; GSTT1; Oral cancer risk; Polymorphisms

The development of oral cancer results from interactions between genetic and environmental factors. Glutathione-S-transferase gene null polymorphisms have a strong impact on the detoxification of carcinogens; therefore they are expected to be related to oncogenic risk, including oral cancer. Various studies have evaluated a possible association of ... more

A.K. Lopes; A.L.M. Tacca; N.A. Nogueira; J.A. Sodario; C.A.S.T. Vilanova-Costa; V.A. Saddi; A.Vde Moraes Filho; A.M.T.C. Silva
Chinese Han population; eNOS; Genetic polymorphisms; MnSOD; Type 2 diabetes mellitus

Impaired antioxidant defense increases the oxidative stress and contributes to the development of type 2 diabetes mellitus (T2DM). MnSOD and eNOS are important antioxidant enzymes. This aim of this study was to verify the association of MnSOD and eNOS tagSNPs with T2DM in a Chinese Han population. Four tagSNPs of MnSOD and eight tagSNPs of eNOS were ... more

J.Y. Li; F. Tao; X.X. Wu; Y.Z. Tan; L. He; H. Lu
Arg72Pro; Endometriosis; eNOS; Glu298Asp; p53; Polymorphism

Endometriosis is characterized by ectopic endometrial tissue and affects millions of women worldwide. The disease leads to various symptoms such as chronic pelvic pain and infertility and does not yet have a well-defined etiology. The pathology is similar to cancer, since endometrial cells are highly proliferative, invade tissues and may be associated with tumor suppressor ... more

T.R. Santos; K.S.Fe Silva; R.C.P.C. Silva; K.K.V.O. Moura; L.A. Guillo; C.L.Ribeiro Júnior; I.R. Costa
Endometriosis; eNOS; Genotype; Infertility; Polymorphism

Endometriosis is a chronic disease with adverse implications for fertility. We investigated the G894T polymorphism in the endothelial nitric oxide synthase gene in fertile and infertile women with endometriosis. This prospective study included a group of 52 women with a laparoscopic diagnosis of endometriosis. DNA was extracted from blood obtained from 47 patients ... more

R.C.P.Ce Silva; L.C. de Faria; K.S.Fe Silva; K.K.V.O. Moura; C.L.Ribeiro Júnior; L.A. Guillo
4-dien-1-one (GBOT); 4-Dihydroxy-phenyl)-1-piperidin-1-yl-penta-2; 5-(3; Atherosclerosis; Blood glucose; Blood lipid metabolism

We observed the variation in in vivo blood lipid and blood glucose metabolism in rats with atherosclerosis after 5-(3,4-dihydroxy-phenyl)-1-piperidin-1-yl-penta-2,4-dien-1-one (GBOT) administration. Wistar rats aged 10 weeks received a high-fat diet to establish the atherosclerosis model. Metabolic indices related to blood lipid and blood glucose were measured before modeling ... more

A. Rong; G. Borjihan; Y.J. Qiao