Research Article

Related GMR Articles

10/10/2013
Alkaline phosphatase; ELISA; Helicoverpa armigera Hub.; pET-32a expression vector; Polyclonal antibody

Alkaline phosphatase (ALP) of Helicoverpa armigera Hub. (Lepidoptera; Noctuidae) (GenBank accession No. EU729322) was cloned and expressed. The target gene H.a-ALP, having an open reading frame of 1608 bp, was reverse-transcribed from cDNA by the polymerase chain reaction. The open reading frame of the target gene was cloned into the pET-32a expression vector to obtain ... more

R.A. Khan; M. Rashid; D. Wang; Y.L. Zhang
09/18/2002
Brazil; Glutathione S-transferase; Polymorphism

The glutathione S-transferase (GST) family of enzymes has a vital role in phase II of biotransformation of environmental carcinogens, pollutants, drugs and other xenobiotics. GSTs are polymorphic, with the type and frequency of polymorphism being ethnic dependent. Polymorphisms in GST genes have been shown to be associated with susceptibility to disease and disease outcome. We ... more

A. Rossini; D.C.M. Rapozo; L.M.F. Amorim; J.M.B. Macedo; R. Medina; J.F.N. Neto; C.V.M. Gallo; L.F.R. Pinto
12/09/2011
Glutathione S-transferase; Multiplex PCR; Polymorphism; Type-2 diabetes mellitus

Glutathione S-transferase (GST) protects cells against oxidative stress. We evaluated the effect of genetic polymorphisms of the GST gene family on the risk of developing type-2 diabetes mellitus and on glycemic control. We also investigated the effects of smoking combined with these polymorphisms on type-2 diabetes mellitus risk. We enrolled 100 type-2 diabetes mellitus patients and 100 ... more

M.A. Amer; M.H. Ghattas; D.M. Abo-ElMatty; S.H. Abou-El-Ela
05/11/2010
Chronic obstructive pulmonary disease; Genetic polymorphism; Glutathione S-transferase

Chronic obstructive pulmonary disease (COPD) is a multifactorial disease with possible genetic predisposition and involvement of various environmental factors. Several candidate genes have been reported as potentially associated with this lung disease. The glutathione S-transferase P1 gene (GSTP1) was proposed to be involved in susceptibility to develop COPD. It belongs to the ... more

R. Lakhdar; S. Denden; J. Knani; N. Leban; H. Daimi; M. Hassine; G. Lefranc; J. Ben Chibani; H. Khelil
12/21/2012
Camelina sativa; CMGSTF12; Glutathione S-transferase; TT19

Recently, we found that the Arabidopsis TT19 protein, a glutathione S-transferase, has two functional domains that influence both anthocyanin and proanthocyanidin accumulation. To further understand the function of this protein in the other species, we cloned a cDNA encoding a glutathione S-transferase (namely CMGSTF12) from Camelina sativa, an ... more

Y. Wang; Y. Tang; M. Zhang; F. Cai; J. Qin; Q. Wang; C. Liu; G. Wang; L. Xu; L. Yang; J. Li; Z. Wang; X. Li
10/31/2014
Glaucoma; Glutathione S-transferase; GSTM1; GSTT1

In this study, we evaluated the genotype profile of GSTM1 and GSTT1 polymorphisms in patient carriers of primary open-angle glaucoma in the population of Goiânia, GO, Brazil. This case-control study included 100 Brazilian patients with glaucoma and 53 patients without glaucoma. Blood samples were genotyped for polymorphisms in GST genes using polymerase chain reaction-based ... more

C.T.X. Silva; N.B. Costa; K.S.F. Silva; R.E. Silva; K.K.V.O. Moura
05/09/2014
Acute myeloid leukemia; Glutathione S-transferase; Polymorphisms

We aimed to investigate the relationships between polymorphisms of the glutathione S-transferases (GSTs) GSTM1, GSTTI, and GSTP1 and the risk of developing acute myeloid leukemia (AML). A total of 206 AML cases and 231 controls were collected for our study. The genotyping of GSTs (GSTM1, GSTTI, and GSTP1) was based upon the duplex ... more

Y.M. Zi; S. Wu; D. Ma; C. Yang; M. Yang; Y. Huang; S.J. Yang
12/14/2015
Genetic polymorphisms; Glutathione S-transferase; SA; Turabah

Glutathione-S-transferases (GST) are key phase II detoxifying enzymes that play critical roles in protection against products of oxidative stress and against electrophiles. Glutathione S-transferase mu (GST-M1) and theta (GST-T1) are isoforms of glutathione transferase enzymes that participate in the metabolism of a wide range of chemicals. Deletion variants ... more

A.A. Mansour; O.M. Saleh; T. Askar; A.M. Salim; A. Mergani
04/07/2016
Cardiovascular disease; Glutathione S-transferase; Malaysia; Type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) is believed to be associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress, and have been associated with cardiovascular disease (CVD). The present study assessed the effect of GST polymorphisms on the ... more

A. Etemad; R. Vasudevan; A.F.A. Aziz; A.K.M. Yusof; S. Khazaei; N. Fawzi; S. Jamalpour; M. Arkani; N.A. Mohammad; P. Ismail; A. Etemad; R. Vasudevan; A.F.A. Aziz; A.K.M. Yusof; S. Khazaei; N. Fawzi; S. Jamalpour; M. Arkani; N.A. Mohammad; P. Ismail; A. Etemad; R. Vasudevan; A.F.A. Aziz; A.K.M. Yusof; S. Khazaei; N. Fawzi; S. Jamalpour; M. Arkani; N.A. Mohammad; P. Ismail
04/30/2021
Brazilian population; Chronic lymphocytic leukemia; Genetic polymorphisms; Glutathione S-transferase

Genetic polymorphisms involved in carcinogen metabolism contribute to leukemogenesis risk. Epidemiological studies have revealed genetic alterations in chronic lymphocytic leukemia (CLL), including chromosome alterations, noncoding RNA alterations, and genetic polymorphisms. The bioactivation and detoxification of chemical agents is mediated by xenobiotic ... more

A.Ada S. Reis; K.C. de Alcântara; L.C.A. de Souza; H.G.C. Fontinele; D.L.C. de Farias; L.R.Bdos Anjos; daS. Santos

Pages