Research Article

Related GMR Articles

06/11/2015
Endothelial cells; Hydrogen; Lipopolysaccharide; Sepsis; Vascular endothelial-cadherin

We observed the effect of hydrogen-rich medium on lipopolysaccharide (LPS)-induced human umbilical vein endothelial cells (HUVECs), hyaline leukocyte conglutination, and permeability of the endothelium. Endotheliocytes were inoculated on 6-well plates and randomly divided into 4 groups: control, H2, LPS, LPS+H2, H2, and LPS+H2 in saturated ... more

Y. Yu; W.N. Wang; H.Z. Han; K.L. Xie; G.L. Wang; Y.H. Yu
04/28/2015
Cyclophilin-D protein; Endothelial cells; Oxidative stress

We examined the influence of cyclophilin-D (CypD) protein expression level on endothelial cell oxidative damage resistance. A model of CypD protein expression or high expression in endothelial cells was established through gene silencing or cloning. The comparable groups were normal endothelial cells cultured in phosphate-buffered solution in liquid handling cells containing 500 mM H ... more

J.Z. Peng; L. Xue; J. Chen; B.S. Chen; Y.Q. Yang
11/18/2013
-308G>A; Breast cancer; Mexican population; Obesity; Risk factor; Tumor necrosis factor alpha

The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes of 294 healthy Mexican women with ... more

G. Flores-Ramos; E. De Dios; A.M. Puebla-Pérez; L.E. Figuera-Villanueva; A. Ramos-Silva; R. Ramírez-Patiño; J.I. Delgado-Saucedo; E. Salas-González; G.M. Zúñiga-González; A. Alonzo-Rojo; I. Gutiérrez-Hurtado; M.P. Gallegos-Arreola
08/08/2011
Case-control study; Interleukin-6; Knee osteoarthritis; Single nucleotide polymorphism; Thai population

Osteoarthritis is a chronic progressive degenerative joint disease characterized by age-related regressive change in articular cartilage. A single nucleotide polymorphism has been described at position -174 of the interleukin-6 (IL-6) promoter region, leading to three possible genotypes, GG, GC, and CC. We investigated a possible association of the IL-6 -174G/C gene polymorphism with ... more

S. Honsawek; B. Deepaisarnsakul; A. Tanavalee; P. Yuktanandana; P. Bumrungpanichthaworn; S. Malila; N. Saetan
12/12/2014
Acanthopanax senticosus; Inflammation; Interleukin-6; Nuclear factor-kB; Tumor necrosis factor-α

The dried roots of the plant Acanthopanax senticosus (AS) are used in traditional Oriental medicine and reportedly possess anti-inflammatory properties in vitro. However, whether AS has the same anti-inflammatory effect in vivo and the underlying mechanisms of this action remain unknown. In this study, we pretreated a mouse model of lipopolysaccharide-induced ... more

X.J. Fei; L.L. Zhu; L.M. Xia; W.B. Peng; Q. Wang
09/26/2014
Case-control study; Chinese population; Coronary artery disease; Interleukin-6

We investigated the relationships between single nucleotide polymorphisms (SNPs) of the interleukin (IL)-6 gene 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) and coronary artery disease (CAD) risk in a Chinese population. This case-control study recruited 296 CAD patients and 327 controls between January 2009 and May 2012. Genotyping of IL-6 174 G>C ... more

G.Q. Sun; G.D. Wu; Y. Meng; B. Du; Y.B. Li
09/26/2014
Genetic polymorphism; Interleukin-10; Interleukin-6; Pulmonary tuberculosis

We investigated the association between interleukin (IL)-6 and IL-10 gene polymorphisms and the susceptibility to pulmonary tuberculosis (PTB). DNA samples were obtained from 191 Han Chinese patients with PTB and 191 healthy control subjects. IL-6 (-572, -174, -597) and IL-10 (-1082, -819) polymorphisms were analyzed using polymerase chain reaction-restriction fragment ... more

F.M. Feng; X.X. Liu; Y.H. Sun; P. Zhang; S.F. Sun; B. Zhang; X.T. Wang; L.J. Lu
06/09/2014
Acute coronary syndrome; Correlation; High-sensitivity C-reactive protein; Interleukin-6

Serum high-sensitivity C-reactive protein (hs-CRP) is a sensitive indicator of inflammation, which is closely related with the progress of plaque formation. Interleukin-6 (IL-6) is one of the inflammatory markers of local coronary plaque and the peripheral blood cycle, promoting the occurrence of atherosclerosis development and plaque rupture. In this study, the correlation of hs-CRP and ... more

X.H. Wang; S.Q. Liu; Y.L. Wang; Y. Jin
05/11/2015
Analgesia; Inflammatory response; Interleukin-10; Interleukin-6

This study aimed to discuss the effects of 3 different analgesia methods on serum IL-6 and IL-10 in patients after cesarean delivery. Thirty full-term women, who underwent cesarean delivery, were randomly assigned to 3 analgesia groups (10 cases each) as follows: intramuscular injection of 100 mg pethidine (NC group), patient controlled epidural analgesia (PCEA) of 5 mg morphine plus 150 ... more

Z.M. Xing; Z.Q. Zhang; W.S. Zhang; Y.F. Liu
04/30/2015
Acute lung injury; High mobility group box 1; Interleukin-6; Tumor necrosis factor α; Ulinastatin

The aim of this study was to investigate the influence of ulinastatin (UTI) on high mobility group box 1 (HMGB1), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 expression in acute lung injury (ALI) rats with sepsis caused by cecal ligation and puncture (CLP) surgery, as well as to examine the underlying biological mechanism. Thirty rats were randomly and evenly divided into sham ... more

S.Y. Wang; Z.J. Li; X. Wang; W.F. Li; Z.F. Lin

Pages