Research Article

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03/09/2006
Biological monitoring; Exfoliated cells; Gas station attendants; Micronucleus test; Mutagenicity; Occupational exposure

In the present study, the micronucleus test was applied in exfoliated cells of buccal mucosa to assess the mutagenicity risk associated with occupational exposure for gas station attendants. For each individual, 2000 exfoliated buccal cells were analyzed for micronucleus frequency. A highly significant difference was found between exposed and control groups. Likewise, a significant ... more

C.Iribarrem Benites; L.Lund Amado; R.Aloma Pack Vianna; Mda Graça Martino-Roth
09/01/2009
Allium cepa; Hydrocotyle ranunculoides; Mutagenicity; Pelotas Creek

Water resource degradation is one of mankind’s greatest worries, as it causes direct and indirect damage to the associated biota. We initiated a water monitoring study in Pelotas Creek in 2003 in order to assess the mutagenic effect of the creek’s waters. Allium cepa cells exposed to water samples and a chronically exposed macrophyte were analyzed, through evaluation of the ... more

T.C.O. Santos; L.F. Maciel; K.S. Leal; A.E.N. Bender; T.S. Paiva; G.L. Garcias; M.G. Martino-Roth
03/17/2009
Allium cepa; Anomalies; Channel; Meristems; Mutagenicity

The São Gonçalo Channel is of great importance to the conservation of local biodiversity; it also is a water supply source of the city of Pelotas, Brazil, and the surrounding region. We examined the mutagenic activity of its waters. The following items were seasonally investigated in Allium cepa root radicular meristem cells: mitotic index, mitotic anomalies, interphase anomalies, and ... more

T.S. Paiva; G.L. Garcias; M.G. Martino-Roth
05/20/2008
chronic renal disease; hemodialysis patients; Micronucleus; Mutagenicity; peritoneal dialysis patients

Patients with chronic renal disease have an increased incidence of cancer. It is well known that long periods of hemodialysis treatment are linked to DNA damage due to oxidative stress. This genotoxic effect may cause the loss of chromosome fragments, or even entire chromosomes, which form micronuclei after cell division, and can be detected by the micronucleus test. In the present case- ... more

J.M. Roth; R.G. Restani; T.T.S. Gonçalves; S.L.S. Sphor; A.B. Ness; M.G. Martino-Roth; G.L. Garcias
01/18/2011
Antimutagenicity; Duguetia furfuracea; Genotoxicity; Mutagenicity

Mutagenic and antimutagenic activities of the medicinal plant Duguetia furfuracea were assessed using SMART/wing and ring-X-loss tests. For the ring-X-loss test, 2- to 3-day-old Drosophila melanogaster ring-X-lineage males and virgin ywsn3 females received D. furfuracea infusion at doses of 0.085, 0.042, or 0.014 g/mL for 24 h. We found that D. furfuracea ... more

L.S. Coelho; L.P. Felício; C.T. Miranda; C.R. Vale; D.C.S. Lima; S.R. Duarte; H.D. Ferreira; C. Chen; S. Carvalho; E.M. da Silva
09/13/2013
Chromonephthea braziliensis; Mutagenicity; Secondary metabolites; Toxicity

Coral reefs are diverse ecosystems that have a high density of biodiversity leading to intense competition among species. These species may produce unknown substances, many with pharmacological value. Chromonephthea braziliensis is an invasive soft coral from the Indo-Pacific Ocean that is possibly transported by oil platforms and whose presence can be a threat to a region’s ... more

R.M. Carpes; B.G. Fleury; B.G. Lages; A.C. Pinto; C.A.F. Aiub; I. Felzenszwalb
02/27/2013
Antimutagenicity; In vivo; Mutagenicity; Phytoestrogen

Studies show that soy imparts many favorable properties in the human body, including the prevention of chronic diseases such as osteoporosis, heart disease, cancer, and diabetes. Soy is rich in isoflavones, and it is a candidate for the chemoprevention of diseases owing to its low toxicity. In this study, a soy phytoestrogen (with high levels of the isoflavones genistin and daidzein) was ... more

A.M. Niwa; R.J. Oliveira; M.S. Mantovani
09/03/2012
Antimutagenicity; Antioxidant; Grape juice; Minerals; Mutagenicity

Grape juices are an important source of food antioxidants. Unfortunately, there is little data about the mineral composition and the antioxidant, mutagenic and antimutagenic activities of grape juice in eukaryote cells. We evaluated the mineral contents (Mg, Ca, Mn, Fe, Cu, Zn, Si, S, Cl) of grape juices, the antioxidant, mutagenic and/or antimutagenic activities of the juices in the ... more

C. Dani; L.S. Oliboni; D. Prá; D. Bonatto; C.E.I. Santos; M.L. Yoneama; J.F. Dias; M. Salvador; J.A.P. Henriques
05/09/2014
Mutagenicity; Nitroarenes; Salmonella enterica serovar Typhimurium; Sensitivity

The use of strains of Salmonella enterica serovar Typhimurium with different metabolic capacities can indicate the class or classes of compounds present in an environmental sample and enable the diagnosis of the mutagenic activity of these pollutants adsorbed on particulate matter (PM) in the air. In the present study, the sensitivity of Salmonella strains TA98NR, TA98/1 ... more

C.R. Rainho; S.M. Corrêa; J.L. Mazzei; C.A.F. Aiub; I. Felzenszwalb
03/31/2014
Carotenoid; Mutagenicity; Natural compound; Radioisotope

Radioactive iodine-131 (131I) is used in the treatment and diagnosis of thyroid gland injuries. However, because it emits ionizing radiation, it causes harmful effects to cells. Given that beta-carotene (BC) has antioxidant and antigenotoxic properties, this study aimed to investigate its radioprotective and antimutagenic activity in relation to 131I at the dose that is used to treat ... more

A.P. Berti; E. Düsman; R.G. Mariucci; N.B. Lopes; V.E.P. Vicentini

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