Research Article

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05/25/2015
Cancer; Cytosolic serine hydroxymethyltransferase C1420T; Meta-analysis; Single nucleotide polymorphism

Published data regarding the association between the cytosolic serine hydroxymethyltransferase (SHMT1) C1420T (Leu474Phe) polymorphism and solid tumor risk have shown inconclusive results. To derive a more precise estimation of the relationship, we performed a meta-analysis of 23 published studies that included 14,409 cancer cases and 16,996 controls. A comprehensive search was ... more

T.T. Zhao; L.L. Shen; X.L. Zhang; D.Y. Gu; Q. Zhang; X.Y. Huo; C.J. Tang; J.F. Chen
05/25/2015
Follicle-stimulating hormone receptor; Idiopathic infertility; Male infertility; Meta-analysis; Single nucleotide polymorphisms

Male infertility is a complex multifactorial and polygenic disease, and genetic factors play an important role in its formation and development. Recently, the association between follicle stimulating hormone receptor (FSHR) gene polymorphisms and male infertility risk has attracted widespread attention due to the unique biological functions of FSH. The aim of this study was to ... more

X.Q. Wu; S.M. Xu; Y.Q. Wang; Q. Li; Z.Q. Wang; C.L. Zhang; Y. Shen
04/17/2015
Cancer; DNA (cytosine-5)-methyltransferase 3A; Meta-analysis; Single nucleotide polymorphism

Cancer is a major public health problem worldwide that involves complex processes and factors. For instance, methylation is important in tumorigenesis. DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of various studies ... more

C.H. Liu; T. Tao; L. Jiang; B. Xu; L. Zhang; K. Lu; X.W. Zhang; S.Q. Chen; D.C. Liu; M. Chen
03/30/2015
Genetic polymorphism; Meta-analysis; Overactive bladder risk; β3-adrenoceptor genes

Genetic variations in the human β3-adrenoceptor (β3-AR) gene are known to be involved in insufficient relaxation of the bladder muscle during urine storage. The Trp64Arg polymorphism in the β3-AR gene has been found to be an important regulator of the development of overactive bladder (OAB). However, the association between this polymorphism and OAB remains controversial. Therefore, we ... more

H.C. Qu; W. Zhang; Y.L. Liu; P. Wang
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Ischemic stroke; Meta-analysis; β-fibrinogen

To clarify the relationship between the β-fibrinogen (FGB) genetic polymorphism (-148C>T) and ischemic stroke, we identified studies by searching PubMed, EMBASE, and the Chinese National Knowledge Infrastructure (CKNI) databases. Data from eligible studies were extracted and subjected to meta-analysis. Publication bias was tested using a funnel plot. We identified 12 ... more

X.F. Zhang; T.Y. Luo
03/06/2015
AR gene; CAG repeat polymorphism; Isolated hypospadias; Meta-analysis

Studies investigating the association between the CAG repeat polymorphism and the risk of isolated hypospadias have reported conflicting results. The aim of this study was to quantitatively summarize the evidence for such a relationship. Two investigators independently searched the Medline, Embase, CNKI, and Wanfang databases. Weighted mean difference and 95% confidence intervals for the ... more

G. Huang; W. Shan; L. Zeng; L. Huang
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Estrogen receptor alpha; Fracture; Gene polymorphism; Meta-analysis

Numerous studies have evaluated the association between estrogen receptor alpha (ESR1) gene PvuII polymorphism and fracture risk in postmenopausal women. However, the results have been inconsistent. We performed a meta-analysis to examine the association between the ESR1 gene PvuII polymorphism and fracture risk in postmenopausal women. Studies ... more

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02/13/2015
B7-H1 expression; Bladder cancer; Meta-analysis

B7 homolog 1 (B7-H1), which is also known as programmed death-L1, is an important member of the B7/CD28 costimulatory factor superfamily, which are emerging as important mediators of various host immune responses. B7-H1 is differentially expressed in various cell subsets and to different extents in human and murine cells. Human B7-H1 is constitutively expressed at low levels in dendritic ... more

Y.U. Wang; A.N.G. Liu; S.H.A.N. Zhao
02/06/2015
CYP1A1; Gene polymorphism; Hepatocellular carcinoma; Meta-analysis

Numerous studies have evaluated the association between CYP1A1 gene polymorphisms and hepatocellular carcinoma (HCC) risk. However, the specific association is still controversial. The aim of our study was to clarify the effects of CYP1A1 gene polymorphisms (3801 T>C and A2455G) on HCC risk by conducting a meta-analysis. We conducted searches of the literature published in PubMed and ... more

B.W. Yu; L.Q. Zhang; X.L. Teng; Y. Zhang; L.B. Zou; H.Y. Ying
02/03/2015
Comparative mapping; Genetic map; Integrated linkage map; Maize; Meta-analysis; QTL for disease resistance

We collected data regarding 340 disease resistance quantitative trait loci (QTLs) from the maize genomic database (MaizeGDB). We constructed an integrated linkage map and analyzed this map by using the BioMercator 2.1 software with IBM2 2008 Neighbors genetic linkage map as a reference. We used a meta-analysis method to identify five “consensus” synthetic resistance QTLs located on maize ... more

L. Zhao; H.J. Liu; C.X. Zhang; Q.Y. Wang; X.H. Li

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